**Author details**

Kazushi Inoue1,2,3\*, Elizabeth Fry1,2, Dejan Maglic1,2,3 and Sinan Zhu1,3

\*Address all correspondence to: kinoue2@triad.rr.com

\*Address all correspondence to: drkazu12000@yahoo.com

1 The Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, USA

[10] Travis WD. Pathology of lung cancer. *Clin Chest Med* 2002;23,65-81.

lung cancer: Clinical implications. *Thorax* 2003;58:892-900.

genesis of lung cancer. *J Thorac Oncol* 2007;2:327-43.

nary AdCAs in transgenic mice. *Cancer Res* 1992;52:5342-52.

cer. *Ann Rev Physiol* 2002;64,681-708.

*Opin Investig Drugs* 2000;9:565-79.

say. *Adv Cancer Res* 1975;21:1-58.

mice. *Oncogene* 1994;9:2805-15.

1997;16:713-23.

2001;84:813-8.

2005;19:643-64.

[11] Zochbauer-Muller S, Gazdar AF, and Minna JD. Molecular pathogenesis of lung can‐

Genetically Engineered Mouse Models for Human Lung Cancer

http://dx.doi.org/10.5772/53721

51

[12] Fong KM, Sekido Y, Gazdar AF, and Minna JD. Lung cancer. 9: Molecular biology of

[13] Meuwissen R and Berns A. Mouse models for human lung cancer. *Genes Dev*

[14] Worden FP, Kalemkerian GP. Therapeutic advances in small cell lung cancer. *Expert*

[15] Wakamatsu N, Devereux TR, Hong HH, *et al*. Overview of the molecular carcinogen‐ esis of mouse lung tumor models of human lung cancer. *Toxicol Pathol* 2007;35:75-80.

[16] Shimkin MB, Stoner GD. Lung tumors in mice: application to carcinogenesis bioas‐

[17] Pfeifer GP, Denissenko MF, Olivier M, *et al*. Tobacco smoke carcinogens, DNA dam‐ age and p53 mutations in smoking-associated cancers. *Oncogene* 2002;21:7435-51. [18] Sato M, Shames DS, Gazdar AF, *et al*. A translational view of the molecular patho‐

[19] Malkinson AM. Primary lung tumors in mice as an aid for understanding, prevent‐

[20] DeMayo FJ, Finegold MJ, Hansen TN, *et al*. Expression of SV40 T antigen under con‐ trol of rabbit uteroglobin promoter in transgenic mice. *Am J Physiol* 1991;261:L70-6. [21] Sandmoller A, Halter R, Gomez-La-Hoz E, *et al*. The uteroglobin promoter targets ex‐ pression of the SV40 T antigen to a variety of secretory epithelial cells in transgenic

[22] Wikenheiser KA, Clark JC, Linnoila RI, *et al*. Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmo‐

[23] Wikenheiser KA, Whitsett JA. Tumor progression and cellular differentiation of pul‐ monary AdCAs in SV40 large T antigen transgenic mice. *Am J Respir Cell Mol Biol*

[24] Geick A, Redecker P, Ehrhardt A, *et al.* Uteroglobin promoter-targeted c-MYC ex‐ pression in transgenic mice cause hyperplasia of Clara cells and malignant transfor‐ mation of T-lymphoblasts and tubular epithelial cells. *Transgenic Res* 2001;10:501-11.

[25] Ehrhardt A, Bartels T, Geick A, Klocke R, Paul D, Halter R. Development of pulmo‐ nary bronchiolo-alveolar AdCAs in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes. *Br J Cancer*

ing, and treating human AdCA of the lung*. Lung Cancer* 2001;32:265-79.

2 The Department of Cancer Biology, Wake Forest University Health Sciences, Medical Cen‐ ter Boulevard, Winston-Salem, NC, USA

3 Graduate Program in Molecular Medicine, Wake Forest University Health Sciences, Medi‐ cal Center Boulevard, Winston-Salem, NC, USA
