**13. Sunitinib**

Sunitinib is an oral TKI of VEGFR-1, -2, -3, PDGFR-α/β, c-kit, Flt-3 and RET.

It has been studied in advanced NSCLC in two phase II trials. In the first one, 63 pretreated patients received sunitinib as single agent, achieving an ORR of 11.1% (95%CI: 4.6–21.6), me‐ dian PFS of 12 weeks (95%CI: 10.0-16.1) and median OS of 23.4 weeks (95%CI: 17.0-28.3) [93]. In the other phase II trial, 47 pretreated patients received sunitinib on a continuousdosing schedule (37.5 mg/day). The ORR was only 2.1%, but median PFS and OS were 11.9 weeks (95%CI: 8.6-14.1) and 37.1 weeks (95%CI: 31.1-69.7), respectively [94].

There are ongoing studies investigating sunitinib in patients with NSCLC, including the phase II CALGB 30704 trial evaluating sunitinib as second-line therapy and the phase III CALGB 30607 study of sunitinib as maintenance therapy.
