**8.2. Aflibercept**

Aflibercept (VEGF-Trap) is a recombining fusion protein, which is added to VEGFR-1, VEGFR-2 and to the placental growth factor (PlGF).

In a phase II trial in patients with lung adenocarcinoma treated after several treatment lines, aflibercept in a dose of 4 mg/kg was administered intravenously every 14 days, reaching a RR of 2%, with a PFS of 2.7 months and an OS of 6.2 months [78]. A phase III trial in second line after failure to cisplatin-based chemotherapy compared aflibercept vs docetaxel (VITAL trial). This trial showed an improved RR (23.3& vs 8.9%) and PFS (HR: 0.82), but the primary endpoint, OS, was not reached (HR: 1.01).
