Contents

#### **Preface XI**


Chapter 6 **Perioperative Surgical Site Infections and Complications in Elective Orthopedic Surgery in Patients with Rheumatoid Arthritis Treated with Anti-Tumor Necrosis Factor-Alpha Agents − Discontinue or Not, Clinical Dilemma 109** Koichiro Komiya and Nobuki Terada


Michal Gajewski, Slawomir Maslinski, Przemyslaw Rzodkiewicz and Elzbieta Wojtecka-Lukasik

Preface

Silvia Valsa of InTech's for their unfailing help.

First of all, we are delighted to be able to provide the "Innovative Rheumatology" to everyone involved in the treatment and research of rheumatoid arthritis. In recent years, the treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is now possible, and the quality of life of patients with rheumatoid arthritis in long-term has been able to improve by advances in treatment. However, there are still many problems to be overcome before achieving the treatment of rheumatoid arthritis. All of review articles presented on this book are explaining treatment, basic research, and patient care of rheumatoid arthritis with innovative perspective and ideas. I hope that the ideas that have been described in these articles help the reader to resolve the outstanding issues in rheumatoid arthritis. Finally, the editor would like to thank the wonderful authors for their contribution to this book. Furthermore, I would like to thank Mr. Danijela Duric and Ms.

**Hiroaki Matsuno**

Toyama, Japan

Matsuno Clinic for Rheumatic Diseases,

Director,


## Preface

Chapter 7 **Extraskeletal Manifestations in Rheumatoid Arthritis -**

Chapter 8 **Small Molecule DMARD Therapy and Its Position in RA**

Chapter 10 **Laryngeal Manifestations of Rheumatoid Arthritis 215**

Chapter 11 **Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease 247**

Chapter 12 **Efficacy of Nandrolone Decanoate in Treating Rheumatoid**

Francesco Casanova and Peter J. Maddison

Chapter 13 **Role of Cysteine Cathepsins in Joint Inflammation and**

**Animal Models 287**

Uta Schurigt

**Cachexia in Male Rheumatoid Arthritis Patients 271**

Stevan Stojanović and Branislav Belić

Chapter 9 **Gas-Therapy in Rheumatoid Arthritis Treatment: When West Meets East – Actual Medical Concepts with Ancient**

Katarzyna Romanowska-Próchnicka, Przemysław Rzodkiewicz, Marzena Olesińska, Dariusz Szukiewicz and Sławomir Maśliński

Michal Gajewski, Slawomir Maslinski, Przemyslaw Rzodkiewicz and

María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A.

Andrew B. Lemmey, Srinivasa Rao Elamanchi, Samuele M. Marcora,

**Destruction in Human Rheumatoid Arthritis and Associated**

**Clinical Cases 131**

**VI** Contents

**Treatment 165** Hiroaki Matsuno

**World Ideas 189**

Burgos

Elzbieta Wojtecka-Lukasik

First of all, we are delighted to be able to provide the "Innovative Rheumatology" to everyone involved in the treatment and research of rheumatoid arthritis. In recent years, the treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is now possible, and the quality of life of patients with rheumatoid arthritis in long-term has been able to improve by advances in treatment. However, there are still many problems to be overcome before achieving the treatment of rheumatoid arthritis. All of review articles presented on this book are explaining treatment, basic research, and patient care of rheumatoid arthritis with innovative perspective and ideas. I hope that the ideas that have been described in these articles help the reader to resolve the outstanding issues in rheumatoid arthritis. Finally, the editor would like to thank the wonderful authors for their contribution to this book. Furthermore, I would like to thank Mr. Danijela Duric and Ms. Silvia Valsa of InTech's for their unfailing help.

#### **Hiroaki Matsuno**

Director, Matsuno Clinic for Rheumatic Diseases, Toyama, Japan VIII Preface

**Section 1**

**Basic Science**

**Section 1**
