**Meet the editor**

Alvaro G. Estevez, Ph.D. is an Associate Professor of Medicine at the Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida. Dr. Estevez performed his graduate studies at the University of Buenos Aires and was a post-doctoral fellow with Dr. Joseph S. Beckman at the University of Alabama at Birmingham, where he become Assistant Professor in the

Department of Physiology and Biophysics. Dr. Estevez was also a faculty member at the Weill Cornell Medical College, the Burke Medical Research Institute and Oregon State University. Dr. Estevez research focalizes on oxidative mechanisms of motor neurons death in ALS. He published over 60 papers and reviews and his work is founded by the NIH/NINDS.

Contents

**Preface VII**

Chapter 1 **Pathophysiology of Amyotrophic Lateral Sclerosis 1**

Jin Hee Shin and Jae Keun Lee

Camu and Cédric Raoul

**Lateral Sclerosis 141**

Alvaro G. Estévez

**Challenges 159**

Arun Aggarwal

Fabian H. Rossi, Maria Clara Franco and Alvaro G. Estevez

**Phenotype in ALS — A Focus on Italian Population 73**

Melissa Bowerman, Thierry Vincent, Frédérique Scamps, William

María Clara Franco, Cassandra N. Dennys, Fabian H. Rossi and

**Estimation (MUNE) to Assess the Potential Therapeutic Benefits**

Chapter 2 **Multiple Routes of Motor Neuron Degeneration in ALS 35**

Chapter 3 **Genetics of ALS and Correlations Between Genotype and**

L. Diamanti, S. Gagliardi, C. Cereda and M. Ceroni

Chapter 5 **Superoxide Dismutase and Oxidative Stress in Amyotrophic**

Chapter 6 **The Use of Human Samples to Study Familial and Sporadic Amyotrophic Lateral Sclerosis: New Frontiers and**

Laura Ferraiuolo, Kathrin Meyer and Brian Kaspar

Chapter 7 **The Role of the Statistical Method of Motor Unit Number**

**Amyotrophic Lateral Sclerosis 183**

**of Riluzole on Patients with Pre-symptomatic Familial**

Chapter 4 **The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis 97**
