**1. Introduction**

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Multiple myeloma (MM) or plasma cell myeloma is a neoplastic proliferation of plasma cells that primarily involves the bone marrow but may originate from extramedullary sites [1-4]. Although it is uncommon in veterinary medicine, it has been reported in several species, in‐ cluding cats, dogs and, horses [1,3,5-10]. The frequency of MM in cats is slightly <1% of all malignant neoplasms. Canine MMs account for only 0.3% of all malignancies in dogs. MMs account approximately 2% of all hematopoietic neoplasms in both dogs and cats [4]. Most of the reports in the literature are limited to 1 to 16 case studies [4,11-16]. However, in a recent report regarding the incidence of bone disorders diagnosed in dogs, MM was the second most frequently diagnosed neoplastic condition in canine bone marrow [17].

Similarly, MM is an extremely rare disorder in horses. Ten cases, nine from the literature and a new case, were described by Edwards et al. [1] and only six additional cases have been described lastly [3,6-8,18]. Because of the uncommonly diagnosis of equine MM, the prevalence of this neoplasm is unknown in the horse.
