Contents

#### **Preface XV**




Chapter 8 **Adipose Derived Stem Cells: Current State of the Art and Prospective Role in Regenerative Medicine and Tissue Engineering 179**

Vincenzo Vindigni, Giorgio Giatsidis, Francesco Reho , Erica Dalla Venezia , Marco Mammana and Bassetto Franco


Chapter 14 **Skeletal Muscle Ventricles (SMVs) and Biomechanical Hearts (BMHs) with a Self-Endothelializing Titanized Blood Contacting Surface 341** Norbert W. Guldner, Peter Klapproth, Hangörg Zimmermann and Hans- H. Sievers

Chapter 15 **Cartilage Tissue Engineering: The Role of Extracellular Matrix (ECM) and Novel Strategies 365**

> Zaira Y. García-Carvajal, David Garciadiego-Cázares, Carmen Parra-Cid, Rocío Aguilar-Gaytán, Cristina Velasquillo , Clemente Ibarra and Javier S. Castro Carmona

	- **Section 3 Regeneration of Tissues and Organs 409**

Chapter 7 **Is the Articular Cartilage Regeneration Approachable Through**

**Prospective Role in Regenerative Medicine and Tissue**

José M. López-Puerta, Plácido Zamora-Navas, Silvia Claros, Gustavo A. Rico-Llanos, Inés Avedillo, José A. Andrades and José Becerra

Vincenzo Vindigni, Giorgio Giatsidis, Francesco Reho , Erica Dalla

Tran Le Bao Ha, To Minh Quan, Doan Nguyen Vu and Do Minh Si

M. Arnal-Pastor, J. C. Chachques, M. Monleón Pradas and A. Vallés-

Dragica Smrke, Primož Rožman, Matjaž Veselko and Borut Gubina

Norbert W. Guldner, Peter Klapproth, Hangörg Zimmermann and

**Mesenchymal Stem Cells Therapies? 155**

Chapter 8 **Adipose Derived Stem Cells: Current State of the Art and**

Venezia , Marco Mammana and Bassetto Franco

Chapter 9 **Regulatory Issues in the Therapeutic Use of Stem Cells 203** Bridget M. Deasy, Jordan E. Anderson and Shannon Zelina

Chapter 10 **The Evolution of Three-Dimensional Cell Cultures Towards Unimpeded Regenerative Medicine and Tissue**

Aleksandar Evangelatov and Roumen Pankov

Chapter 11 **Naturally Derived Biomaterials: Preparation and**

Chapter 12 **Biomaterials for Cardiac Tissue Engineering 275**

**Autologous Bone Technique 325**

**Contacting Surface 341**

Hans- H. Sievers

Chapter 13 **Treatment of Bone Defects — Allogenic Platelet Gel and**

Chapter 14 **Skeletal Muscle Ventricles (SMVs) and Biomechanical Hearts (BMHs) with a Self-Endothelializing Titanized Blood**

**Engineering 179**

**VI** Contents

**Section 2 Scaffolds and Matrices 219**

**Engineering 221**

**Application 247**

Lluch

	- **Section 4 Clinical Perspective of Tissue Engineering and Cell-Based Therapies 743**

Chapter 32 **Autologous Muscular Treatment Options for Endstage Heart Failure — A Critical Appraisal of the Dynamic Cardiomyoplasty (DCMP) vs. a New Concept of a Closed-Loop Controlled DCMP (CLC-DCMP) 795** Norbert W. Guldner, Peter Klapproth and Hans-H. Sievers

Chapter 24 **Advances in Bone Tissue Engineering 599**

**Biomaterials 615**

**VIII** Contents

Mahesh Choolani and Jerry K.Y. Chan

Almagro and José A. Moreno-Moreno

**Regeneration in Dentistry 713**

**of Electrical Stimulation 745**

**Therapies 743**

Masahiro Kameda

**Melanocytes 759**

Chapter 25 **Bone Engineering: A Matter of Cells, Growth Factors and**

Chapter 26 **Adaptation and Evolution in a Gravitational Environment — A**

Chapter 27 **Skeletal Muscle Regeneration for Clinical Application 679** Fahd Azzabi Zouraq, Meline Stölting and Daniel Eberli

Gardin, Eriberto Bressan and Barbara Zavan

**Section 4 Clinical Perspective of Tissue Engineering and Cell-Based**

Chapter 30 **Pigmented Skin Models: Understand the Mechanisms of**

Chapter 31 **Cell Therapy and Muscle Regeneration: Skeletal Myogenic**

Yingai Shi, YuLin Li, JinYu Liu and Yuanyuan Zhang

**Treatment of Urinary Incontinence 787**

Chapter 29 **Regenerative Medicine for Neurological Diseases with the Use**

Chapter 28 **Delivery Systems and Role of Growth Factors for Alveolar Bone**

Stefano Sivolella, Marleen De Biagi, Giulia Brunello, Sara Ricci, Drazen Tadic, Christiane Marinc, Diego Lops, Letizia Ferroni, Chiara

Isabelle Gendreau, Laetitia Angers, Jessica Jean and Roxane Pouliot

**Differentiation of Urine-Derived Stem Cells for Potential Use in**

Chao Le Meng Bao, Erin Y. Teo, Mark S.K. Chong, Yuchun Liu,

José A. Andrades, Lucía Narváez-Ledesma, Luna Cerón-Torres, Anyith P. Cruz-Amaya, Daniel López-Guillén, M. Laura Mesa-

**Theoretical Framework for the Limited Re-Generative Post-Natal Time Window of the Heart in Higher Vertebrates 643** Michele Mario Ciulla, Gianluca Lorenzo Perrucci and Fabio Magrini Chapter 33 **Complications of Post-Transplant Immunosuppression 831** Raffaele Girlanda
