Contents

#### **Preface XI**


Chapter 8 **The Insulin-Like Growth Factor System in the Human Pathology 197**

Emrah Yerlikaya and Fulya Akin

Chapter 9 **Pediatric Nonalcoholic Fatty Liver Disease 221** Ebe D'Adamo, M. Loredana Marcovecchio, Tommaso de Giorgis, Valentina Chiavaroli, Cosimo Giannini, Francesco Chiarelli and Angelika Mohn

Preface

liver disease.

pathologies related to the endocrine field.

The endocrine system plays a vital role in whether or not you develop a wide range of dis‐

This book includes selected contemporary topics representing exciting recent developments in the field of endocrine and endocrine-related diseases. It is the result of a collaboration among eminent scientists and clinicians coming from eight different countries, including Ar‐

Basic and advanced recent trends and research studies in a number of endocrine and endo‐ crine-related disorders are covered by the different chapters of the book. We will read about hereditary neuroendocrine tumors, with emphasis on their still poorly defined natural histo‐ ry and clinical course; pituitary tumors, with a comprehensive overview of the recent ad‐ vances in their pathogenesis; thyroid dysfunctions, including those related to aging and iodine deficiency; diabetes, with its hepatic complications, and double diabetes, a new defi‐ nition that summarizes the coexistence of features of both type 1 and type 2 diabetes in the same individual, with a comprehensive discussion of the various aspects of this disorder and a focus on the search for a treatment paradigm in children and adolescents. Moreover, we will read about the testosterone as a new player in metabolic disorders and as a potential drug to counteract skeletal muscle diseases; the glucagon-like peptide type 1 and its multi‐ ple actions for which it can be considered an anti-diabetogenic agent and may have impor‐ tant implications in pathophysiological states such as obesity; the-insulin-like-growth-factor role in different human pathologies, including cancer; and the pediatric nonalcoholic fatty

I hope that, at the end, the reader will have a critic and advanced overview of selected hot

**Dr. Monica Fedele**

Naples, Italy

National Research Council,

Institute of Experimental Endocrinology and Oncology,

eases, not only including strictly endocrine-diseases.

gentina, Brazil, Chile, Italy, Romania, Spain, Turkey and United States.

Chapter 10 **Anabolic/Androgenic Steroids in Skeletal Muscle and Cardiovascular Diseases 237** Carla Basualto-Alarcón, Rodrigo Maass, Enrique Jaimovich and Manuel Estrada
