**6. Non-oncological and off-label pdt applications in dermatology**

PDT is already approved for the treatment of actinic keratosis and basal cell carcinoma. Offlabel uses for PDT have been indicated for several dermatological conditions such as photodamaged skin, scleroderma, warts, cutaneous leishmaniosis, psoriasis, cutaneous T-cell lymphoma and acne [20, 47]. Infectious disease has the potential to become one of the main indications of PDT in Dermatology. The microbiological control of bacteria, fungi and protozoa ininfectedlesionshasbeenpresented[48-51].Onychomicosisisoneofthenewindications,where PDT presents good results even in cases where the antifungal systemic therapy failured (Paulada-Silva, A. et al., Fast elimination of onychomycosis by hematoporphyrin derivative-photody‐ namic therapy. Accepted by Photodiagnosis and Photodynamic Therapy on December2012).
