**Author details**

Bourlaye Fofana1\*, Kaushik Ghose1,2, Bob Chapman1 and Kevin Sanderson1

1 Crops and Livestock Research Centre, Agriculture and Agri-Food Canada, Charlottetown, PEI, Canada

2 University of Prince Edwards Island and National Research Council, Charlottetown, PEI, Canada

#### **References**


[17] Joly S, Starr JR, Lewis WH, Bruneau A. Polyploid and hybrid evolution in roses east of the Rocky Mountains. American Journal of Botany 2006;93:412-425.

**References**

2005;102:18315-18320.

Domestic Donkey. Science 2004;304:1781.

domestication. Ann Bot 2007;100:893-901.

kushitsu Kakusan Koso 2007;52:1942-1946.

American Journal of Botany 1999;86:522.

Willey Blackwell; 2010. p. 199-255.

World. Nature 1977;268:591-595.

flanze 1981;29:177-198.

2004;24:1-44.

Botany 2007;32.

molecular genetics. Ann Bot 2007;100:925-940.

56 Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

[1] Erickson DL, Smith BD, Clarke AC, Sandweiss DH, Tuross N. An Asian origin for a 10,000-year-old domesticated plant in the Americas. Proc Natl Acad Sci USA

[2] Beja-Pereira A, England PR, Ferrand N, ordan S, Bakhiet AO, Mohammed A. Abdalla MA, Marjan Mashkour M, Jordana J, Taberlet P, LuikartG. African Origins of the

[3] Pickersgill B. Domestication of plants in the Americas: insights from Mendelian and

[4] Pigershill B. Taxonomy and the origin and evolution of cultivated plants in the New

[5] Vaughan DA, Balazs E, Heslop-Harrison JS. From Crop Domestication to Super-

[7] Van Raamsdonk LWD. The cytological and genetical mechanisms of plant domestica‐

[8] de Wet JMJ. Species concepts and systematics of domesticated cereals. Die Kutturp‐

[9] Yamasaki M. Maize domestication and breeding based on genomic variation. Tanpa‐

[10] Yamasaki M, Wright SI, McMullen MD. Genomic screening for artificial selection during domestication and improvement in maize. Ann Bot 2007;100:967-973.

[11] Casas A, Caballero J, Valiente-Banuet A, Soriano JA, Davila P. Morphological variation and the process of domestication of *Stenocereus stellatus* (*Cactaceae*) in Central Mexico.

[12] Gepts P. Crop domestication as a long-term selection experiment. Plant Breeding

[13] Werlemark G, Nybom H. Dogroses: Botany, Horticulture, genetics, and Breeding.

[14] Office of the gene technology regulator. The biology and Ecology of *Rosa x hybrida*

[16] Bruneau A, Starr JR, Joly S. Phylogenetic relationships in the genus *Rosa*: new evidence from chloroplast DNA sequences and an appraisal of current knowledge. Systematic

(Rose). In: D. o. H. a. a. Australlian Government editor; 2005. p. 19. [15] Linnaeus C. editor. Species plantarum. Laurentus salvius; 1753. p. 1200.

[6] Simmonds NW. Principles of crop improvement. N.Y.: Longman; 1979. p. 408.

tion exemplified by four crop models. Botanical review 1995;61:367-399.


[46] Werlemark G, Nybom H. Skewed distribution of morphological character scores and molecular markers in three interspecific crosses in *Rosa* section Caninae. Hereditas (Lund) 2001;134:1-13.

[33] Raymond O, Fiasson JL, Jay M. Synthetic taxonomy of *Rosa* races using ACT-STATIS.

[34] Uggla M, Gao X, Werlemark G. Variation among and within dogrose taxa (*Rosa* sect. caninae) in fruit weight, percentages of fruit flesh and dry matter, and vitamin C content. Acta agriculturae Scandinavica Section B, Soil and plant science

[35] Ma Y, Crane CF, Byrne DH. Karyotypic relationships among some *Rosa* species.

[36] Mullis K, Faloona F, Sharf S, Saiki R, Horn G, Erlich H. Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction. Cold Spring Harb Symp Quant Biol

[37] Wu S, Ueda Y, He H, Nishihara S, Matsumoto S. Phylogenetic analysis of Japanese *Rosa*

[38] Wu S, Ueda Y, Nishihara S, Matsumoto S. Phylogenetic analysis of Japanese *Rosa* species using DNA sequences of nuclear ribosomal internal transcribed spacers (ITS).

[39] Joly S, Bruneau A. Incorporating allelic variation for reconstructing the evolutionary history of organisms from multiple genes: An example from *Rosa* in North America.

[40] Joly S, Bruneau A. Measuring branch support in species trees obtained by gene tree

[41] Kimura T, Nishitani C, Iketani H, Ban Y, Yamamoto T. Development of microsatellite

[42] Nybom H, Esselink GD, Werlemark G, Vosman B. Microsatellite DNA marker inheri‐ tance indicates preferential pairing between two highly homologous genomes in polyploid and hemisexual dog-roses, *Rosa* L. sect. Caninae DC. Heredity

[43] Rusanov K, Kovacheva N, Vosman B, Zhang L, Rajapakse S, Atanassov A, Atanassov I. Microsatellite analysis of *Rosa damascena* Mill. accessions reveals genetic similarity between genotypes used for rose oil production and old Damask rose varieties. Theor

[44] Joly S, Bruneau A. Delimiting species boundaries in *Rosa* Sect. Cinnamomeae (*Rosa‐*

[45] Werlemark G, Uggla M, Nybom H. Morphological and RAPD markers show a highly skewed distribution in a pair of reciprocal crosses between hemisexual dog rose

species, *Rosa* sect. Caninae. Theoretical and Applied Genetics 1999;98:557-563.

species using matK sequences. Breeding Science 2000;50:275-281.

Journal of Horticultural Science and Biotechnology 2001;76:127-132.

markers in rose. Molecular Ecology Notes 2006;6:810-812.

*ceae*) in Eastern North America. Syst Bot 2007;32:819-836.

Zeitschrift fur Naturforschung Section C, Biosciences 2000;55:399-409.

58 Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

2003;53:147-155.

1986;51:263-273.

Caryologia 1997;50:317-326.

Syst Biol 2006;55:623-636.

2004;92:139-150.

Appl Genet 2005;111:804-809.

parsimony. Syst Biol 2009;58:100-113.


[76] Hashidoko Y. The phytochemistry of *Rosa rugosa*. Phytochemistry 1996;43:535-549.

[61] Tuba J, Hunter G, Hutchinson MJ, Kennedy LL. On sources of vitamin C. 1. Rose hips.

[62] Grossi C, Raymond O, Jay M. Flavonoid and enzyme polymorphisms and taxonomic organisation of *Rosa* sections: *Carolinae*, *Cinnamomeae*, *Pimpinellifoliae* and *Synstylae*.

[63] Wissemann V. Evolution by hybridisation. The influence of reticulate evolution on biosymmetrical patterns and processes in plants. Theory in Biosciences

[64] Ercişli S, Güleryüz M. A study of the propagation of the hardwood cuttings of some

[65] Ghose K, McCallum B, Kirby C, Sanderson K, Fofana B. Genetic and metabolite diversity in Atlantic Canada wild roses and its implications in drug and cultivar development. Plant Biology 2010 Meeting. Montreal Convention Centre, Montreal, July

[66] Joublan JP, Rios D. Rose culture and industry in Chile. Acta Horticulturae

[67] Nybom H, Werlemark G, Carlson-Nilsson U, Olsson A, Uggla M. Genetic variation in a new crop - dogroses (*Rosa* sect. *Caninae* ) for commercial rosehip production. Acta

[68] Watson S. Contributions to American botany. I. A history and revision of the roses of North America. Proceedings of the American Academy of Arts and Sciences

[69] Crepin F. Rosae Americanae. I. Observations upon the genus *Rosa* in North America.

[70] Crepin F. Sketch of a new classification of roses. Journal of the Royal Horticultural

[71] Erlanson MacFarlane EW. The old problem of sepcies in *Rosa* with special reference to

[72] Erlanson MacFarlane EW. A self-polination mechanism and other Items in Rose

[73] Ghose K, McCallum J, Kirby C, Sanderson K, Fofana B. Genetic and metabolite diversity in Atlantic Canada wild roses and its implications in drug and cultivar development. 2nd Maritime Natural Products Conference. Charlottetown, Aug.31-Sept 2, 2010 PE,

[75] Bayrak A, Akguel A. Volatile oil composition of Turkish rose (*Rosa damascena*). Journal

north America. America Rose Annual 1966;51:150-160.

[74] De pronville m. Monographie du genre Rosier. Paris: Audot; 1824.

of the Science of Food and Agriculture 1994;64:441-448.

species. America Rose Annual 1961;48:188-193.

rose hips. Turkish Journal of Agriculture & Forestry 1999;23:305-310.

Canadian Journal of Research, Section Botanical Sciences 1943;2:363-373.

Biochemical Systematics and Ecology 1998;26:857-871.

60 Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

2005;123:223-233.

31-August 4, 2010; 2010.

Horticulturae 1999;484:139-145.

Botanical Gazette 1896;22:1-34.

Society 1889;11:217-228.

2005;690:65-69.

1885;20:324-352.

Canada; 2010.

