**5. SIH and fever**

The fever seen in SIH cases those mimic meningoencephalitis might be explained by the re‐ lease of pyrogenic cytokines by endothelial cells and astrocytes of blood-brain barrier secon‐ dary to a drop in CSF pressure [10]. These cytokines are the main mediators of inflammatory response in infectious and non-infectious disorders. Another suggested mechanism for fever would be an impaired hypothalamic thermoregulation secondary to mechanical distractions and venous engorgement in cavernous sinus and diencephalic region.
