**6. History of human YF outbreaks**

At the beginning of the 20th century, a large number of yellow fever epidemics were record‐ ed in both African and American cities, and these occurred against a background of annual cases. Table 1 and 2 lists an overview on the historical outbreaks in both tropical Africa and America by year and countries. Yellow fever epidemics are re-emerging in Africa and Amer‐ ica, and the occurrence of repeated rural outbreaks increases the risk for major urban epi‐ demics. The first disease outbreak that can reliably be regarded as YF was documented in 1648 and occurred in the Yucatan, Mexico and Guadeloupe [27].


Yellow Fever Encephalitis: An Emerging and Resurging Global Public Health Threat in a Changing Environment http://dx.doi.org/10.5772/46041 213


**Table 1.** The history of Yellow fever outbreaks in subtropical regions of America
