**11. Elimination of triggering antigens**

The elimination or avoidance of an antigen in a genetically susceptible individual may prevent the onset of disease or reduce disease activity. Cessation of offending medica‐ tions such as penicillamine or captopril results in remission of drug-induced PF [25],[201], [202]. Similarly, patients with endemic pemphigus, who relocate from their native rural endemic environment to a more industrialized area experience clinical and immunologic disease regression [203]. Hence, the clear identification of a triggering environmental antigen such as arthropod protein, microorganism or otherwise, will not only enhance our understanding of disease pathogenesis but also significantly enhance therapies in endem‐ ic pemphigus and possibly non-endemic PF [5].
