**Abbrevations**

ADAM: a disintegrin and metalloprotease domain, APH-1: anterior pharynx defective 1, AICD: APP intracellular domain, APP: amyloid precursor protein, APP CTFs: APP C-termi‐ nal fragments, BACE1: β-site APP cleaving enzyme 1/β-secretase, CDK5: cyclin-dependent kinase-5, CD spectra: Circular dichroism spectra, DRM: detergent-resistant membrane, GSK3:βglycogen synthase kinase-3β, JNK: c-Jun N-terminal kinase, imAPP: immature APP, mAPP: mature APP, pAICD; nAICD; nonphosphorylated AICD, nCTFs; nonphosphorylated CTFs, phosphorylated AICD, pCTFs; phosphorylated CTFs, PS: presenilins, PEN2; preseni‐ lin enhancer 2, PTB/PI domain; phosphotyrosine binding/interaction domain; sAPP; soluble APP, X11L; X11-like.
