**5. AAT use in some chronic diseases**

Since Alzheimer´s disease is generally observed in elderly people, it may be concomitant with some other chronic diseases. Among these diseases, cardiovascular diseases are the leading ones. Conducted studies have indicated that systolic blood pressure and plasma triglyceride levels are lower in pet owner subjects when compared with the non-owners. [38] In Odendaal's study, neurochemicals (β-endorphin, oxytocin, prolactin, phenylacetic acid, dopamine, cortisol) related to drop down of blood pressure were evaluated between 18 subjects and 18 dogs before and after the positive interactions. Statistically significant data (*p*<0.05) have indicated that neurochemicals related to blood pressure are increased in both groups and attention behavior function is increased after AAT except cortisol (cortisol was low signifi‐ cantly in humans, but this decrease was not found to be significantly in dogs. [58] It has been reported in studies of another chronic disease, namely cancer, that AAT had positive effects both on patients and their relatives. [46], [59], [60] The positive effects are reported as decreased stress and anxiety; compliance with treatment and improvement in adaptation; relaxation; better nutrition; physical activity; socialization; participitating in new activities; verbalization of fright and concerns; decreased nervousness; increased feeling of happiness; thus improve‐ ment in life quality. [46], [60]

Similar results have been obtained in studies performed on disabled subjects. [61]- [64] Especially achieved improvements were increased non-verbal interactions, physical activities, and daily life activities leading to increased life quality. Although these studies have been performed commonly in children with widespread developmental disorders, it should also be considered that Alzheimer patients may have various disabilities, which would lower their life quality, so their daily life activities may be limited according to the stage and severity of disease. When evaluated in this aspect, animal assisted therapies will provide significant benefits.

In a study performed on AIDS patients, it has been reported that cat assisted therapy has supported patients' communications with their families and friends, and has provided prevention from the feeling of loneliness.
