**Meet the editor**

Inga Zerr is Professor at the Department of Neurology and Chair of the Clinical Dementia Center at the University Medical School, Göttingen. She received her habilitation (venia legendi for neurology) in 2001 for her work on cerebrospinal fluid in human prion diseases. With over 180 publications, Inga Zerr's current research interests include clinicopathological characterisation of molecular

disease subtypes in neurodegenerative dementia (such as prion diseases, Alzheimer's disease) and the understanding of the molecular basis which leads to the phenotypic diversity in these pathological conditions.

Contents

**Preface IX**

**Health and Disease 3**

Ulrike Müller and Klemens Wild

**and Neurodegeneration 39**

Chapter 4 **γ-Secretase — Regulated Signaling and Alzheimer's Disease 61**

**Tau in Alzheimer's Disease 89**

Ohkawara

**Mechanisms 109**

Chapter 1 **Structure and Function of the APP Intracellular Domain in**

Chapter 2 **Mechanism of Alzheimer Amyloid β-Protein Precursor Localization to Membrane Lipid Rafts 23**

Chapter 3 **The Amyloidogenic Pathway Meets the Reelin Signaling**

Chapter 5 **Phosphorylation of Tau Protein Associated as a Protective**

Chapter 6 **Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple**

Yuhki Saito, Takahide Matsushima and Toshiharu Suzuki

**Cascade: A Cytoskeleton Bridge Between Neurodevelopment**

Daniel A. Bórquez, Ismael Palacios and Christian González-Billault

Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh and Takeshi

**Mechanism in the Presence of Toxic, C-Terminally Truncated**

José Luna-Muñoz, Charles R. Harrington, Claude M. Wischik, Paola Flores-Rodríguez, Jesús Avila, Sergio R. Zamudio, Fidel De la Cruz, Raúl Mena, Marco A. Meraz-Ríos and Benjamin Floran-Garduño

Lucia Pastorino, Asami Kondo, Xiao Zhen Zhou and Kun Ping Lu

**Section 1 Pathogenesis 1**
