**Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular Dementia**

Rita Moretti, Paola Torre, Francesca Esposito, Enrica Barro, Paola Tomietto and Rodolfo M. Antonello

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/54264

**1. Introduction**

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There is currently no consensus on the nosological position of apathy in clinical practice. The clinical significance of negative symptoms such as apathy is increasingly recognized in neurological and psychiatric disorders, particularly those associated with frontal-subcortical dysfunction (Starkstein et al., 2008; Moretti et al., 2012). Apathy is defined as lack of motiva‐ tion as manifested by diminished goal-directed behavior, reduced goal-directed cognition, and decreased emotional engagement, a reduced interest and participation in normal pur‐ poseful behavior, problems in initiation or sustaining an activity, lack of concern or indiffer‐ ence, and a flattening of affect. The prevalence of apathy in neurodegenerative disorders, such as Parkinson's disease vary between 16.5% and 51%, depending upon the instrument for assessment and on the samples examined. Apathy is quite common also in sVAD; differ‐ ent studies try to define its role in AD, but, even the most recent and well-conducted did not distinguish between early and advanced stages of AD, or even between AD and AD with parkinsonism (Starkstein et al., 2008; Stuss et al., 2000; Dujardin et al., 2009). It has been hy‐ pothesized that dysfunction of the nigro-striatal pathway may play an important role in the pathophysiology of apathy in neuro-degenerative disorders. In fact, apathy seems to be in‐ dependent of disease duration, disability and severity of parkinsonism, and levodopa dose in PD, indicating that the brain changes underlying apathy differ from those associated with motor symptoms. Much more interesting is that not all the PD patients become apathetic, indicating that apathy should not entirely be considered a dopamine-dependent syndrome

© 2013 Moretti et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2013 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

in PD, and is in fact present even in not-purely dopaminergic alterations, such as AD or sVAD (Moretti et al., 2012; Levy et al., 1998; Brown and Pluck, 2000). Existing evidence sug‐ gests that apathy can be related to depression, as a key symptom of major depression or side-effect of antidepressant or antipsychotic drugs (Chase et al., 2011). Though, apathy and depression clearly dissociate in specific motor disorders, such as progressive supranuclear palsy, in which there is a high incidence of apathy but a low incidence of depression (Aars‐ land et al., 2001). Other Authors suggested that apathy might be a consequence of chronic disabling disease and its impact on mobility and opportunity for participation in normal ac‐ tivities. Thus, many Authors used the term "premature social aging" to describe the find‐ ings that patients with apathy have little in the way of interests or social activities, spending more time in solitary activities such as watching television or just sitting doing nothing (Starkstein et al., 1992). If apathy is a primary consequence of physical disability or impair‐ ment in daily living, then similar changes might be predicted for patients with articular/ orthopedic impairment. Surprisingly, the osteoarthritis sample population, despite the mo‐ tor disability, showed no evidence of apathy. It is thus likely that the physiopathology of apathy is a multifaceted entity. The aim of this preliminary was to assess the behavior spec‐ trum of Alzheimer's Disease (AD) and that of subcortical Vascular Dementia (sVAD), with a particular concern for apathy, and to assess its possible role in the differential clinical diag‐ nosis, as compared to other behavioral changes and different neuropsychological patterns.

an informed caregiver, unavailability of neuroradiological examination, and/or the assump‐ tion of psychotropic drugs within two months prior to the clinical assessment. Therefore, five patients were excluded in consequence of lack of a sufficiently informed caregiver and twelve subjects were excluded because they assumed psychotropic drugs during the two

Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular

Dementia

361

http://dx.doi.org/10.5772/54264

Study subjects underwent a standardized baseline assessment that included a detailed histo‐ ry, a physical examination, laboratory tests and psychiatric evaluations. The physical exami‐ nation included evaluations of pulse rate and rhythm, blood pressure, heart size and sounds, peripheral pulses, retinal vessel and carotid artery evaluation, electrocardiographic evaluation, and chest X-ray. All patients were followed with periodical neurological and neuropsychological examinations. A complete neuropsychological examination was con‐

Main outcomes of the study were: Global performance, which was assessed using the Mini Mental State Examination (Folstein et al., 1975), Frontal Assessment Battery (FAB) (Dubois et al., 2000); Semantic and Phonological Fluency, Digit span subtest (digit span forward and backward) and arithmetic subtest (from Wechsler Adult Intelligent Scale-WAIS; Wechsler, 1981); global behavioral symptoms, assessed by the NeuroPsychiatric Inventory, NPI (Cum‐ mings et al., 1994); the caregiver stress, assessed by the Relative Stress Scale, RSS (Green et al., 1992). In addition to these main outcome measures, three further scales were used. The Cornell Scale for Depression in Dementia (Alexopoulos et al., 1988); the Behavioral Patholo‐ gy in Alzheimer's Disease Rating Scale (BEHAVE-AD) (Greene et al., 1982), and the Clinical Insight Rating Scale (CIR) (Ott et al., 1986) (which provides a measure of its four comprising items – awareness, cognitive deficit, disease progression and functional deficit) were per‐ formed. In order to evaluate the apathy, as an independent scale (it is tested as specific item in NPI, and in BEHAVE-AD), we employed the Clinician/Researcher Rated Version of the Apathy Evaluation Scale (AES-C) (Marin et al., 1991). Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS, version 16.0). Within Groups com‐ parisons were performed by Wilcoxon Signed Rank tests. Between-group comparisons of changes were tested using the marginal homogeneity test, employing the Stewart Maxwell test. This was done for the overall scores for each efficacy variable. In addition, sub-analyses of Spearmann's rho correlation, 2-tailed analyses were performed between behavioral data obtained using the Apathy scores (AES-C), the FAB scores, Cornell's Depression Scores, RSS, CIR, and NPI scores. Results are presented as mean changes from baseline with stand‐

The study subjects were 61 AD patients and 310 sVAD patients. All the patients could be fully studied (mean age 71.1 ± 7.3 years, range= 65-94 years). A synopsis of the cognitive per‐ formances obtained by the two groups has been reported in Table 1-2; a synoptic summary of the behavior scores has been reported in Table 3-4; the differential reappraisal of Apathyscores (AES-C) has been reported in table 5-6. In summary, it can be stated that there are some important cognitive differences in the two groups: AD patients did worse in MMSE; they produced lower in phonological and semantic tasks, in arithmetic calculation and in digit tasks of WAIS; sVAD patients did generally worse in FAB tests. From the behavioral

months prior to our assessment.

ducted at baseline, and at 12 months' results were compared.

ard deviations, and P-values are presented where appropriate.

We decided to conduct a prospective cohort study, designed to investigate behavioural al‐ terations, and in particular apathy of an AD and of a sVAD population. Therefore, our group recruited 75 men and women aged 65–94 years, entering in Cognitive Disorder Unit Evaluation of the University of Trieste, with Mini-Mental State Examination (MMSE) scores of at least 14 and satisfying DSM-IV for dementia, and suffering from Alzheimer's Disease, according to NINDCS-ADRDA criteria (McKAhn et al., 1984) and 317 patients suffered from from subcortical vascular dementia, in accordance with the NINDS-AIREN criteria (Román et al., 1993); the patients have been selected from June 1st 2008 to June 1st 2011. In order to be enrolled into the study subjects had to show on brain MRI the classical pattern of atrophy of AD (hippocampal atrophy) and display hypoperfusion in temporoparietal and precuneus regions (AD) on HMPAO-SPECT. A patient was diagnosed as having subcortical VaD (sVaD) when the CT/MRI scan showed moderate to severe ischaemic white matter changes (Erkinjuntti et al., 1997) and at least one lacunar infarct. Brain CT-scans or MRI images were randomized and assessed independently, after the radiologist's opinion, by neurologists (RM, PT, RMA). The diagnosis was confirmed after 6 and 12 months of clinical follow-up.

Patients were not included in the study if they showed signs of normal pressure hydroce‐ phalus, previous brain tumours, previous diagnosis of major stroke or brain haemorrhage. We did not include patients with white matter lesions, caused by specific aetiologies, such as multiple sclerosis, brain irradiation, collagen vascular disease, and genetic forms of vas‐ cular dementia (such as CADASIL or CARASIL). Patients with previous major psychiatric illness (i.e. schizophrenia, bipolar disorders, psychosis, compulsive-obsessive disorders, etc) or central nervous system disorders and alcoholism were excluded too. Exclusion criteria were, in addition to those provided by the corresponding diagnostic criteria, the absence of an informed caregiver, unavailability of neuroradiological examination, and/or the assump‐ tion of psychotropic drugs within two months prior to the clinical assessment. Therefore, five patients were excluded in consequence of lack of a sufficiently informed caregiver and twelve subjects were excluded because they assumed psychotropic drugs during the two months prior to our assessment.

in PD, and is in fact present even in not-purely dopaminergic alterations, such as AD or sVAD (Moretti et al., 2012; Levy et al., 1998; Brown and Pluck, 2000). Existing evidence sug‐ gests that apathy can be related to depression, as a key symptom of major depression or side-effect of antidepressant or antipsychotic drugs (Chase et al., 2011). Though, apathy and depression clearly dissociate in specific motor disorders, such as progressive supranuclear palsy, in which there is a high incidence of apathy but a low incidence of depression (Aars‐ land et al., 2001). Other Authors suggested that apathy might be a consequence of chronic disabling disease and its impact on mobility and opportunity for participation in normal ac‐ tivities. Thus, many Authors used the term "premature social aging" to describe the find‐ ings that patients with apathy have little in the way of interests or social activities, spending more time in solitary activities such as watching television or just sitting doing nothing (Starkstein et al., 1992). If apathy is a primary consequence of physical disability or impair‐ ment in daily living, then similar changes might be predicted for patients with articular/ orthopedic impairment. Surprisingly, the osteoarthritis sample population, despite the mo‐ tor disability, showed no evidence of apathy. It is thus likely that the physiopathology of apathy is a multifaceted entity. The aim of this preliminary was to assess the behavior spec‐ trum of Alzheimer's Disease (AD) and that of subcortical Vascular Dementia (sVAD), with a particular concern for apathy, and to assess its possible role in the differential clinical diag‐ nosis, as compared to other behavioral changes and different neuropsychological patterns.

360 Understanding Alzheimer's Disease

We decided to conduct a prospective cohort study, designed to investigate behavioural al‐ terations, and in particular apathy of an AD and of a sVAD population. Therefore, our group recruited 75 men and women aged 65–94 years, entering in Cognitive Disorder Unit Evaluation of the University of Trieste, with Mini-Mental State Examination (MMSE) scores of at least 14 and satisfying DSM-IV for dementia, and suffering from Alzheimer's Disease, according to NINDCS-ADRDA criteria (McKAhn et al., 1984) and 317 patients suffered from from subcortical vascular dementia, in accordance with the NINDS-AIREN criteria (Román et al., 1993); the patients have been selected from June 1st 2008 to June 1st 2011. In order to be enrolled into the study subjects had to show on brain MRI the classical pattern of atrophy of AD (hippocampal atrophy) and display hypoperfusion in temporoparietal and precuneus regions (AD) on HMPAO-SPECT. A patient was diagnosed as having subcortical VaD (sVaD) when the CT/MRI scan showed moderate to severe ischaemic white matter changes (Erkinjuntti et al., 1997) and at least one lacunar infarct. Brain CT-scans or MRI images were randomized and assessed independently, after the radiologist's opinion, by neurologists (RM, PT, RMA). The diagnosis was confirmed after 6 and 12 months of clinical follow-up.

Patients were not included in the study if they showed signs of normal pressure hydroce‐ phalus, previous brain tumours, previous diagnosis of major stroke or brain haemorrhage. We did not include patients with white matter lesions, caused by specific aetiologies, such as multiple sclerosis, brain irradiation, collagen vascular disease, and genetic forms of vas‐ cular dementia (such as CADASIL or CARASIL). Patients with previous major psychiatric illness (i.e. schizophrenia, bipolar disorders, psychosis, compulsive-obsessive disorders, etc) or central nervous system disorders and alcoholism were excluded too. Exclusion criteria were, in addition to those provided by the corresponding diagnostic criteria, the absence of

Study subjects underwent a standardized baseline assessment that included a detailed histo‐ ry, a physical examination, laboratory tests and psychiatric evaluations. The physical exami‐ nation included evaluations of pulse rate and rhythm, blood pressure, heart size and sounds, peripheral pulses, retinal vessel and carotid artery evaluation, electrocardiographic evaluation, and chest X-ray. All patients were followed with periodical neurological and neuropsychological examinations. A complete neuropsychological examination was con‐ ducted at baseline, and at 12 months' results were compared.

Main outcomes of the study were: Global performance, which was assessed using the Mini Mental State Examination (Folstein et al., 1975), Frontal Assessment Battery (FAB) (Dubois et al., 2000); Semantic and Phonological Fluency, Digit span subtest (digit span forward and backward) and arithmetic subtest (from Wechsler Adult Intelligent Scale-WAIS; Wechsler, 1981); global behavioral symptoms, assessed by the NeuroPsychiatric Inventory, NPI (Cum‐ mings et al., 1994); the caregiver stress, assessed by the Relative Stress Scale, RSS (Green et al., 1992). In addition to these main outcome measures, three further scales were used. The Cornell Scale for Depression in Dementia (Alexopoulos et al., 1988); the Behavioral Patholo‐ gy in Alzheimer's Disease Rating Scale (BEHAVE-AD) (Greene et al., 1982), and the Clinical Insight Rating Scale (CIR) (Ott et al., 1986) (which provides a measure of its four comprising items – awareness, cognitive deficit, disease progression and functional deficit) were per‐ formed. In order to evaluate the apathy, as an independent scale (it is tested as specific item in NPI, and in BEHAVE-AD), we employed the Clinician/Researcher Rated Version of the Apathy Evaluation Scale (AES-C) (Marin et al., 1991). Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS, version 16.0). Within Groups com‐ parisons were performed by Wilcoxon Signed Rank tests. Between-group comparisons of changes were tested using the marginal homogeneity test, employing the Stewart Maxwell test. This was done for the overall scores for each efficacy variable. In addition, sub-analyses of Spearmann's rho correlation, 2-tailed analyses were performed between behavioral data obtained using the Apathy scores (AES-C), the FAB scores, Cornell's Depression Scores, RSS, CIR, and NPI scores. Results are presented as mean changes from baseline with stand‐ ard deviations, and P-values are presented where appropriate.

The study subjects were 61 AD patients and 310 sVAD patients. All the patients could be fully studied (mean age 71.1 ± 7.3 years, range= 65-94 years). A synopsis of the cognitive per‐ formances obtained by the two groups has been reported in Table 1-2; a synoptic summary of the behavior scores has been reported in Table 3-4; the differential reappraisal of Apathyscores (AES-C) has been reported in table 5-6. In summary, it can be stated that there are some important cognitive differences in the two groups: AD patients did worse in MMSE; they produced lower in phonological and semantic tasks, in arithmetic calculation and in digit tasks of WAIS; sVAD patients did generally worse in FAB tests. From the behavioral perspective, the following aspects merged from the study: at baseline, the AD group had a worse score of NPI and BEHAVE-AD, and their caregivers did have a heavier stress, as stat‐ ed by RSS. On the contrary, sVAD patients, at baseline did feel much more depressed (as stated by Cornell'Scale) and did have a better insight in their situation. After 12 months, AD patients showed higher NPI and Behave scores; sVAD patients did show more insight and remained more depressed. Surprisingly, the stress of the caregivers was not significantly dif‐ ferent in the two groups. Very interestingly, sVAD patients did manifest more overt apathy, which merged from the AES-C scores, which increase during follow-up and remained a ma‐ jor key point in behavior disturbances of these patients. Spearman's rank correlation analy‐ ses indicated that there was a significant correlation between AES-C scores and RSS in sVAD (r=0.88, p<0.01); a negative correlation with FAB scores (r=-0.81, p<0.01); analyzing the sub-items, it can be stated a negative relationship between AES-S and C scores and the go/no-go strategies (r=-0.71, p<0.05); there was no relationship between apathy and depres‐ sion and insight ratio.

**12 months follow-up sVAD**

Word phonological fluency (WAIS)\*\* 29.5 (2.3)

Semantic category (WAIS)\*\*\* 27.1 (2.1)

Arithmetic calculations (WAIS) § 5.4 (1.1)

Digit span forward (WAIS) 4.1 (1.4)

Digit span backward (WAIS) 3.6 (0.3)

FAB total score 5.7 (1.5)

Analogies 1.2 (0.1)

Phonemic fluency (0.1)

Motor series 1.1 (0.3)

Go/no-go 0.1 (0.3)

Comprehension 1.0 (0.9)

beginning with T, P, C;

mistakes

Contrast Instructions 1.2 (0.5)

MMSE 23.8 (2.1)

**within group (12 months vs baseline)**

Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular

(-2 (.0.3); p<0.05)

(-5 (5.6); p<0.01)

(-10.6 (3.5); p<0.01)

(-0.9 (0.5); ns)

(-1.7 (0.1); p<0.05)

(-0.8 (2.2); ns)

(-5.5 (0.6); p<0.01)

(-0.8 (0.8); p<0.05)

(-0.5 (0.1); p<0.05)

(-1.1 (0.5); p<0.01)

(-1.1 (0.3); p<0.01)

(-0.7 (0.2); p<0.05)

(-0.9 (0.8); p<0.05)

Values are mean (SD). NS = not significant.. \*Number of items in 45 seconds.; \*\* Total number of words produced,

\*\*\* Total number of words produced, comprised in the following categories: animal, fruits, professions ; § Number of

In brackets, in each column, comparison within group, 12 months vs baseline, reported as mean, SD, and p

**Table 2.** Cognitive synoptical results obtained by the two groups studied, at 12 months

**AD within group (12 months vs baseline)**

> 17.1 (1.7) (-5 (0.2); p<0.01)

16.2 (3.1) (-15 (0.5); p<0.01)

12.6 (1.3) (-9.9 (1.9); p<0.01)

3.4 (1.7) (-5.2 (0.5); p<0.01)

3.2 (0.2) (-1.9 (0.4); p<0.05)

1.9 (0.1) (-0.5 (0.7); p<0.05)

7.5 (0.2) (-3.3 (1.0); p<0.05)

> 1.4 (0.1) (-0.2 (0.2); ns)

1.4 (0.1) (-0.4 (0.1); p<0.05)

1.6 (0.2) (-0.9 (0.2); p<0.05)

> 2.0 (0.1) (-0.2 (0.1); ns)

> 0.8 (0.1) (-0.1 (0.2); ns)

0.3 (0.1) (-0.6 (0.1); p<0.05)

**P value (between group)**

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Dementia

363

<0.01

<0.01

<0.01

<0.05

<0.05

<0.01

<0.01

ns

ns

ns

ns

ns

<0.05


Values are mean (SD). NS = not significant.. \*Number of items in 45 seconds.; \*\* Total number of words produced, beginning with T, P, C;

\*\*\* Total number of words produced, comprised in the following categories: animal, fruits, professions ; § Number of mistakes

**Table 1.** Cognitive synoptical results obtained by the two groups studied

Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular Dementia http://dx.doi.org/10.5772/54264 363

perspective, the following aspects merged from the study: at baseline, the AD group had a worse score of NPI and BEHAVE-AD, and their caregivers did have a heavier stress, as stat‐ ed by RSS. On the contrary, sVAD patients, at baseline did feel much more depressed (as stated by Cornell'Scale) and did have a better insight in their situation. After 12 months, AD patients showed higher NPI and Behave scores; sVAD patients did show more insight and remained more depressed. Surprisingly, the stress of the caregivers was not significantly dif‐ ferent in the two groups. Very interestingly, sVAD patients did manifest more overt apathy, which merged from the AES-C scores, which increase during follow-up and remained a ma‐ jor key point in behavior disturbances of these patients. Spearman's rank correlation analy‐ ses indicated that there was a significant correlation between AES-C scores and RSS in sVAD (r=0.88, p<0.01); a negative correlation with FAB scores (r=-0.81, p<0.01); analyzing the sub-items, it can be stated a negative relationship between AES-S and C scores and the go/no-go strategies (r=-0.71, p<0.05); there was no relationship between apathy and depres‐

**baseline sVAD AD P value**

MMSE 25.8 (2.4) 22.1 (1.9) <0.05

Word phonological fluency (WAIS)\*\* 34.5 (7.9) 31.2 (3.6) ns

Semantic category (WAIS)\*\*\* 37.7 (5.6) 24.5 (3.2) <0.01 Arithmetic calculations (WAIS) § 6.3 (1.6) 8.6 (1.2) <0.05

Digit span forward (WAIS) 5.8 (1.5) 5.1 (0.6) <0.05 Digit span backward (WAIS) 4.4 (2.5) 2.6 (0.8) <0.05

FAB total score 11.2 (2.1) 10.8 (1.2) ns Analogies 2 (0.9) 1.6 (0.2) ns

Phonemic fluency 1.6 (0.2) 1.8 (0.2) ns Motor series 2.2 (0.1) 2.7 (0.4) ns

Contrast Instructions 2.3 (0.3) 2.2 (0.2) ns

Values are mean (SD). NS = not significant.. \*Number of items in 45 seconds.; \*\* Total number of words produced,

\*\*\* Total number of words produced, comprised in the following categories: animal, fruits, professions ; § Number of

**Table 1.** Cognitive synoptical results obtained by the two groups studied

Go/no-go 0.8 (0.5) 0.9 (0.3) ns Comprehension 1.9 (0.1) 0.9 (0.2) <0.05

**(between group)**

sion and insight ratio.

362 Understanding Alzheimer's Disease

beginning with T, P, C;

mistakes


Values are mean (SD). NS = not significant.. \*Number of items in 45 seconds.; \*\* Total number of words produced, beginning with T, P, C;

\*\*\* Total number of words produced, comprised in the following categories: animal, fruits, professions ; § Number of mistakes

In brackets, in each column, comparison within group, 12 months vs baseline, reported as mean, SD, and p

**Table 2.** Cognitive synoptical results obtained by the two groups studied, at 12 months


What merged from this study is a confirmation of the wide known rule, that behavioral dis‐ orders are the most problematic in the follow-up of dementia. Among them, apathy is one of the most concerning. Frequency and severity of apathy vary across different dementia sub‐ types; it is the most common behavioral symptom of behavioral variant of frontotemporal dementia (bvFTD), with reported prevalence ranging from 62 to 89% of patients (Mendez et al., 2008); the prevalence of apathy in AD ranges from 25 to 88% with a trend to increase with disease severity (Starkestein et al., 2006). The prevalence of apathy in other neuro-de‐ generative disorders, such as Parkinson's disease vary between 16.5% and 51%, depending upon the instrument for assessment and on the samples examined (Moretti et al., 2012). Apathy may be associated with an increased risk of cognitive decline. Symptoms of apathy, but not symptoms of depressive affect, increase the risk of progression from MCI to AD (Richard et al., 2012). Conversely, patients with or without apathy had an increase of similar magnitude in anosognosia scores. In conclusion, anosognosia is a significant predictor of

Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular

Dementia

365

http://dx.doi.org/10.5772/54264

The aim of our study was to assess the behavior spectrum of Alzheimer's Disease (AD) and that of subcortical Vascular Dementia (sVAD), with a particular concern for apathy, and to assess the possible role of apathy in the differential clinical diagnosis, as compared to other behavioral changes and different neuropsychological patterns. Our results showed that there are some important cognitive differences in the two groups. Obviously, the AD pa‐ tients did worse in MMSE; they produced lower in phonological and semantic tasks, they did many mistakes in arithmetic calculation and their digit span were lower; sVAD patients did generally worse in FAB tests, as a sensitive measure of executive dysfunction. And their behavior problems were different. At baseline, the AD group had a worse score of NPI and BEHAVE-AD, and their caregivers did have a heavier stress, as stated by RSS. On the con‐ trary, sVAD patients, at baseline did feel much more depressed (as stated by Cornell'Scale) and did have a better insight in their situation. After 12 months, AD patients showed higher NPI and Behave scores; sVAD patients did show more insight and remained more de‐ pressed. Surprisingly, the stress of the caregivers was not significantly different in the two groups. Very interestingly, sVAD patients did manifest more overt apathy, which merged

So far, it can be argued that sVAD patients have higher insight, more depression and more apathy than AD, and the two last aspects are the major causative factors for an increase of caregiver stress in the one-year follow-up. At that time, the significant difference which was noted at the beginning of the study for the RSS of AD patients, is practically cancelled out, and there is no difference between RSS in AD and sVAD patients. The main reason for what observed is that apathy increases, and caregivers do not know how to manage it. Apathy is one of the greatest stressors for caregivers, and the second most common is disinhibition

As a general observation (Quaranta et al., 2012), the occurrence of apathy is connected to dam‐ age of prefrontal cortex (PFC) and basal ganglia (Chase, 2011); "emotional affective" apathy may be related to the orbitomedial PFC and ventral striatum; "cognitive apathy" may be associ‐ ated with dysfunction of lateral PFC and dorsal caudate nuclei; deficit of "autoactivation" may

apathy in Alzheimer's disease (Starkstein et al., 2010).

from the AES-C scores, which increased during follow-up.

(Massimo et al., 2009).

Values are mean (SD). NS = not significant..

#### **Table 3.** Behavioral synoptical results


Values are mean (SD). NS = not significant.; In brackets, in each column, comparison within group, 12 months vs base‐ line, reported as mean, SD, and p

#### **Table 4.** Behavioral synoptical results


Values are mean (SD). NS = not significant.

#### **Table 5.** Apathy scores, by the researcher evaluation (AES-C)


**Table 6.** Values are mean (SD). NS = not significant.. In brackets, in each column, comparison within group, 12 months vs baseline, reported as mean, SD, and p

What merged from this study is a confirmation of the wide known rule, that behavioral dis‐ orders are the most problematic in the follow-up of dementia. Among them, apathy is one of the most concerning. Frequency and severity of apathy vary across different dementia sub‐ types; it is the most common behavioral symptom of behavioral variant of frontotemporal dementia (bvFTD), with reported prevalence ranging from 62 to 89% of patients (Mendez et al., 2008); the prevalence of apathy in AD ranges from 25 to 88% with a trend to increase with disease severity (Starkestein et al., 2006). The prevalence of apathy in other neuro-de‐ generative disorders, such as Parkinson's disease vary between 16.5% and 51%, depending upon the instrument for assessment and on the samples examined (Moretti et al., 2012). Apathy may be associated with an increased risk of cognitive decline. Symptoms of apathy, but not symptoms of depressive affect, increase the risk of progression from MCI to AD (Richard et al., 2012). Conversely, patients with or without apathy had an increase of similar magnitude in anosognosia scores. In conclusion, anosognosia is a significant predictor of apathy in Alzheimer's disease (Starkstein et al., 2010).

**baseline sVAD AD P value** RSS **24.7 (8.7) 36.1 ( 8.5)** (p<0.01) NPI **14.9 (0.3) 24.4 (5.2)** (p<0.01) CIR **3 (0.2) 2 (0.5)** (p<0.05) Cornell **18.5 (3.5) 13.5 (4)** (p<0.05) BEHAVE **9.5 (2.1) 12.6 (4.1)** (p<0.05)

Values are mean (SD). NS = not significant.; In brackets, in each column, comparison within group, 12 months vs base‐

**baseline sVAD AD P value** AES-C 48.5 (7.2) 28.0 (4.9) <0.01

**Table 6.** Values are mean (SD). NS = not significant.. In brackets, in each column, comparison within group, 12 months

**sVAD AD P value**

43.9 (2.1) (+7.8 (6.8), <0.05)

56.3 (4.5) (+31.9 (1.1), <0.01)

(0.3) (+1.0 (0.3), <0.05)

> 12.3 (1.1) (-0.8 (3.1), ns)

43.1 (2.3) (+30.5 (0.8), <0.01)

**sVAD AD P value**

33.4 (6.1) (5.4 (1.2); ns) ns

(p<0.01)

(p<0.01)

(p<0.01)

(p<0.01)

<0.01

Values are mean (SD). NS = not significant..

RSS 44.5 (1.6)

NPI 24.1 (0.8)

CIR 2.7 (0.3)

Cornell 22.1 (1.2)

BEHAVE 22.7 (1.3)

line, reported as mean, SD, and p

**Table 4.** Behavioral synoptical results

Values are mean (SD). NS = not significant.

**Table 5.** Apathy scores, by the researcher evaluation (AES-C)

AES-C 67.2 (3.5)

Apathy scores, by the researcher evaluation (AES-C)

vs baseline, reported as mean, SD, and p

(+18.7 (3.7); p<0.01)

(+20.2 (5.9), <0.01)

(+10.8 (0.5), <0.01)

(+0.3 (0.1), ns)

(+4.4 (2.3), <0.05)

(+13.2 (0.8), <0.01)

**Table 3.** Behavioral synoptical results

364 Understanding Alzheimer's Disease

The aim of our study was to assess the behavior spectrum of Alzheimer's Disease (AD) and that of subcortical Vascular Dementia (sVAD), with a particular concern for apathy, and to assess the possible role of apathy in the differential clinical diagnosis, as compared to other behavioral changes and different neuropsychological patterns. Our results showed that there are some important cognitive differences in the two groups. Obviously, the AD pa‐ tients did worse in MMSE; they produced lower in phonological and semantic tasks, they did many mistakes in arithmetic calculation and their digit span were lower; sVAD patients did generally worse in FAB tests, as a sensitive measure of executive dysfunction. And their behavior problems were different. At baseline, the AD group had a worse score of NPI and BEHAVE-AD, and their caregivers did have a heavier stress, as stated by RSS. On the con‐ trary, sVAD patients, at baseline did feel much more depressed (as stated by Cornell'Scale) and did have a better insight in their situation. After 12 months, AD patients showed higher NPI and Behave scores; sVAD patients did show more insight and remained more de‐ pressed. Surprisingly, the stress of the caregivers was not significantly different in the two groups. Very interestingly, sVAD patients did manifest more overt apathy, which merged from the AES-C scores, which increased during follow-up.

So far, it can be argued that sVAD patients have higher insight, more depression and more apathy than AD, and the two last aspects are the major causative factors for an increase of caregiver stress in the one-year follow-up. At that time, the significant difference which was noted at the beginning of the study for the RSS of AD patients, is practically cancelled out, and there is no difference between RSS in AD and sVAD patients. The main reason for what observed is that apathy increases, and caregivers do not know how to manage it. Apathy is one of the greatest stressors for caregivers, and the second most common is disinhibition (Massimo et al., 2009).

As a general observation (Quaranta et al., 2012), the occurrence of apathy is connected to dam‐ age of prefrontal cortex (PFC) and basal ganglia (Chase, 2011); "emotional affective" apathy may be related to the orbitomedial PFC and ventral striatum; "cognitive apathy" may be associ‐ ated with dysfunction of lateral PFC and dorsal caudate nuclei; deficit of "autoactivation" may be due to bilateral lesions of the internal portion of globus pallidus, bilateral paramedian thala‐ mic lesions, or the dorsomedial portion of PFC (Chow et al. 2009). Trying to compare apathy in AD and in the behavior form of Frontal dementia (bvFTD), Quaranta et al (2012) lead to an ob‐ servation of a different distribution of apathetic symptoms; they stated that subjects affected by bvFTD displayed higher frequency of "affective" symptoms, and a reduction of "auto-activa‐ tion" (Levy and Dubois, 2006) (or "behavioral apathy," (Marin, 1991)) in comparison with AD sample. The different clinical expression of apathy, among the two groups of patients probably reflects the involvement of different anatomic substrates. Previous studies have reported that in bvFTD apathy is associated with changes in orbitofrontal cortex (Zamboni et al., 2008; Peters et al., 2006), which, in turn, has been postulated to be the anatomical correlate of "affective" apathy (Levy and Dubois, 2006), and with volume loss in the dorsal anterior cingulate and dor‐ solateral prefrontal cortex (Massimo et al., 2009). Thus, it is possible that the observation by Quaranta et al (2012) may reflect an alteration of orbitofrontal cortex and its connections with subcortical nuclei (ventral striatum), that could be specific of bvFTD. "Affective apathy" may be also regarded as the clinical expression of personality changes in bvFTD; for example, Sol‐ lberger et al. (2009) reported that subjects with FTD and semantic dementia displayed a reduc‐ tion in affiliative behavior (lack of warmth) and showed, in a large sample of subjects aff ected by different neurodegenerative diseases, an association between "warmth" and several cortical and subcortical right hemisphere structures (viz. orbitofrontal cortex, insular cortex, amygda‐ la, and hippocampal and parahippocampal regions). This finding is of particular interest, since the authors reported an association between lack of warmth and cerebral structures related to reward mechanisms, and "affective apathy" has been regarded as consequence of the inability to associate emotions to behaviors (Marin, 1991; 1996). Analogously, affective apathy may be related to an impairment of the so-called prosocial sentiments (such as guilt, pity, and embar‐ rassment), connected to lack of empathy; Moll et al. (2011) reported reduced social sentiments in bvFTD subjects; this deficit was related to hypometabolism in medial frontal polar cortex and septal area.

reported (Apostolova et al., 2007; Bruen et al., 2008) as is atrophy of frontopolar (BA 10) and ventrolateral prefrontal regions, including BA 45 (pars triangularis; Bruen et al., 2008).

Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular

Dementia

367

http://dx.doi.org/10.5772/54264

Also of note, is some evidence that subcortical nuclei which project to prefrontal regions, in‐ cluding the caudate and putamen have shown greater atrophy in apathy in AD (Bruen et al., 2008). Overall then, functional, structural and pathological studies point towards a specific involvement of the ACC and OFC in mediating symptoms of apathy, with a suggestion of

One pathophysiological model for apathy in Alzheimer's disease which addresses both structural and biochemical disruption is that of Guimaraes et al. (2008). Their model propos‐ es that the ACC and OFC are part of a broader fronto striatal circuit, which is involved in decision-making. Specifically, these regions are involved in evaluating action and outcomes and, via the basolateral amygdala and nucleus accumbens, feed into an ascending frontos‐ triatal pathway to the dorsolateral prefrontal cortex, which is ultimately responsible for se‐ lecting and executing behavioural responses. Damage to the ACC and OFC leads to a disruption of this circuit resulting in impaired decision-making and impaired response ini‐

This model resembles quite well our idea of apathy in sVAD. There is good evidence of high levels of apathy subcortical disease, such as Parkinson's Disease, resulting from dysfunction at the striatal level (Pluck and Brown, 2002), and our data suggest than in AD the locus of

In sVAD, apathy might be the result of a wider prefrontal disease process, or may suggest a pu‐ tative role for these regions in mediating apathy, namely due to an involvement of the pars tri‐ angularis, of the superior frontal gyrus and of the orbital operculum may suggest that degeneration of the OFC is part of. Ventrolateral and superior frontal regions are also involved in the selection and execution of willed action, and so may contribute to the diminished behav‐ ioural responses to everyday challenges displayed by apathetic patients. Recently, increased incidence of white matter hyperintensities in the frontal lobe has been associated with apathy (Starkstein et al., 2009); however, some studies have found no evidence of frontal involvement in apathy (Rosen et al., 2005). A recent and well conducted study examined the relationship be‐ tween behavior alterations and subcortical lesions (white-matter lesions and lacunes) in AD (Palmqvist et al., 2011). Lacunes in the basal ganglia resulted in a 2- to 3-fold increased risk of delusions, hallucinations and depression, when adjusting for cognition and atrophy. This sug‐ gests that basal ganglia lesions can contribute to BPSD in patients with AD, independently of

Being that we have chosen sVAD and AD patients, we have tried to avoid the spurious cases of AD/sVAD coexistence. What we have found is a major involvement of subcortical frontal cir‐ cuits in sVAD, than in AD, and deriving from that, major evidence of apathy in sVAD, than in AD. In normal conditions, one may propose that the prefrontal cortex internalizes the informa‐ tion from the external and internal environments needed to make a decision about possible ac‐ tions to be elaborated and performed. Neural signals corresponding to the thoughts or actions are then processed by the basal ganglia in order to validate the most relevant signal. Validation processing may be translated into the extraction of the relevant signal from noise to be read‐

dysfunction is at the cortical level, namely the ACC and the OFC.

wider involvement of frontocortical networks.

tiation, which presents as apathy.

the AD process (Palmqvist et al., 2011).

On the other hand, in AD, apathy severity has been connected to neurofibrillary tangles density in the anterior cingulate gyrus (Marshall et al., 2006) and to grey matter atrophy in the anterior cingulate and in the left medial frontal cortex (Apostolova et al, 2007; Tekin et al., 2001; Marshall et al., 2006). These findings were confirmed by a PET study showing the association of apathy with hypometabolism in the bilateral anterior cingulate gyrus and me‐ dial orbitofrontal cortex (Marshall et al., 2007). Many studies tried to identify the neuroana‐ tomical correlates of apathy in AD (Tunnard et al., 2011). Functional imaging studies have tended to find impaired functioning measured by either reduced blood flow or reduced me‐ tabolism in the anterior cingulate cortex (ACC) and medial frontal or orbitofrontal cortical (OFC) brain regions (Robert et al., 2006; Lanctot et al., 2007; Marshall et al., 2007). However, it is uncertain whether these regions are unilaterally or bilaterally affected. Others have found reduced function limited to the OFC alone (Holthoff et al., 2005) or the ACC alone (Migneco et al., 2001), suggesting that impaired functioning of both regions is not necessary for apathy to result. MRI studies investigating the structural correlates of apathy in AD pa‐ tients have, for the most part, replicated findings from functional studies implicating the ACC and OFC most consistently (Apostolova et al., 2007;Laveretsky et al., 2007; Bruen et al., 2008). Additional regions of atrophy in the superior frontal gyrus, specifically BA 9, are also reported (Apostolova et al., 2007; Bruen et al., 2008) as is atrophy of frontopolar (BA 10) and ventrolateral prefrontal regions, including BA 45 (pars triangularis; Bruen et al., 2008).

be due to bilateral lesions of the internal portion of globus pallidus, bilateral paramedian thala‐ mic lesions, or the dorsomedial portion of PFC (Chow et al. 2009). Trying to compare apathy in AD and in the behavior form of Frontal dementia (bvFTD), Quaranta et al (2012) lead to an ob‐ servation of a different distribution of apathetic symptoms; they stated that subjects affected by bvFTD displayed higher frequency of "affective" symptoms, and a reduction of "auto-activa‐ tion" (Levy and Dubois, 2006) (or "behavioral apathy," (Marin, 1991)) in comparison with AD sample. The different clinical expression of apathy, among the two groups of patients probably reflects the involvement of different anatomic substrates. Previous studies have reported that in bvFTD apathy is associated with changes in orbitofrontal cortex (Zamboni et al., 2008; Peters et al., 2006), which, in turn, has been postulated to be the anatomical correlate of "affective" apathy (Levy and Dubois, 2006), and with volume loss in the dorsal anterior cingulate and dor‐ solateral prefrontal cortex (Massimo et al., 2009). Thus, it is possible that the observation by Quaranta et al (2012) may reflect an alteration of orbitofrontal cortex and its connections with subcortical nuclei (ventral striatum), that could be specific of bvFTD. "Affective apathy" may be also regarded as the clinical expression of personality changes in bvFTD; for example, Sol‐ lberger et al. (2009) reported that subjects with FTD and semantic dementia displayed a reduc‐ tion in affiliative behavior (lack of warmth) and showed, in a large sample of subjects aff ected by different neurodegenerative diseases, an association between "warmth" and several cortical and subcortical right hemisphere structures (viz. orbitofrontal cortex, insular cortex, amygda‐ la, and hippocampal and parahippocampal regions). This finding is of particular interest, since the authors reported an association between lack of warmth and cerebral structures related to reward mechanisms, and "affective apathy" has been regarded as consequence of the inability to associate emotions to behaviors (Marin, 1991; 1996). Analogously, affective apathy may be related to an impairment of the so-called prosocial sentiments (such as guilt, pity, and embar‐ rassment), connected to lack of empathy; Moll et al. (2011) reported reduced social sentiments in bvFTD subjects; this deficit was related to hypometabolism in medial frontal polar cortex

On the other hand, in AD, apathy severity has been connected to neurofibrillary tangles density in the anterior cingulate gyrus (Marshall et al., 2006) and to grey matter atrophy in the anterior cingulate and in the left medial frontal cortex (Apostolova et al, 2007; Tekin et al., 2001; Marshall et al., 2006). These findings were confirmed by a PET study showing the association of apathy with hypometabolism in the bilateral anterior cingulate gyrus and me‐ dial orbitofrontal cortex (Marshall et al., 2007). Many studies tried to identify the neuroana‐ tomical correlates of apathy in AD (Tunnard et al., 2011). Functional imaging studies have tended to find impaired functioning measured by either reduced blood flow or reduced me‐ tabolism in the anterior cingulate cortex (ACC) and medial frontal or orbitofrontal cortical (OFC) brain regions (Robert et al., 2006; Lanctot et al., 2007; Marshall et al., 2007). However, it is uncertain whether these regions are unilaterally or bilaterally affected. Others have found reduced function limited to the OFC alone (Holthoff et al., 2005) or the ACC alone (Migneco et al., 2001), suggesting that impaired functioning of both regions is not necessary for apathy to result. MRI studies investigating the structural correlates of apathy in AD pa‐ tients have, for the most part, replicated findings from functional studies implicating the ACC and OFC most consistently (Apostolova et al., 2007;Laveretsky et al., 2007; Bruen et al., 2008). Additional regions of atrophy in the superior frontal gyrus, specifically BA 9, are also

and septal area.

366 Understanding Alzheimer's Disease

Also of note, is some evidence that subcortical nuclei which project to prefrontal regions, in‐ cluding the caudate and putamen have shown greater atrophy in apathy in AD (Bruen et al., 2008). Overall then, functional, structural and pathological studies point towards a specific involvement of the ACC and OFC in mediating symptoms of apathy, with a suggestion of wider involvement of frontocortical networks.

One pathophysiological model for apathy in Alzheimer's disease which addresses both structural and biochemical disruption is that of Guimaraes et al. (2008). Their model propos‐ es that the ACC and OFC are part of a broader fronto striatal circuit, which is involved in decision-making. Specifically, these regions are involved in evaluating action and outcomes and, via the basolateral amygdala and nucleus accumbens, feed into an ascending frontos‐ triatal pathway to the dorsolateral prefrontal cortex, which is ultimately responsible for se‐ lecting and executing behavioural responses. Damage to the ACC and OFC leads to a disruption of this circuit resulting in impaired decision-making and impaired response ini‐ tiation, which presents as apathy.

This model resembles quite well our idea of apathy in sVAD. There is good evidence of high levels of apathy subcortical disease, such as Parkinson's Disease, resulting from dysfunction at the striatal level (Pluck and Brown, 2002), and our data suggest than in AD the locus of dysfunction is at the cortical level, namely the ACC and the OFC.

In sVAD, apathy might be the result of a wider prefrontal disease process, or may suggest a pu‐ tative role for these regions in mediating apathy, namely due to an involvement of the pars tri‐ angularis, of the superior frontal gyrus and of the orbital operculum may suggest that degeneration of the OFC is part of. Ventrolateral and superior frontal regions are also involved in the selection and execution of willed action, and so may contribute to the diminished behav‐ ioural responses to everyday challenges displayed by apathetic patients. Recently, increased incidence of white matter hyperintensities in the frontal lobe has been associated with apathy (Starkstein et al., 2009); however, some studies have found no evidence of frontal involvement in apathy (Rosen et al., 2005). A recent and well conducted study examined the relationship be‐ tween behavior alterations and subcortical lesions (white-matter lesions and lacunes) in AD (Palmqvist et al., 2011). Lacunes in the basal ganglia resulted in a 2- to 3-fold increased risk of delusions, hallucinations and depression, when adjusting for cognition and atrophy. This sug‐ gests that basal ganglia lesions can contribute to BPSD in patients with AD, independently of the AD process (Palmqvist et al., 2011).

Being that we have chosen sVAD and AD patients, we have tried to avoid the spurious cases of AD/sVAD coexistence. What we have found is a major involvement of subcortical frontal cir‐ cuits in sVAD, than in AD, and deriving from that, major evidence of apathy in sVAD, than in AD. In normal conditions, one may propose that the prefrontal cortex internalizes the informa‐ tion from the external and internal environments needed to make a decision about possible ac‐ tions to be elaborated and performed. Neural signals corresponding to the thoughts or actions are then processed by the basal ganglia in order to validate the most relevant signal. Validation processing may be translated into the extraction of the relevant signal from noise to be read‐ dressed to the output target, namely the prefrontal cortex (Levy and Dubois, 2006), where a clear-cut signal can be detected and contributes to disambiguating decision-making and main‐ taining or modifying the ongoing behaviour. In pathological situations, if there is a focal de‐ struction within the basal ganglia sub-regions, the signal emerging from the basal ganglia is diminished, the ongoing behaviour is not validated (i.e. not amplified) at the level of the cortex and could be difficult to maintain, and the forthcoming one (if it is not reflexive) is not activated (Levy and Dubois, 2006). In sum, an 'auto-activation' deficit results from the inability of volun‐ tary thoughts or actions to reach the activation threshold due to a decreased signal-to-noise ra‐ tio at the level of the prefrontal cortex (Levy and Dubois, 2006).

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Thus, in that way, we can justify apathy in sVAD due to the major involvement of corticalsubcortical neural pathways. Many studies should be done to differentiate the anatomical, biological, and physiological eventual different substrate in the subcortical vascular forms, and in degenerative disorders, in order to better differentiate them, if necessary, and eventu‐ ally to treat them.

### **Acknowledgements**

The Authors wish to thank Andrew Wright Smithson, PhD for the careful reading and cor‐ rections of the manuscript.
