Contents

#### **Preface XIII**


Chapter 6 **Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple Mechanisms 109** Lucia Pastorino, Asami Kondo, Xiao Zhen Zhou and Kun Ping Lu

### Chapter 7 **Alzheimer Disease and Metabolism: Role of Cholesterol and Membrane Fluidity 145**

Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Luis J. Flores-Alvarado, Miguel A. Macías-Islas, Irma E. Velázquez-Brizuela, Ana C. Ramírez-Anguiano, Erandis D. Tórres-Sánchez, Eddic W. Moráles-Sánchez, José A. Cruz-Ramos, Genaro E Ortiz-Velázquez and Fernando Cortés-Enríquez

Chapter 14 **Apathy as a Key Symptom in Behavior Disorders: Difference**

Chapter 15 **Predicting Cognitive Decline in Alzheimer's Disease (AD): The**

Chapter 17 **Prevention of Alzheimer's Disease: Intervention Studies 451** Francesca Mangialasche, Weili Xu and Miia Kivipelto

Tomietto and Rodolfo M. Antonello

Mei Sian Chong and Tih-Shih Lee

Chapter 16 **Alzheimer's Disease and Diabetes 409**

**Dementia 359**

Glazner

**Between Alzheimer's Disease and Subcortical Vascular**

Rita Moretti, Paola Torre, Francesca Esposito, Enrica Barro, Paola

Contents **VII**

**Role of Clinical, Cognitive Characteristics and Biomarkers 375**

Brent D. Aulston, Gary L. Odero, Zaid Aboud and Gordon W.

#### **Section 2 Diagnosis 175**

Chapter 8 **Pre-Analytical and Analytical Critical Factors Influencing the High Variability of the Concentrations Levels of Alzheimer Disease Biomarkers in Cerebral Spinal Fluid 177** Armand Perret-Liaudet, Aline Dorey, Yannick Tholance, Benoit Dumont and Isabelle Quadrio

	- **Section 3 Therapy 249**

Chapter 14 **Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular Dementia 359** Rita Moretti, Paola Torre, Francesca Esposito, Enrica Barro, Paola Tomietto and Rodolfo M. Antonello

Chapter 7 **Alzheimer Disease and Metabolism: Role of Cholesterol and**

Chapter 8 **Pre-Analytical and Analytical Critical Factors Influencing the**

**Disease Biomarkers in Cerebral Spinal Fluid 177**

Chapter 10 **Using Magnetic Resonance Imaging in the Early Detection of**

Emily J. Mason, Manus J. Donahue and Brandon A. Ally

Chapter 11 **Potential Therapeutic Strategies to Prevent the Progression of**

**Section 4 Epidemiology, Clinical Presentation and Prevention 327**

Weili Xu, Camilla Ferrari and Hui-Xin Wang

Sibel Cevizci, Halil Murat Sen, Fahri Güneş and Elif Karaahmet

Chapter 9 **Candidate Bio-Markers of Alzheimer's Disease 193**

**High Variability of the Concentrations Levels of Alzheimer**

Armand Perret-Liaudet, Aline Dorey, Yannick Tholance, Benoit

Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Luis J. Flores-Alvarado, Miguel A. Macías-Islas, Irma E. Velázquez-Brizuela, Ana C. Ramírez-Anguiano, Erandis D. Tórres-Sánchez, Eddic W. Moráles-Sánchez, José A. Cruz-Ramos, Genaro E Ortiz-Velázquez and Fernando

**Membrane Fluidity 145**

Dumont and Isabelle Quadrio

**Alzheimer's Disease 225**

Ester Aso and Isidre Ferrer

Chapter 12 **Animal Assisted Therapy and Activities in Alzheimer's Disease 303**

Chapter 13 **Epidemiology of Alzheimer's Disease 329**

B.K. Binukumar and Harish C. Pant

**Alzheimer to Disease States 251**

Cortés-Enríquez

**Section 2 Diagnosis 175**

**VI** Contents

**Section 3 Therapy 249**


Preface

This book spans a variety of approaches to address the complex problem of Alzheimer´s disease - what is the cause, is there a single pathogenetic pathways or are there many of them, how can we address the whole clinical spectrum of the disease, how can the disease be diagnosed early and reliable and which perspectives we have for prevention and treat‐ ment. The collection covers actual topics of interest for basic researcher, clinicians, epidemi‐

**Inga Zerr, MD**

Germany

Department of Neurology Cliical Dementia Center

Georg August University Göttingen

ologists and provides insight to various aspects of the disease.
