Contents

#### **Preface XI**



Preface

T-cell leukemia is relativelyrare malignancyof thymocytes. There are around 20 entities and variants of this disease. Each of them has different characteristics, including pathogenesis, epidemiology, diagnosis, therapeutic approaches, andprognosis. Although T-cell leukemia is relatively rare malignancy, many types of T-cell leukemiasstill havea very poor prognosis‐ due to rapid progression. Therefore, development of novel therapeutic and preventive strat‐ egies is necessary to improve prognosis. The purpose of this book entitled "T-Cell Leukemia - Characteristics, Treatment and Prevention"is to provide a comprehensive overview of the disease from the basics of pathogenesis, epidemiology, morphology, and immunological features. This book also highlights the most recent achievements from basic and clinical re‐

The present book features contributions from international authors in various clinical and research fields of T-cell leukemia.The first chapter, "Molecular Pathogenesis of T-Cell leuke‐ mia" by Drs. Michael Litt, Bhavita Patel, Ying Li Yi Qiu and Suming Huang, provides an overview of molecular changesassociated withpathogenesisof T-cell acute leukemia (T-ALL).Specifically, chromosomal translocations which involve rearrangement of T-cell recep‐ tors and gene mutations which deregulate importantsignaling pathways involved in T-cell leukemogenesisare described. The second chapter, "Monoclonal Antibody Therapy of T-cell Leukemia and Lymphoma"writtenby Drs. TahirLatif, and John C. Morris, focuses on the current status of monoclonal antibody therapy of T-cell leukemia and lymphoma.A number of antibodies, including anti-CD2, anti-CD3, anti-CD4, anti-CD5, anti-CD25, anti-CD30, anti-CD52, anti-CD122, and anti-CCR4, which are currently studied for antibody therapy of Tcell leukemia and lymphoma are summarized.Chapter 3, "T- and NK/T-Cell Leukemia in East Asia"was written by Drs. Tsung-Hsien Lin, Yen-Chuan Hsieh, Sheng-Tsung Chang,and Shih-Sung Chuang.The countries in East Asia have higher relative frequencies of these types of leukemias and there are some differences in the clinical and pathological characteristics between Western and Asian countries.This chapter gives usan overview of clinico-patholog‐

search including molecular mechanisms and novel therapies of T-cell leukemia.

ical analysis of various types of T- and NK/T-cell leukemias in the East Asia.

The next four chapters cover the topics of human T-cell leukemia virus type 1(HTLV-1) and adult T-cell leukemia/lymphoma (ATLL).Chapter 4, "Htlv-1-tax--all-roads-lead-to-transfor‐ mation" by Drs. Kendle Pryor and Susan J. Marriott, describes contribution of HTLV-1 viral protein Tax to transformation of HTLV-1 infected cells. In this chapter, cellular transforma‐ tion by Tax both in tissue culture and transgenic mouse models are summarized.The molec‐ ular mechanisms of Tax mediated transformation isalso described from several aspects, such as transcription factors, DNA repair pathways, and cell cycle regulation.Chapter 5,"Glycan Profiling Analysis of Adult T-cell Leukemia (ATL) Cells with the High Resolution Lectin Microarrays"is written by Drs. HidekatsuIha and Masao Yamada. Glycans have been con‐
