**6. Autonomic imaging**

There is evidence that regional and global sympathetic denervation could predispose to ven‐ tricular arrhythmias in post-MI patients. The denervated but viable myocardium could be hyperresponsive to circulating catecholamines [58, 59].

Using imaging methods for the evaluation of the sympathetic system in vivo, in human and animal models, such as [12]3I-mIBG cardiac imaging, it has been reported that the mismatch between sympathetic innervation and perfusion could be associated with increased risk of ventricular arrhythmias.

The extent of sympathetic denervation measured at 4-Hour delayed 123I-mIBG SPECT imag‐ ing has been correlated with inducibility of ventricular arrhythmias in electrophysiological testing [60]. In another study including patients with advanced heart failure, late [12]3I-MIBG SPECT defect score was also an independent predictor for ventricular arrhythmias causing appropriate ICD therapy (primary end point) as well as the composite of appropri‐ ate ICD therapy or cardiac death (secondary end point) [27]

More studies are required to determine the role of autonomic imaging in post-MI patients, possibly detailing their correlation with CMR findings.
