**3. Performing DFT testing**

Before doing DFT testing, consent should be taken from the patient explaining the risk and benefit of the procedure. Vital signs should be stable and basic lab results such as electro‐ lytes should be within normal range. There should be no contraindication to performing the test such as severe aortic stenosis or intracavitary thrombus. An external defibrillator should be placed ready next to the patient, preferably with defibrillator patches attached to the pa‐ tient. As the shock is painful, adequate sedation or short anesthesia should be given with careful monitoring of vital signs and saturation level [14].

After the device is implanted good lead position should be verified by X-ray. The lead is tested to ensure adequate sensing and pacing thresholds and normal impedance values.

Prior to VF induction, the device is activated and programmed with the amount of energy to be delivered. Ventricular fibrillation is usually induced via the device. There are several methods of VF induction such as programmed ventricular stimulation, T wave shock, fast burst pacing, or by applying low voltage direct current [15]. Following VF induction the pa‐ tient is monitored carefully until the device detects the arrhythmia and restores it back to sinus rhythm. If the device fails, external defibrillation should be immediately performed.

To find the exact DFT value, this process has to be repeated several times with either a step up, step down, or a binary fashion until DFT or ULV are found [16-17]. Although the term threshold should indicate a value above which defibrillation is successful and below which shocks fail, in reality DFT is a probabilistic phenomenon with a certain percentage of success rate [17-18]. One shock may be successful while a successive one with the same conditions may fail [5]. Despite the poor reproducibility of DFT, it is still a useful parameter, as this val‐ ue taken with a safety margin above it, gives a high clinical success of VF termination. The standard safety margin is 10 J, although 5 J may be enough [19-20].

DFT testing with several shocks and titrations may be useful in a research protocol, where the exact value has important clinical significance. A simpler, yet safe approach is the defib‐ rillator safety margin (DSM) test [21]. In this method, a single or two VF inductions may be enough. The device is usually programmed to a value that is expected to restore sinus rhythm following induction. This value depends on the operator preference. It is usually an average value that is at least 10 J below the maximum output of the device [22]. If it is suc‐ cessful, then this value should at least be equal to the DFT value. If the shock fails, then step up approach has to be used to find the threshold.


**Table 1.** Incidence of high DFT

rhythm and not during VF. Using this approach there is a need for more number of shocks,

The threshold to terminate ventricular fibrillation with ICD's is usually in the 5 to 30 J range. It was the ability to reduce the energy requirements by 10 folds as compared to external de‐ fibrillator that made the ICD a reality [8]. Otherwise the size of the ICD would have to be much bigger to store the needed energy for defibrillation. Although the threshold is ex‐ pressed in relation to the energy discharged by the ICD, in reality it is the voltage and its duration that is the critical factor in defibrillation [9-10]. Duration has a relatively narrow range to be effective (in the range of few milliseconds). To achieve this precise phase dura‐ tion of defibrillation, the capacitor discharge is truncated in either a tilt based formula which truncates the discharge after a certain percentage of decay in the voltage has been reached, or more simply in a time based manner after a certain time has elapsed. Voltage is usually in the hundreds of volts range. If voltage is too low it may induce rather than terminate fibril‐ lation as explained earlier. High voltage (above 1000 Volts) is also not without its risks, as it may result in stunning of the myocardium and subsequent electromechanical dissociation [11-12]. The voltage wave form can be manipulated to make defibrillation more effective and therefore require less energy. Biphasic wave, which is the standard now in ICD's, has reversal of the initial polarity. The initial wave results in charging of the cell membrane as a result of the voltage gradient. The reversal which is termed "burping" is theorized to absorb the initial energy and therefore avoid proarrhythmia [11-12]. The biphasic wave form can be manipulated by changing the initial voltage, and by changing the duration and the ratio of its waves. Different manufactures use different formulas in their devices, and some allow

changing of the parameters by the electrophysiologists in case of high DFT.

careful monitoring of vital signs and saturation level [14].

Before doing DFT testing, consent should be taken from the patient explaining the risk and benefit of the procedure. Vital signs should be stable and basic lab results such as electro‐ lytes should be within normal range. There should be no contraindication to performing the test such as severe aortic stenosis or intracavitary thrombus. An external defibrillator should be placed ready next to the patient, preferably with defibrillator patches attached to the pa‐ tient. As the shock is painful, adequate sedation or short anesthesia should be given with

After the device is implanted good lead position should be verified by X-ray. The lead is tested to ensure adequate sensing and pacing thresholds and normal impedance values.

Prior to VF induction, the device is activated and programmed with the amount of energy to be delivered. Ventricular fibrillation is usually induced via the device. There are several methods of VF induction such as programmed ventricular stimulation, T wave shock, fast burst pacing, or by applying low voltage direct current [15]. Following VF induction the pa‐ tient is monitored carefully until the device detects the arrhythmia and restores it back to sinus rhythm. If the device fails, external defibrillation should be immediately performed.

but less number of times that VF are induced.

122 Cardiac Defibrillation

**3. Performing DFT testing**

High DFT, defined in most studies as a threshold of < 10 J below the maximum output of the device, is estimated to occur in about 5% of ICD implants (range 1.4 to 18%) (Tables 1) [23-33]. Although the exact value of DFT cannot be predicted in an individual patient prior to testing, there are some clinical parameters associated with increased thresholds (Table 2) [27-29,32-35].


**Adjustment to improve DFT Comment**

Medications [37-41] Particularly amiodarone has been shown to increase thresholds.

Lead Polarity [43-44] The RV lead is the anode (positive) vector. It may be changed to cathode

be changed electronically. Wave form [41,46] Change of Tilt and phase duration of shocks is available in some devices and may be optimized individually.

Lead repositioning [47-48] Apical position has lower DFT when compared to a proximal position.

introduced to lower thresholds

Changing or stopping a medication associated with high threshold may help the problem [37]. Amiodarone has been particularly quoted in the literature as causing high thresholds [38]. Other possible medications include lidocaine and verapamil. On the other hand, medi‐ cations that do not affect or potentially reduce DFT include sotalol, dofetilide, beta-blocker

There are some programmable parameters in the ICD that can affect DFT. These include po‐ larity of the lead, the vector of defibrillation, and the tilt and duration of the shock wave [41-42]. The lead is configured with an anodal (positive) distal coil. This configuration re‐ sults in an average reduction of 15% in DFT as compared to a cathodal right ventricular (RV) coil [43]. Reversing it to cathode results in the energy propagating away from the lead in‐ stead of "collapsing" towards it. This is theorized to increase the arrhythmia potential. How‐ ever, changing polarity has been shown to decrease DFT in some of the patients and this

A dual-coil, active pectoral lead system is the most commonly used configuration. A proxi‐ mal coil placed in the superior vena cava (SVC) area has been found to decrease DFT as compared to a single coil system [41,45]. This effect is particularly effective when the single coil resistance is high (above 58 ohm), while the effect on the threshold is mixed with low single coil resistance. Control of proximal coil can be done electronically in a dual coil lead. Addition of an SVC coil might be considered in patients with single coil and high resistance.

dofetilide.

(negative).

Vector of defibrillation [41,45] Adding an SVC coil is most effective when a single coil has high

Medications that potentially decrease thresholds include sotalol and

Defibrillator Threshold Testing http://dx.doi.org/10.5772/52594 125

resistance of > 58 ohm. If dual coil system is implanted, the vector can

Subcutaneous array, coronary sinus and azygous vein leads could be

Septal and RVOT positions may have lower thresholds

*Non Invasive*

*Invasive*

of the shock [49-51].

Addition of extra leads to change the vector

Upgrading to higher output device

**Table 4.** Approaches to improve DFT

and dronedarone [37-40].

configuration can therefore be attempted [44].

**Table 2.** Clinical factors associated with high DFT 's

DFT testing is usually performed introperatively at the time of implant before the pocket is closed to allow intervention in case of high thresholds. Sometimes it is done at the time of discharge or at a later time when the lead has assumed a stable position [28,36].

#### **4. Management of high DFT**

If a patient is found to have elevated thresholds, the initial step is to verify that this is not caused by a reversible problem related to the implant procedure itself (table 3). If no reversi‐ ble cause is found, then there are several options available. These are classified into non-in‐ vasive and invasive methods (table 4).


**Table 3.** Reversible causes of high DFT


**Table 4.** Approaches to improve DFT

Young age

124 Cardiac Defibrillation

Low ejection fraction

Large body size

**4. Management of high DFT**

vasive and invasive methods (table 4).

Hypotension Pneumothorax Pericardial effusion Large pleural effusion Pulmonary edema

Acidosis

**Table 3.** Reversible causes of high DFT

Medications Ischemia

Electrolyte imbalance

Prolonged procedure Lead dislodgment

Sedation related such as aspiration and hypoxia

Prolonged QRS duration

**Table 2.** Clinical factors associated with high DFT 's

Hypertrophic cardiomyopathy Non coronary artery disease

Medications (specially amiodarone) Larger and small left ventricular sizes

DFT testing is usually performed introperatively at the time of implant before the pocket is closed to allow intervention in case of high thresholds. Sometimes it is done at the time of

If a patient is found to have elevated thresholds, the initial step is to verify that this is not caused by a reversible problem related to the implant procedure itself (table 3). If no reversi‐ ble cause is found, then there are several options available. These are classified into non-in‐

discharge or at a later time when the lead has assumed a stable position [28,36].

Changing or stopping a medication associated with high threshold may help the problem [37]. Amiodarone has been particularly quoted in the literature as causing high thresholds [38]. Other possible medications include lidocaine and verapamil. On the other hand, medi‐ cations that do not affect or potentially reduce DFT include sotalol, dofetilide, beta-blocker and dronedarone [37-40].

There are some programmable parameters in the ICD that can affect DFT. These include po‐ larity of the lead, the vector of defibrillation, and the tilt and duration of the shock wave [41-42]. The lead is configured with an anodal (positive) distal coil. This configuration re‐ sults in an average reduction of 15% in DFT as compared to a cathodal right ventricular (RV) coil [43]. Reversing it to cathode results in the energy propagating away from the lead in‐ stead of "collapsing" towards it. This is theorized to increase the arrhythmia potential. How‐ ever, changing polarity has been shown to decrease DFT in some of the patients and this configuration can therefore be attempted [44].

A dual-coil, active pectoral lead system is the most commonly used configuration. A proxi‐ mal coil placed in the superior vena cava (SVC) area has been found to decrease DFT as compared to a single coil system [41,45]. This effect is particularly effective when the single coil resistance is high (above 58 ohm), while the effect on the threshold is mixed with low single coil resistance. Control of proximal coil can be done electronically in a dual coil lead. Addition of an SVC coil might be considered in patients with single coil and high resistance. The proximal coil location should be in the high SVC and brachiocephalic area rather than the low SVC and atrial area as the later is associated with higher DFT value [45].

DFT testing. Several studies gradually emerged that questioned the need to find DFT (ta‐ ble 5). This lack of benefit of DFT testing shown in several studies may be explained by

Defibrillator Threshold Testing http://dx.doi.org/10.5772/52594 127

**•** The comparison of the mortality in patients who had DFT testing versus those who did not have a test may be a biased by excluding unstable patients from DFT testing and in‐

**•** The comparison should include the morbidity and mortality associated with the test itself and also the problems related to the intervention to reduce DFT. Even simple measures such as changing a medication and reprogramming the ICD could have an impact on mortality, not to mention possible complications associated with invasive interventions. The shock itself done during the test may have an impact on patients with established car‐ diac disease. Defibrillation has been shown to increase troponin level [62]. Any shock,

**•** DFT does not predict future successful defibrillation in a reliable manner [18]. This may be related to the probabilistic nature of the test. It has also been shown that DFT change acutely and chronically [64-65]. This could result in the improvement of high DFT, but may also result in a patient with normal DFT developing high thresholds with time. It is estimated that about 29% of deaths in ICD recipients are still due to arrhythmias that

**•** Ventricular fibrillation induced in the hospital is not the same as the real world arrhyth‐ mia. Induced VF tends to be more organized than spontaneous VF [67]. In the clinical set‐ ting, many patients have ventricular tachycardia rather than VF or even do not have any arrhythmia at all during the lifetime of the implant [2,68-69]. For these patients DFT test

It is therefore important to have to prospective randomized study to give us a clear an‐ swer. One prospective, but not randomized study (SAFE-ICD) showed no benefit of DFT testing [60]. The result of an ongoing study (SIMPLE trial) may give a more clear direc‐

The approach to DFT testing has changed over time. A recent study in 111 Italian centers over the period 2007 to 2010 involving 2,082 patients documented the trend change [71]. It reported DFT testing to be performed in 38% of patients with the incidence declining annu‐ ally from 36% in 2007 to 28% in 2010. In 13% of centers, the test was performed routinely, and in 38% it was not performed at all. The reasons for not performing DFT testing in this survey were the policy of the center in 44%, a primary indication for the implant in 31% and doing a device replacement in 15%. Not doing DFT testing can certainly make the ICD im‐ plant simpler. The simplification is not just related to the procedure itself, but starts with the initial step of taking the consent from the patient. It is not a simple task to explain the risk to the patient in a lay term without confusing him. A physician has to explain that after the surgery has finished successfully, there will be a need to stop the heart; and that there is a chance, even though very small, that he may have a problem like stroke or that we may not

even when inappropriate, has been associated with increased mortality [63].

several factors:

cluding them in the non tested group.

could not be terminated by the ICD [66].

be able to restore his heart to beat back again.

tion once finished [70].

may be misleading or may not have any relevance at all.

The phase duration of defibrillation is critical in achieving sinus rhythm [9-10]. The optimal phase duration is not exactly known and it can be optimized in some devices for individual patients with high DFT's [46].

Changing a nominal parameter should not be taken lightly, as these are the ones tested and proven with clinical research. Any adjustment made to the settings should be verified by re‐ peated induction and the reassurance of a successful defibrillation.

Several invasive choices that reduce DFT are available. Changing the RV lead location may reduce DFT. The standard RV position is the RV apex. This has the advantage of a stable position and good threshold. Alternative lead positions that have good thresholds are the right ventricular outflow tract (RVOT) and the septum. An active fixation system should be used in these areas. A right free wall position has the highest DFT [47-48]. Changing the shock vector may lower DFT. This can be achieved by incorporating subcutaneous array or an additional lead in the azygous vein or the coronary sinus [49-51]. Upgrading to higher output devices may be useful in patients with borderline elevated thresholds.
