**1. Introduction**

The ocular surface is a functional unit mainly formed by the conjunctival and corneal epi‐ thelium (structural component), and tear film (soluble component). Microorganisms and environmental allergens can interact with the tear film, reach the structural component and generate an immune response against them. Understanding the cellular and soluble mediators that are involved in these inflammatory responses not only helps in under‐ standing the mechanisms of current treatments, but also is needed to identification and development of new therapeutics targets. The aim of this review was to investigate the novel and developing therapies, with special emphasis in immunomodulatory drugs/ molecules that could have some clinical indication in the treatment of infectious and aller‐ gic conjunctivitis in few years.
