**Clinical Features**

**Chapter 5**

**Clinical Manifestations of Sarcoidosis**

Luis Jara-Palomares, Candela Caballero-Eraso,

Additional information is available at the end of the chapter

Sarcoidosis is a systemic granulomatous disease of unknown etiology that is characterized from the point of view of pathology of the presence of noncaseating granulomas in affected organs. Typically affects young adults and is often present initially with one or more of the following conditions: 1) bilateral hilar lymphadenopathy, 2) pulmonary reticular pattern, 3)

In this chapter we are going to review and update the clinical features and sign of

Patients with pulmonary sarcoidosis may have impaired upper and/or lower airway, and could be impossible or difficult to detect with routine imaging, but are recognized by alterna‐ tive diagnostic tests (eg, bronchoscopy) [1]. Endobronchial disease exists in approximately 40% of patients with stage I disease, and approximately 70% of patients with stage II or III. Airway stenosis clinically significant is rare but can be unwieldy when severe [2, 3]. Table 1 summarize

In the fibrotic stage of the disease can be observed thinning of the mucosa, pallor, and scarring

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© 2013 Jara-Palomares et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2013 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,

can lead to a decrease in the light of the airways and the stenosis [4-6].

Cesar Gutiérrez, Alvaro Donate and

Involvement of the skin, joints and / or eyes.

Jose Antonio Rodríguez-Portal

http://dx.doi.org/10.5772/55556

**1. Introduction**

sarcoidosis.

**2. Airway involvement**

the airway involvement in sarcoidosis.

### **Chapter 5**
