**1. Introduction**

Retinoblastoma is a highly malignant tumor of the eye that manifests most often in the first 3 years of life. Early detection is essential to preserve visual function, and decrease mortality from retinoblastoma. Late diagnosis globally results in up to 70% mortality; where optimal therapy is accessible, more than 95% of children are cured.

Telemedicine has many possible applications in ophthalmology, from community screening to the provision of expertise in areas where it is otherwise not available. Broad-based appli‐ cations of telemedicine could greatly enhance screening efforts for potentially blinding conditions such as diabetic retinopathy, macular degeneration, glaucoma, retinopathy of prematurity as well as retinoblastoma. In this chapter we discuss specifically the application of telemedicine in management of retinoblastoma. Telemedicine can help to bring subspecialty expertise to small or rural communities, as well as to the developing world.
