**13. Conclusion**

The functional nature of the TM inevitably results in exposure of this tissue to a highly dynamic environment. Examining the functional roles of single genes have provided invaluable insight into how specific genes contribute to normal TM cell function and how these TM cells are able to respond to specific stresses. However, the recent analyses of global gene expression profiles have indicated that an extensive number of genes are involved in mediating the TM cell stress response. We are beginning to piece together how these singles genes function as part of a 'network' of genes. Individual components of this network of genes are potential therapeutic targets for promoting cell survival and maintaining TM cell function. However, future research needs to examine how these genes interact with each other and the environment in a more physiologically relevant context; as part of a TM stress-response network. Understanding the network of genes that are involved in executing the adaptive response is complicated, but essential to developing effective treatments for anterior segment malformations and glaucoma.
