**12. Data analysis**

**10.2. Category 2**

more between both eyes

260 Glaucoma - Basic and Clinical Aspects

**10.3. Glaucoma suspect**

diagnosed with suspected glaucoma

**11. SPAC examination**

When the visual field test is not reliable or available, the cup-to-disc ratio of the optic nerve head is 0.9 or more, or the rim width at the superior portion (11-1 h) or the inferior portion (5-7 h) is 0.05 or less of the disc diameter, or the difference of the vertical cup-to-disc ratio is 0.3 or

When the cup-to-disc ratio of the optic nerve head is 0.7 or more portion (5-7 h) is 0.1 or less but more than 0.05 of the disc diameter but less than 0.9, or the rim width at the superior portion (11-1h) or the inferior, or the difference of the vertical cup-to-disc ratio is 0.2 or more but less than 0.3 between both eyes, or the nerve fiber layer defect is found, and the visual field test is not reliable or available or does not show hemi-field based compatible defect, the eye is

All subjects underwent examination with SPAC. Paramedical staff correctively measured the ACD of 658 subjects (703 eyes of 354 men, 607 eyes of 304 women). SPAC examines the region from the optical axis to the temporal limbus in approximately 0.66 s, taking 21 consecutive slitlamp images at 0.4-mm intervals. The camera-captured cross-sectional slit-lamp images are immediately subjected to analysis, and the radius of curvature, the corneal thickness, and ACD values are displayed. The SPAC yields numeric and categorical grades that are calculated by comparison with the ACD values derived from a sample of Japanese subjects [18]. In our study, the range of ACD values of the patients was divided into 12 groups, each representing an equal increment in the ACD. Group 12 consisted of eyes with the deepest mean ACD values, whereas

Based on the data provided by SPAC, the following parameters were determined: distri‐ bution of ACD from the central and the peripheral region, distribution of the grades of ACD, and frequency of suspected (S) or possible (P) angle-closure eyes. The high risk of angle closure group includes eyes judged as S or P, or grade ≤5 by SPAC. These eyes were eligible for the definitive examination, The SPAC automatically calculates central ACD along the visual axis. Peripheral ACD means anterior chamber depth at 5.6 mm

Of 1420 eyes of the 710 participants of the glaucoma screening study, reliable SPAC re‐ sults were analyzed in 1310 eyes of 658 participants (Table 3). 104 eyes of fifty two par‐ ticipants were omitted from the study. The main reason for exclusion were that SPAC measurements could not be completed at the screening sites for various reasons, such as subjects' ocular or physical problems. 100 eyes were unable to fixate the fixation lamp due to poor visual acuity, and 2 subjects (4 eyes) were unable to keep their faces on the chin rest during measurement. Between the included and excluded subjects, the male/

eyes with the shallowest mean ACD values were allocated to group 1.

apart from the anterior pole of the lens (Fig. 3).

female ratio was not statistically different (P = 0.44, χ2 test).

Descriptive statistical analysis for the determination of mean±standard deviation (SD) for continuous values was performed with SPBS software (Nankodo Publisher, Statistical Package for the Biosciences version 9.51, Tokyo, Japan). Data from both eyes of each individual were used, as it was more efficient and informative than data for single eyes. Comparisons of the different SPAC parameters between males and females or among each age group were analyzed with paired and unpaired t tests. Pearson correlation coefficients were calculated to assess the strength of the correlations between SPAC parameters and potential confounders. For all analyses, P<0.05 was considered statistically significant.
