**Meet the editors**

Jean Elwing, M.D. completed her undergraduate and medical education at Saint Louis University in 1997. She remained at Saint Louis University and completed a combined residency in Internal Medicine and Pediatrics in 2001. She received her fellowship training in Pulmonary and Critical Care Medicine at the University of Cincinnati. In January 2007 she joined the faculty in

the College of Medicine at the University of Cincinnati. She is currently an Associate Professor of Medicine and the Director of the Pulmonary Hypertension Program in the Division of Pulmonary, Critical Care and Sleep Medicine. Her clinical and research focus is pulmonary vascular disease and pulmonary hypertension.

Ralph Panos is Associate Chief of Staff for Research and Development and Medical Director of the VISN 10 TeleICU program at the Cincinnati Veterans Administration Medical Center and Professor of Medicine at the University of Cincinnati College of Medicine. He graduated from the Brown University Program in Medicine, completed his medicine residency and chief residency

at the University of Maryland, Baltimore, MD, and his pulmonary fellowship training at the University of Colorado and National Jewish Hospital, Denver, CO. His major research interests are interstitial lung disease and chronic obstructive pulmonary disease.

Contents

**Preface VII**

Petrovsky

**and/or Hypoxia 21**

Rajamma Mathew

**Hypertension 75**

and Kazuo Maruyama

Chapter 1 **Pulmonary Arterial Hypertension: An Overview 1** Dr Saleem Sharieff MBBS, FCPS, FRCPC

Chapter 2 **Pulmonary Hypertension in Chronic Lung Diseases**

Chapter 3 **Pathogenesis of Pulmonary Hypertension 47**

Chapter 5 **Angiogenesis and Pulmonary Hypertension 103** Aureliano Hernández and Rafael A. Areiza

Jean M. Elwing and Ralph J. Panos

Mehdi Badidi and M'Barek Nazi

**Hypertension 169**

Chapter 6 **Acute Thromboembolic Pulmonary Hypertension 117**

Chapter 7 **Chronic Thromboembolic Pulmonary Hypertension 143**

Chapter 8 **Assessment of Diagnostic Testing to Guide the Surgical**

**Management of Chronic Thromboembolic Pulmonary**

Juan C Grignola, María José Ruiz-Cano, Juan Pablo Salisbury, Gabriela Pascal, Pablo Curbelo and Pilar Escribano-Subías

Dimitar Sajkov, Bliegh Mupunga, Jeffrey J. Bowden and Nikolai

Junko Maruyama, Ayumu Yokochi, Erquan Zhang, Hirofumi Sawada

Chapter 4 **Nitric Oxide in Pathophysiology and Treatment of Pulmonary**
