**20. Glyceollins**

Glyceollins produced from daidzein in soybeans cultured with fungi exert antifungal and can‐ cer preventive actions [23]. Isoflavones and metabolites serve as a mixed agonist/antagonist for estrogen. Glyceollins suppress some cancer cells via anti-estrogenic activity. Estrogenic effects of glyceollins have been demonstrated using E-screen assay and pS2 expression. Glyceollins ex‐ hibited higher affinity for estrogen receptor beta than estrogen receptor alpha. After *Aspergillus sojae* infection glyceollins were more efficiently produced de novo in minced soybean than in half-sliced soybean. Hence glyceollins may be useful for preventing or alleviating postmeno‐ pausal complications due to potent estrogenic activity, and their production could be varied de‐ pending upon processing prior to fungal inoculation [23].
