**17. Bowman-Birk (BBI) isoinhibitors**

Two major soybean isoinhibitors, IBB1 and IBBD2, were found in soybean. IBB1 inhibit‐ ed both trypsin and chymotrypsin while IBBD2 was trypsin-specific. The median inhibi‐ tory concentration values of IBB1 and IBBD2 on HT29 colon cancer cell growth were not significantly different (39.9+/-2.3 and 48.3+/-3.5 M, respectively). The distribution pattern of HT29 colon cancer cells was affected by BBI: cells remained in the G0-G1 phase of the cell cycle [20].
