**List of abbreviations:**

**ABC** ATP-binding cassette; **AGM** aorta-gonad-mesonephros; **ALM** anterior lateral meso‐ derm; **ATP** adenosine triphosphate; **BFU-E** burst-forming unit-erythrocyte; **bZIP** basic leu‐ cine zipper domain; **CCM** cell-conditioned medium; **C/EBPs** CCAAT/enhancer binding proteins; **CFU** colony forming unit; **CFU-G** colony-forming unit-granulocyte; **CFU-GEMM** colony-forming unit granulocyte/erythrocyte/macrophage/megakaryocyte; **CFU-GM** colo‐ ny-forming unit-granulocyte/macrophage; **CFU-M** colony-forming unit-macrophage; **CFU-Meg** colony-forming unit-megakaryocyte; **CFU-S** colony-forming unit-spleen; **CHT** caudal hematopoietic tissue; **CLP** common lymphoid progenitor; **CMP** common myeloid progeni‐ tor; **ConA** concanavalin A; **CRH** cytokine receptor homology; **CSFs** colony-stimulating fac‐ tors; **CSF-1** colony-stimulating factor 1; **CSF-1R** colony-stimulating factor-1 receptor; **DCs** dendritic cells; **EGR/egr** early growth response; **EPO** erythropoietin; **GCSF** granulocyte col‐ ony-stimulating factor; **GFI1** growth factor independence 1; **GM-CSF** granulocyte/macro‐ phage colony-stimulating factor; **GM-CSFR** granulocyte/macrophage colony-stimulating factor receptor; **GM-CSFRα** granulocyte/macrophage colony-stimulating factor receptor al‐ pha chain; **GMP** granulocyte/macrophage progenitor; **HPCs** hematopoietic progenitor cells; **hpf** hours post fertilization; **HSCs** hematopoietic stem cells; **IL** interleukin; **IL-3Rα** interleu‐ kin-3 receptor alpha; **IRF** interferon response factor; **JAK** Janus family of protein tyrosine kinases; **Ks/Ka** ratio of synonymous to asynonymous nucleotide substitutions; **LMPPs** lym‐ phoid-myeloid primed multipotent progenitors; **LPS** lipopolysaccharide; **LT-HSCs** longterm hematopoietic stem cells; **MCSF** macrophage colony-stimulating factor; **mCSF-1R** membrane-bound colony-stimulating factor-1 receptor; **MEP** megakaryocyte/erythroid pro‐ genitor; **MMP** matrix metalloprotease; **mpo** myeloperoxidase; **MPPs** multipotent progeni‐ tors; **mpx** myeloid-specific peroxidase; **mRNA** messenger ribonucleic acid; **mSCF** membrane-bound stem cell factor; **multi-CSF** multi-lineage colony-stimulating factor; **NFkB** nuclear factor kappa B; **NK** natural killer; **PBI** posterior blood island; **PBL** peripheral blood leukocytes; **PDGFR** platelet-derived growth factor receptor; **PGCs** primordial germ cells; **PKM** primary kidney macrophages; **PI3K** phosphatidylinositol-3-kinase; **PLCγ** phos‐ pholipase Cγ; **PLM** posterior lateral mesoderm; **PMA** phorbol esters; **Poly I:C** polyinosin‐ ic:polycytidylic; **RasGRP1** Ras guanine nucleotide releasing protein 1; **RBI** rostral blood island; **SCF** stem cell factor; **sCSF-1R** soluble colony-stimulating factor-1 receptor; **SOCS** suppressor of cytokine signaling; **sSCF** solube stem cell factor; **STATs** signal transducers and activators of transcription; **ST-HSCs** short-term hematopoietic stem cells; **TFs** transcrip‐ tion factors; **UTR** untranslated region;

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