Contents



Chapter 6 **Regulation of Cell Fate in the Brain by GSK3 153** Adam R. Cole

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Preface

During the last decades, numerous studies about stem cells and regenerative medicine high‐ lighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understand‐

The main objective of this book is to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development. Indeed, in this book, we deeply described TGF-beta signaling, Wnt Signal‐ ing, neurotrophin and NF-κ-B signaling and their implication in neuronal fate decision.

The second objective of this book is to understand how those pathways are altered in pathologi‐ cal conditions. We consequently analyzed those pathways in several pathological conditions. Finally the third objective of this book is to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions, based on new molecular biology findings. Several sources of stem cells and their potential benefits

Finally, I would like to conclude this preface by expressing my deepest gratitude to all au‐

**Sabine Wislet-Gendebien, PhD**

University of Liège, Belgium

GIGA Neurosciences

ings of stem cell biolology leading to specific cell fate decision.

were described in the last part of this book.

thors who contributed to the elaboration of this book.

Chapter 13 **Neural Fate of Mesenchymal Stem Cells and Neural Crest Stem Cells: Which Ways to Get Neurons for Cell Therapy Purpose? 327** Virginie Neirinckx, Cécile Coste, Bernard Rogister and Sabine Wislet-Gendebien
