**Author details**

Harleen S. Basrai, Kimberly J. Christie and Ann M. Turnley\*

\*Address all correspondence to: turnley@unimelb.edu.au

Centre for Neuroscience Research, Department of Anatomy and Neuroscience, The Univer‐ sity of Melbourne, Victoria, Australia

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**Chapter 11**

**Neural Stem/Progenitor Cells for**

Additional information is available at the end of the chapter

Central nervous system (CNS) repair and regeneration following traumatic injury or disease pathology is a widely studied and widely debated field. This book chapter will outline the pathology of spinal cord injury (SCI) with particular focus on how it lends itself to cell-based intervention. Next, we will outline the different populations of cells proposed for SCI treat‐ ment, including neural stem/progenitor cells (NSPC), and methods of generating clinically relevant NSPCs from adult tissue, embryonic stem (ES) cells and induce pluripotent stem (iPS) sources. Lastly, we will examine the use of NSPCs in SCI models with a specific focus on how the environment affects the transplanted population and how the transplanted cells modulate

Spinal cord injury (SCI) is a devastating event that significantly affects the morbidity and quality of life in adults (Average age of patients at the time of injury is 38.0 years old). [1] The prevalence of traumatic SCI worldwide is approximately 750 per million with an increasing annual incidence. [2] In order to be able to develop effective treatments for SCI, it is necessary to have a detailed understanding of the pathophysiological events that happen during SCI in the body and how they interact with each other to cause the functional deficits seen in patients. These events have complicated roles post-SCI. For example, the inflammatory response and reactive astrogliosis that are seen post-SCI have damaging *and* neuroprotective and –restora‐

> © 2013 Salewski et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2013 Salewski et al.; licensee InTech. This is a paper distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**Spinal Cord Regeneration**

Ryan Salewski, Hamideh Emrani and

Michael G. Fehlings

**1. Introduction**

the spinal cord niche.

tive effects. [3]

**2. Pathology of spinal cord injury**

http://dx.doi.org/10.5772/55054

**Chapter 11**
