*4.2.1. Oxidative stress (ROS; NO; GSH).*

Keratin is a cytoskeleton protein which have some abilities to maintain the cell shape, Guo-Zhong Tao group found that keratin can modulate the shape of mitochondria and contribute to hepatocyte predisposition to apoptosis and oxidative injury [42].Depletion the mitochondria GSH in the human B lymphoma cell line by treatment with L-buthionine sulfoximine can induce caspase-3 activation and apoptosis, and indicating that GSH may be the potential early activator of apoptotic signal [43]. ROS is a type of toxic compound and usually detoxified by cells GSH, when the oxidative stress occur, the ROS detoxify will be failed, and ROS will participate in apoptosis through redox-sensitive death pathway.
