**6. References**


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18 Apoptosis and Medicine

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**Acknowledgement** 

This work was supported by National Natural Science Foundation of China (81101220); Tianjin Municipal Science and Technology Commission (12JCQNJC08100); Key (Key grant) Project of Chinese Ministry of Education (210010). In the end, I would like to extend my sincere gratitude to the Dr Ruan Haihua for her instructive advice and useful suggestions on

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**Section 2** 

**Apoptosis and Physiology** 


**Apoptosis and Physiology** 

22 Apoptosis and Medicine

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**Chapter 2** 

© 2012 Kwon et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2012 Kwon et al., licensee InTech. This is a paper distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**Osteocyte Apoptosis-Induced** 

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/50301

**1. Introduction** 

human femur.

**1.1. Cells activity in bone** 

and mechanical stimuli (Klein-Nulend et al., 2005).

**Bone Resorption in Mechanical** 

**Remodeling Simulation – Computational** 

Ji Yean Kwon, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka

Biomechanical function is one of primal concern in musculo-skeletal system supporting our body as a whole. The functional adaptation of bone to the mechanical environment has been most interesting topic in bone mechanics. We have proposed the generalized model of bone remodeling simulation considering osteocyte apoptosis and targeted remodeling. These are important factors of bone metabolism under physiological and pathological conditions. This remodeling model has the capability to speculate the changes in the trabecular bone structures under various loading conditions. In this chapter, we describe how the osteocyte apoptosis-induced bone resorption has importance in computer simulations for disusemeditated trabecular bone remodeling resulting in the osteoporotic bone structure in the

Bone tissue is the component of the skeletal system supporting human body. Bone structure is continuously renewed by remodeling, that is, the alternately-repeated events of local bone resorption and formation. Three mature cell types of osteoblasts, osteoclasts and osteocytes play crucial roles in bone remodeling process. Bone metabolism is regulated by bone cells which respond to various environmental signals coming from chemical, magnetic, electrical

Osteoblast are bone forming cells that synthesize and secrete bone matrix, participate in the calcification and formation of bone, and regulate the flux of calcium and phosphate in and

**Model for Trabecular Bone Structure** 
