**Meet the editor**

Doctor Tobias M. Ntuli holds a doctorate in Cell Biology from the Department of Biological and Conservation Sciences at the University of KwaZulu-Natal in Durban in South Africa. Doctor Ntuli has carried out numerous postdoctoral research on various universities such as the University of Cape Town in South Africa, Tropical Botanical Gardens in Menglun, Mengla, Yunnan

in China, School of Molecular and Cell Biology at the University of the Witwatersrand in South Africa, the Indigenous Knowledge Systems (of Health) Research Unit at the South African Medical Research Council in Cape Town and at the University of South Africa based in the Structural Biology Laboratory of the Biosciences Unit of the Council of Scientific and Industrial Research in Pretoria. Doctor Ntuli's current research interests include biochemistry, molecular biology and physiology of the possible role of apoptosis in plant stress tolerance and sensitivity.

Contents

**Preface IX** 

**Section 1 Introduction to Apoptosis 1** 

Zhao Hongmei

Chapter 1 **Extrinsic and Intrinsic Apoptosis Signal Pathway Review 3** 

**Section 2 Apoptosis and Physiology 23** 

**Section 3 Apoptosis and Pathology 47** 

Yasuhiko Hirabayashi

and Isabel Martínez-Lacaci

Chapter 5 **Apoptosis as a Therapeutic Target** 

**in Cancer and Cancer Stem Cells:** 

Chapter 2 **Osteocyte Apoptosis-Induced Bone Resorption in Mechanical Remodeling Simulation –** 

Takeshi Matsumoto and Masao Tanaka

Chapter 4 **Cell Death and Cancer, Novel Therapeutic Strategies 67**  Silvina Grasso, M. Piedad Menéndez-Gutiérrez,

> Lourdes Rocamora-Reverte, Ángeles Gómez-Martínez, Pilar García-Morales, José A. Ferragut, Miguel Saceda

**Novel Strategies and Futures Perspectives 111** 

Elena López-Ruiz, Macarena Perán, Manuel Picón,

Ji Yean Kwon, Hisashi Naito,

Chapter 3 **Cell Death and Anti-DNA Antibodies 49** 

**Computational Model for Trabecular Bone Structure 25** 

Estefanía Carrasco-García, Leticia Mayor-López, Elena Tristante,

María A. García, Esther Carrasco, Alberto Ramírez, Gema Jiménez,

Joaquín Campos, Houria Boulaiz and Juan Antonio Marchal
