**Acknowledgement**

This work was supported by National Natural Science Foundation of China (81101220); Tianjin Municipal Science and Technology Commission (12JCQNJC08100); Key (Key grant) Project of Chinese Ministry of Education (210010). In the end, I would like to extend my sincere gratitude to the Dr Ruan Haihua for her instructive advice and useful suggestions on this thesis.

Extrinsic and Intrinsic Apoptosis Signal Pathway Review 19

[14] Jennifer R. Hom, Jennifer S. Gewandter, Limor Michael, et al. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial

[15] Van Laar VS, Berman SB. Mitochondrial dynamics in Parkinson's disease. Exp Neurol.

[16] Ardehali R, Inlay MA, Ali SR, et al. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum

[17] Luo H, Zhang Y, Zhang Z, et al. The protection of MSCs from apoptosis in nerve regeneration by TGFβ1 through reducing inflammation and promoting VEGF-

[18] Bergmann A, Steller H.Apoptosis, stem cells, and tissue regeneration. Sci Signal. 2010,

[19] Susanne Herbst, Ulrich E.Schaibel, Bianca E.Schneider. Interferon Gamma Activated Macrophage by Nitric Oxide Induced Apoptosis. PLoS one, 2011, 6(5):1-8.e19105. [20] Lebman D, Edmiston J. The Role of TGF-beta in growth, differentiation, and maturation

[21] Singhal J, Dalasanur Nagaprashantha L, Vitsyayan R. et al. Didymin Induced Apoptosis by Inhibiting N-Myc and Up-regulating RKIP in Neuroblastoma. Cancer Prev

[22] Hung JY, Hsu YL, Ko YC.et al. Didymin, a dietary flavonoid glycoside from citrus fruits, induced Fas-mediated apoptotic pathway in human non-small-cell lung cancer

[23] Inoue H, Waiwut P, Saiki I,et al. Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5. Int J

[24] Zhou J, Lu GD, Ong CS, et al. Andrographolide sensitizes cancer cells to TRAILinduced apoptosis via p53-mediated death receptor 4 up-regulation. Mol Cancer Ther.

[25] Prasad S, Yadav VR, Kannappan R, et al. Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. J Biol Chem. 2011,

[26] Plissonnier ML, Fauconnet S, Bittard H. The Antidiabetic Drug Ciglitazone Induces High Grade Bladder Cancer Cells Apoptosis through the Up-Regulation of TRAIL.

[27] Wendrenmaire M, Bardou M, Peyronel C. Effects of leptin on lipopolysaccharideinduced myometrial apoptosis in an in vitro human model of chorioamnionitis. Am J

[28] Susanne Herbst, Ulrich E.Schaibel, Bianca E.Schneider. Interferon Gamma Activated Macrophage by Nitric Oxide Induced Apoptosis. PLoS one, 2011, 6(5):1-8.e19105.

fission and apoptosis. Journal of cellular physiology, 2007, 212(2):498-508.

factors. Proc Natl Acad Sci U S A. 2011, 22; 108(8):3282-3287.

dependent angiogenesis. Biomaterials.2012,33(17):4277-4287.

of B lymphocytes. Microbes Infect. 1999, 1(15):1297-1304.

cells in vitro and in vivo. Lung cancer. 2010, 63(3):366-374.

2009, 218(2):247-256.

3(145):1-16.

Res(Phila) 2012,5(3):473-483.

Oncol.2012, 40(4: 1058-1065.

PLoS One. 2011, 6(12):1-12.

Obstet Gynecol. 2011, 205(4):1-363.

2008, 7(7):2170-2180.

286(7):5546-5557.
