*4.2.4. Endoplasmic reticulum (ER) stress*

As the apoptogenic factor, the permeabilization of lysosomal membrane can induce apoptosis by both caspase-dependent and caspase-independent pathway [48]; Tackled with the unfolded proteins is the one of the important ER functions, cell can regulate the unfolded proteins in ER according to metabolically needed, while if numerous unfolded proteins stimulate the ER and make the ER overload stress, the cells which have lots of unfolded proteins will apoptosis[49]; Differing from the ER stress, chaperons will protect this cell death. For example, the HSP72 protein can hamper the apoptosis through down regulating the unfolded protein signal response sensor IRE1alpha. Some neurodegeneration diseases usually accompany with unfolded protein accelerated and ER stress. So it is meaningful to research the relationship between the ER stress and neurodegenration diseases, and by this way, we will well known the function of apoptosis in the some neurodegeration diseases.

The intrinsic components, which can trigger apoptosis pathway, can connect with each other by the vivo organelles. By this way, lots of materials in the cells will consisted in the network of apoptosis to feedback the vitro stimulus, This type cell death will mostly help for the body health.
