**2. Apoptosis research time line**

Cell death is essential for body homeostasis, currently years research, cell death can be classified as necrosis, apoptosis, pyroptosis. Necrosis is the first to be found, and then in the 1972 year, the apoptosis term began to be used; several years ago, pyroptosis was been known by the symbol of formation hole in cell membrane and released inflammatory factors. Apoptosis research started in the nineteen century. According to the past research, we collect and analyze the research of apoptosis and give the following summary of history and highlights about apoptosis in Table1


**Table 1.** History and highlights about apoptosis research

In 2002 year, the Nobel Prize in medicine was awarded to the Sydney Brenner, Horvitz and John E suston, according they contribute to the apoptosis research. They make a stone research work in organ development research and genetic systemic regulation programme cell death. Sydney Brenner's contribution is the construction of nematode of C.elegan model. And subsequently, suston found the cell lineage of C.elegan and found the first gene(Nuc-1) related with apoptosis. Now the C.elegan is still the classic model to research apoptosis and organ development research, Now, apoptosis has been found in the tumor development, and it has been clear that alteration of apoptotic pathways is a common feature of tumors, enabling cancer cells to survive chemotherapeutic interventions, so apoptosis signal pathway molecular become attractive targets in cancer therapy. Beside involving in the tumor development, apoptosis have been found in many other diseases, such as neurodegenerative diseases, diabetes, stroke and so on. Here, we review the fundamental apoptotic pathways and summarize many ligands that can trigger apoptosis and give some insights in the designing some drugs, plus, we also give the opinions that changes the dietary arable may be help to improve the people's healthy.
