**1. Introduction**

Biomechanical function is one of primal concern in musculo-skeletal system supporting our body as a whole. The functional adaptation of bone to the mechanical environment has been most interesting topic in bone mechanics. We have proposed the generalized model of bone remodeling simulation considering osteocyte apoptosis and targeted remodeling. These are important factors of bone metabolism under physiological and pathological conditions. This remodeling model has the capability to speculate the changes in the trabecular bone structures under various loading conditions. In this chapter, we describe how the osteocyte apoptosis-induced bone resorption has importance in computer simulations for disusemeditated trabecular bone remodeling resulting in the osteoporotic bone structure in the human femur.
