**6. Conclusions**

We have presented the systematic research on the potentiometric response of membranes modified with macrocyclic compounds containing in their structures amino groups stimulated by the undissociated phenol derivatives and membranes modified with macrocycles contain‐ ing the phenolic groups stimulated by unprotonated derivatives of aniline.

The results showed that membranes modified with calix[4]pyrrole, calix[4]phyrin and corrole derivatives are able to generate an anionic potentiometric response after stimulation with undissociated forms of phenols derivatives, whereas the membranes modified with undecyl‐ calix[4]resorcinarene derivatives are able to generate the cationic potentiometric response after stimulation with unprotonated aniline derivatives. Our experimental date indicated that in two types of membranes the movement of protons across the interface is responsible for potentiometric signal generation.

The general mechanism of the potentiometric signal generated by membranes modified with discussed host molecules stimulated by uncharged guest relies on:


In both of cases the acidity of host and basicity of guest are crucial parameters for course of processes under discussion.

**•** The sensitivity and selectivity of these processes are governed by the acidity of the target molecules studied as well as the ability of host molecules for creation of hydrogen bonds. The lipophilicity of analytes it the secondary parameter.

The described phenomena open the totally new and very promising field of analytical application of potentiometric method.
