**3.1 Metabolism of aflatoxin**

Many animal studies in order to study the metabolic fate of aflatoxins, *in vivo* and *in vitro*  studies using animal tissues have been conducted mainly on aflatoxin B1. Limited studies have also been performed on humans involving the measurement of aflatoxin B1, and its metabolites, in blood, urine, milk and isolated tissues. Metabolism has been studied in many species and under many different conditions (Dalezios et al., 1973, Yunus et al., 2010).

The metabolic fate of aflatoxins may be considered under the headings of administration, absorption, transformation (activation and detoxification), distribution and excretion.
