**7. Conclusion**

with an internal experimentally database. NaPDoS provides a rapid mechanism used to infer the generalized structures of secondary metabolites biosynthetic gene richness and diversity within a genome or environmental sample by extract and classification of ketosynthase and con‐ densation domains from PCR products, genomes, and metagenomic datasets increasing expo‐ nentially the investigations in this field of science with benefits in the field of drug discovery.

Table 1 shows a list of microorganisms isolated from different sources which produce anti‐ oxidant, antibacterial, anticoagulant, antiviral, anti-inflammatory, immune system, antidia‐

(*R*)-(-)-2-ethylhexan-1-ol Nematicidal Inhibitor against *C. elegans* and *B.*

NFAT-133 Antidiabetic induced glucose uptake in L6

*Eurotium HerbariorumE. Herbariorum* NE-4 Antioxidant Antioxidant *in vitro* [55] Water

**Fungus** 8′-O-Demethylnigerone Antituberculosis M. tuberculosis inhibition [56] Water

Closthioamide Antibiotic *Staphylococci*

*Actinomycetes* 3Ba3 Compound Antibacterial E. amylovora, P. viridiflova,

**Sponge** Batzelladine L y M Antibacterial *S. aureus* and methicillinresistant,

**Algae** Dolabelladienetriol Antiviral Inhibition of HIV-1

**Soft coral** Durumolides A-C Anti-inflammatory Modulation of LPS-activated

**Sea cucumber** Frondoside A Immune system Lysosomal activity, phagocytosis

**Table 1.** Microorganism isolated from natural sources that produce bioactive compounds

*xylophilus*

Elevation in Macrophages

Multiresistente inhibition

A. tumefaciens, B. subtilis ATCC 663, E. coli ATCC 29998 3

Antimicrobial Unespecific [54] Soil

skeletal muscle cells

Inmune system Induce Intracellular Calcium

G48 JF905613 CompoundAntimicrobial *C. albicans, S. aureus* inhibition [52] Soil

inhibition

*S. aureus* inhibition

Anticoagulant Inhibition of factor II toIIa conversion

replication

murine macrophage cell line

and ROS activation

**Bioactivity Mechanism Reference Natural**

**Source**

[48] Air

[49] Air

[50] Soil

[51] Soil

[53] Soil

[56] Water

[56] Water

[56] Water

[56] Water

[56] Water

betic and nematicidal activities, as well as their action mechanisms.

**Microorganism Bioactive**

*Brevundimonas diminuta*

*Streptomyces strain PM0324667*

*Gordonia sputi DSM*

*Micromonospora sp.* Diazepinomicin/

**Bivalve mollucs** Anticoagulant

ECO-4601

polypeptide (TGAP)

*Pasteurella haemolytica*

318 Drug Discovery

*Clostridium cellulolyticum*

*43896*

**Compounds**

A1-Derived Leukotoxin and Endotoxin

Bioactive compounds isolated from aerial, terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. To found new com‐ pounds useful to develop new pharmaceutical drugs, a good potential source and diverse bioactive chemicals is microorganism present in natural sources as air, soil and water.

Chemical compounds from natural sources are the major protagonists in chemical diversity for pharmaceutical discovery over the past century. The interesting chemicals identified as natural products are derived from the biodiversity in which the interactions between micro‐ bial entities and their environment formulate the diverse complex chemical entities within the organisms that enhance their survival and competitiveness. Hence, it is important to study inter and intraspecific interactions between microorganism in natural environments, this will make the screening for bioactive compounds in microbes easier.

Microbial interactions can influence the secretion of bioactive compound. Has been report‐ ed, various types of contacts among bacterial species and other organism. For example, these relations can be negative (parasitism, competition and predation) or positive (metabio‐ sis and symbiosis) for these microorganisms. Between interactions in microorganism we can emphasize competition. Some bacteria are reduced by different species when the environ‐ mental resources are limited; therefore they produce compounds that impress negatively in their competitors [4].

Finally, air, soil and water are the home of microorganism that compete all the time to sur‐ vive, resist changes in temperature, pressure, nutrient, carbon and nitrogen content, micro‐ organisms that are obligated to produce weapons against predators, change and mutate to scape of detection of other microbes. All this, are the reason why we can find an unimagina‐ ble number and variety of chemical that are effective to be part of a pharmaceutical drug formulation.
