**Meet the editor**

Prof. Hany A. El-Shemy received his two Ph.D. degrees in biochemistry and genetic engineering from the University of Cairo, Egypt and University of Hiroshima, Japan. He became an Assistant Professor at the Biochemistry Department of Cairo University, Egypt in September 1996, and advanced to Associate Professor in September 2002, as well as full Professor in March 2007. His

research interests are in the fields of plant biotechnology and medicinal plants (Molecular Biology). He received 2 patents, wrote 7 international books, published more than 65 SCI Journal papers, and 30 conference presentations. He served as the technique committee member, chair in many international conferences and as editor including PLoS ONE journal, BMC Genomics. He also served as reviewer for more than 10 SCI cited journals. He received several awards, including State prize awarded from Academy of Science, Egypt (2004), Young Arab Researcher prize Awarded from Shuman Foundation, Jordan (2005), State Excellence prize from Academy of Science, Egypt (2011), Cairo University Prizes 2007, 2010.

Contents

**Preface VII**

**Rational Design 35**

**Complication 75**

**Weight Loss 107** Melanie A. Jordan

**Discovery 177**

Taosheng Chen

**Infectious Disease 157**

Chapter 1 **Fruit/Vegetable-Drug Interactions: Effects on Drug**

Chapter 2 **Anticancer Drug Discovery — From Serendipity to**

**Metabolizing Enzymes and Drug Transporters 1** Lourdes Rodríguez-Fragoso and Jorge Reyes-Esparza

Jolanta Natalia Latosińska and Magdalena Latosińska

Chapter 3 **Drug Interactions, Pharmacogenomics and Cardiovascular**

Chapter 4 **Interactions with Drugs and Dietary Supplements Used For**

Elizabeth Hong-Geller and Sofiya Micheva-Viteva

Chapter 6 **Practical Considerations of Liquid Handling Devices in Drug**

Chapter 7 **Data Analysis Approaches in High Throughput Screening 201** Asli N. Goktug, Sergio C. Chai and Taosheng Chen

Chapter 8 **Oxidative Stress in Human Infectious Diseases – Present and Current Knowledge About Its Druggability 227** Carsten Wrenger, Isolmar Schettert and Eva Liebau

Sergio C. Chai, Asli N. Goktug, Jimmy Cui, Jonathan Low and

Irina Piatkov, Trudi Jones and Mark McLean

Chapter 5 **Small Molecule Screens to Identify Inhibitors of**
