**6. Conclusion and future issues**

While the antibacterial resistance, especially multi-drug resistance continues to rise, what we should do is to investigate the potential mechanisms of drug resistance in bacteria and discover more effective antibacterials to deal with the terrible problems. Luckily there are several promising antibacterial drugs with novel mechanisms of action are in development and new types of targets have emerged. Also we need to be more precise in targeting the pathogens and limit the misuse of antimicrobials and other practices that accelerate the emergence of novel resistance mechanisms. The government must offer robust financial in‐ centives for antibacterial R&D, and build a sustainable model for developing and using anti‐ bacterials.
