**Author details**

Asli N. Goktug, Sergio C. Chai and Taosheng Chen

High Throughput Screening Center, Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, USA

for genome-scale RNAi screens. *Journal of Biomolecular Screening*, Vol. 13, No. 2, pp.

Data Analysis Approaches in High Throughput Screening

http://dx.doi.org/10.5772/52508

221

[11] Coma, I., Herranz, J., & Martin, J. (2009). Statistics and decision making in highthroughput screening. In: *High Throughput Screening, Methods in Molecular Biology, Methods and Protocols*, Janzen, W. P. & Bernasconi, P., pp. 69-106, Humana Press,

[12] Copeland, R. A. (2003). Mechanistic considerations in high-throughput screening.

[13] Copeland, R. A. (2005). *Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists*, John Wiley & Sons, ISBN 978-0-471-68696-5,

[14] Echeverri, C. J., Beachy, P. A., Baum, B., Boutros, M., Buchholz, F., Chanda, S. K., Downward, J., Ellenberg, J., Fraser, A. G., Hacohen, N., Hahn, W. C., Jackson, A. L.,Kiger, A., Linsley, P. S., Lum, L., Ma, Y., Mathey-Prevot, B., Root, D. E., Sabatini, D. M., Taipale, J., Perrimon, N.,& Bernards, R. (2006). Minimizing the risk of report‐ ing false positives in large-scale RNAi screens. *Nature Methods*, Vol. 3, No. 10, pp.

[15] Entzeroth, M., Flotow, H.,& Condron, P.(2009). Overview of high-throughput screen‐ ing. In: *Current Protocols in Pharmacology*, pp. 9.4.1-27, John Wiley & Sons, Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/0471141755.ph0904s44/abstract

[16] Gillet, V. J. (2008). New directions in library design and analysis. *Current Opinion in*

[17] Gribbon, P., Lyons, R., Laflin, P., Bradley, J., Chambers, C., Williams, B. S., Keighley, W., & Sewing, A. (2005). Evaluating real-life high-throughput screening data. *Journal*

[18] Gunter, B., Brideau, C., Pikounis, B., &Liaw, A. (2003). Statistical and graphical meth‐ ods for quality control determination of high-throughput screening data. *Journal of*

[19] Hampel, F. R. (1971). A General qualitative definition of robustness. *The Annals ofMa‐*

[20] Hampel, F. R., Ronchetti, E. M., Rousseeuw, P. J.,& Stahel, W. A. (1986). *Robust Statis‐ tics: The Approach Based on Influence Functions.* John Wiley & Sons, ISBN

[21] Harper, G., & Pickett, S. D. (2006). Methods for mining HTS data. *Drug Discovery To‐*

[22] Horn, T., Sandmann, T.,& Boutros, M. (2010). Design and evaluation of genome-wide libraries for RNA interference screens. *Genome Biology*, Vol. 11, No. 6, pp. R61.1-12.

149-58.

777-79.

ISBN 9781603272575, New York.

Hoboken, New Jersey.

*Analytical Biochemistry*, Vol. 320, No. 1, pp. 1-12.

*Chemical Biology*, Vol. 12, No. 3, pp. 372-78.

*of Biomolecular Screening,* Vol. 10, No. 2, pp. 99-107.

*Biomolecular Screening*, Vol. 8, No. 6, pp. 624-33.

*thematical Statistics*, Vol. 42, No. 6, pp. 1887-96.

9780471829218, New York.

*day*, Vol. 11, No. 16-16, pp. 694-99.
