*3.3.2. Apc min/+ mice*

The multiple intestinal neoplasia (Min) mouse was identified following random mutagene‐ sis with ethylnitrosourea [67]. A mutation in the Apc gene was identified as the cause of the disease, like in the human Familial Adenomatous Polyposys (FAP). However, Although Apcmin/+ mice spontaneously form a large number of benign adenomas in the small intestine, colon tumors develop in fewer than half of the animals, in contrast to human FAP patients which routinely develop invasive carcinomas.
