**4. Conclusion**

The development of relevant and predictive models is key to increase the quality of preclini‐ cal researches and to increase the success rate of new drugs. Many progresses have been made in this area to get as closer as possible to *in vivo* situations of human CRC cancers. Even though cell lines and animal models are still indispensable, the Xenograft Models, EVOCs as well as the 3D culture of CRC cancer cells hold the promises for the development of new, more efficient and safer drugs.
