**Frequently, there is need to conduct further laboratory testing in order to determine the existence of infection in different parts of body. Examples of some of these tests may be:**

Lumbar Puncture (During this procedure doctor inject a thin needle into the lower part of backbone to obtain a small amount of spinal fluid. Lumbar liquid helps diagnose disease in the brain and spinal cord), analysis of urine, X-ray of thorax.

#### **What kind of treatment is conducted for newborns with sepsis?**

Most treatment is conducted in hospitals. Doctor will prescribe antibiotics (drug against infection) for your baby. The drug is given intravenously via a tube called an 'IV'.

#### **Algorithm of management for suspected neonatal sepsis**

**Note:** 1 ml. is sufficient for bacterial analysis of blood if a pediatric bottle is used. All material will be used for aerobic culture therefore anaerobic organisms rarely cause early neonatal sepsis. If there is a catheter, blood is obtained simultaneously from the central and peripheral catheter.

It is desirable that diagnostic tests be repeated 24 hours after the first examination. [11]

Early Detection and Prevention of Neonatal Sepsis 17

culture of urine when the age of neonate is at least 6 days old and a culture obtained

7. Differential diagnosis of sepsis must be conducted with other suspected systemic infections, neonatal hypoxia, congenital metabolic abnormalities of metabolism and

Despites the fact that full-term and premature neonates acquiring sepsis is low, the possibility of serious consequences including death is so high that there is the need to conduct an immediate diagnoses and treatment of possible sepsis in neonates regardless of

[2] Micah Bhatti, Alison Chu, Joseph R. Hageman, Michael Schreiber and Kenneth Alexander: "Future Directions in the Evaluation and Management of Neonatal Sepsis";

[3] Jennifer R. Verani, MD, Lesley McGee, PhD, Stephanie J. Schrag, DPhil: Centers for Disease Control and Prevention (CDC): *"Prevention of Perinatal Group B Streptococcal* 

[4] Hammad A. Ganatra, MBBSa, Barbara J. Stoll, MDb,Anita K.M. Zaidi, MBBS,*Sma* 

[5] Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD neonatal research network. Pediatrics.

[7] *Hotchsepsis. Department of Anestkiss RS, Karl IE, The pathophysiology and treatment of* 

[10] Orr, P.A., Case, K.O., & Stevenson, J..J. "*Metabolic response and parenteral nutrition in trauma sepsis and burns Journal of Infusion Nursing";* 2002. 25(1), 45-53. Retrieved March 7,

http://www.emedicine.com/MED/topic2101.htm (Accessed February 14, 2006) [9] Gabay C, Kushner I. *"Acute-phase proteins and other systemic responses to inflammation".* 

New England Journal of Medicine; 1999;340(6):448–4; with permission

http://www.cdc.gov/groupbstrep/guidelines/new-differences.html (2010)

*"International Perspective on Early-Onset Neonatal Sepsis";* 2010

[6] J. Garcia-Prats et al., Semin*"Pediatric Infectional Disease",* 20 00;11:4

*hesiology, Washington University School of Medicine, 2003* [8] Sharma, S. & Mink, S. (2004). Emedicine: "*Septic Shock"*.

from other possible infections of nidus.

neonatal respiratory distress.

gestational age or body weight at birth.

*Georgian National Academy of Sciences, Georgia* 

*Neoreviews* 2012;13;e103 DOI: 10.1542/neo.13-2-e103 http://neoreviews.aappublications.org/content/13/2/e103

[1] Nemsadze K. *"Neonatology",* 2010

*Disease RevisedGuidelines*(GBS)":

2002;110:285-291.

2006 from Ovid database

**Author details** 

Ketevan Nemsadze

**13. References** 

**Figure 7.** Therapeutic guidelines in neonatal infection 2011[11]
