**7. Conclusions**

There is a rational to use of IVIG in either adjunctive treatment neonatal sepsis or in the prevention by low immunoglobulin levels associated with the immature innate immune system of preterm infants. Studies so far revealed a benefit for IgM enriched IVIG in the use as adjunctive sepsis treatment by an overall significantly reduced mortality rate. Prophylactic use of IVIG resulted in marginally reduced rates of nosocomial infections, and other non-invasive approaches like use of lactoferrin (53) and/or probiotics (54) seem to be more promising in the prevention of nosocomial infections in very low birth weight infants.
