**5. Acknowledgments**

This work was supported by grants from the INBB, Ministero dell'Universita` e della Ricerca Scientifica (Progetti di Rilevante Interesse Nazionale 2002, 2003, 2005, 2006; FIRB 2001). Support from the National Center of Excellence in Molecular Medicine (MIUR - Rome) and from the Regional Center of Competence (CRdC ATIBB, Regione Campania – Naples) is gratefully acknowledged. The authors declare that this paper is novel and does not overlap with any already published articles.
