**4. Virus induced cell signalling and global aspects of cellular signalling responses**

Thus far we have discussed a large number of parallel signalling molecules and pathways that are simultaneously activated during CVB3 infection, from proteolytic death pathways to phospho-signalling kinase cascades that activate a myriad of functions. Systems biology approaches now exist whereby one may survey a large number of pathways and molecules at the same time, query these results using complex statistical methods and elucidate the pathways that are truly required for a particular pathogenic function, and determine which of those that are merely coincident to viral infection.
