**3. Discussion**

96 Keratoplasties – Surgical Techniques and Complications

had a ground glass appearance. UBM showed that the BDI lens was in the right position. The lens was sutured. DSAEK was uneventful. 1 month after DSAEK, the patient suffered an ocular hypertony that couldn't be controlled by medication. Ciliary body photocoagulation was undertaken to lower the IOP. The last follow-up visit was 2 month

A 79-year-old man present with bullous keratopathy in his right eye. He underwent traumatic cataract extraction and BDI lens implantation in 2003. On examination, his bestcorrected visual acuity was hand motion in the right, and the IOP was within the normal limits without medication. DSAEK was performed using a neonate donor. The graft markedly contracted during the first postoperative week. Two months later, the patient received a second surgery to exchange the graft. No postoperative complications occurred this time. The last follow-up visit was 3 month after the second DSAEK, the visual acuity

The DSAEK basic procedures were same with the reported by Terry. The implants was prepared by using a Moria (Antony, France) automated microkeratome and a Moria

**B** 

**D** 

Fig. 3. (case 3) Slit lamp photograph (A) and AS-OCT (B) shows the donor tissue shrink during the first postoperative week. (C) and (D) shows the newly exchanged donor disc is

after DSAEK, her IOP was 12 mmHg, and visual acuity was 0.12.

**2.3 Case 3** 

improved to 0.1. IOP was good.

artificial chamber.

**A** 

**C** 

well attached.

Most manipulations during the DSAEK surgery are performed in the anterior chamber. In addition, at the end of the surgery, air bubble is introduced into the anterior chamber to support the donor graft. Therefore, the stability of the anterior chamber is a critical factor in DSAEK. The natural iris-lens diaphragm is a barrier separating the anterior chamber from posterior vitreous cavity. Patients with anatomically or functionally anomalous iris-lens diaphragm are challenges to DSAEK. Small case series of DSAEK/DSEK were reported in patients with intraoperative floppy-iris syndrome, aphakic patients and aniridic aphakic patients.1,2,3 The results were largely favorable with some modification of the surgical technique. Bradley et al. described a suture-drag technique to minimize intraoperative donor endothelial trauma in patients with intraoperative floppy-iris syndrome.1 Price et al. used anchor suture securing the donor to the recipient to prevent the donor tissue from dropping down to the retina in aniridic aphakic eyes.2 However, since the main purpose of DSAEK is to improve vision, we think it should be more appropriate to correct aphakia and aniridia either prior to or at the same time with DSAEK surgery. Aniridic aphakic patients would benefit from BDI lens that could in some extent compensate optically the loss of iris and crystal lens. However, the BDI lens is not an ideal barrier to maintain a stable anterior chamber compared with the natural iris-lens diaphragm. There is gap between the haptics and the black diaphragm, especially in the traumatic cases without capsular remnants. Therefore, after a 5mm incision was made in DSAEK, the pressure in the anterior chamber will decrease, thus it is unavoidable that the liquefied vitreous humor will go through the gap into the anterior chamber and the pressure of the posterior segment will decline. Anterior irrigation during graft insertion is not enough to compensate this occult vitrous loss. In the presence of pressure difference between the anterior and posterior segment, when the air bubble was injected into the anterior chamber, it would easily go back to the vitreous cavity postoperatively just like what we observed in case 1 in which the graft was found partially detached and the air bubble was totally disappeared on the first postoperative day. Therefore, when DSAEK is considered in an aniridic patient with BDI lens, we recommend that the pressure difference should be balanced first before the donor was unfolded by the air bubble.

Glaucoma is a common complication for both traumatic and congenital aniridia. In the traumatic eye, the trabecular meshwork could easily be jeopardized in the presence of extensive loss of iris tissue. Likewise, anomalous development of the anterior chamber angle in congenital aniridia could result in progressive IOP elevation.4 In addition, the prevalence of glaucoma will further increased after BDI lens implantation.5,6 It was ascribed to the continuous irritation of the haptics and the diaphragm to the uveal remnants in congenital aniridia, which may alter the blood–aqueous barrier, accelerating glaucoma progression.<sup>5</sup> It was also proposed that the large size of the BDI lens may impair aqueous outflow by direct compression on the anterior chamber angle.6 In some cases the haptics of the lens were found not rest in the ciliary sulcus but in the anterior chamber angle.5 Therefore, use of type 67G BDI lens with smaller haptic diameter (12.5mm) was recommend.6 Glaucoma was observed in two of our patients (case 1 and case 2) before DSAEK, but could be controlled medically. During the postoperative follow-up, case 1 had a temporary IOP rise, and case 2 experienced a persistent hypertony that was successfully treated with cyclophotocoagulation. In our case series, all three patients were implanted with 67G BDI lens, and the UBM prior to DSAEK surgery showed the haptics of the lens were not in

**Part 3** 

**Complications of Keratoplasties** 

contact with the trabecular meshwork. Therefore, we think angle compression by the haptics is not a major cause for IOP elevation in our cases. However, we do believe that glaucoma is an issue that deserves special attention when DSAEK is planned to be undertaken in aniridic cases with BDI lens. A well control of IOP preoperatively and close postoperative follow-up to monitor the IOP is recommended.

It is also essential to find out the main reasons for endothelial decompensation in these three cases. Trauma can cause endothelial loss. Congenital aniridia could also associate with endothelial deficiency, although the most common corneal change is limbal stem cell deficiency.7,8 Normally, the BDI lens was sutured to the ciliary sulcus, it should has no friction with the endothelium unless the BDI lens is decentered or displaced anteriorly.5,6 In our three patients, UBM showed that the BDI lens were in the right position, and the endothelial cell counts before BDI lens implantation were already lower than the normal value. We think that BDI lens did not contribute to endothelial cell loss in our three cases, and thus it was not necessary to remove the lens during DSAEK.

#### **4. References**

