**1. Introduction**

156 Viscoelasticity – From Theory to Biological Applications

2006 Feb;39(2):195-21.

[140] Lim CT, Zhou EH, Quek ST. Mechanical models for living cells--a review.. J Biomech

Skin is the largest organ in humans and protects the body from environmental factors. The dermis is a layer that acts to protect the body from external physical force. Viscoelasticity is essential to facilitate the physical function of the skin. However, the clinical-biological-physical relevance of dermal connective tissue has not been fully investigated. In this chapter, we review past studies in this vast field and attempt to elucidate the combined clinical-biologicalphysical relevance of dermal connective tissue. In addition, we discuss Tarumi disease, which is characterized by impaired viscoelasticity and stiffness in connective tissues.
