**2. Biomechanical approach. Method grounds**

This new approach has its foundation in the integration, through appropriate relations, of factors from different natures (biological, structural and geometric) and scales (temporal and dimensional) at the molecular, cellular, tissue and organ levels (from bottom level to top level), which allow to describe, from quantitatively point of view, the aneurysm progression and its rupture potential.

These defined relations are known as biomechanical factors or biomechanical determinants (BDs).

The basic premise of the biomechanical approach to estimate the AAA rupture risk, is that this phenomenon follows the principle of material failure, that is, an aneurysm ruptures when the stresses acting on the arterial wall exceeding its failure strength, reflecting the interaction between the arterial wall structural remodelling and the forces generated by blood flow within the AAA.
