**3. Antihypertensive effects in vivo**

The search for *in vitro* ACEI is the most common strategy followed in the selection of potential antihypertensive peptides derived from food proteins. *In vitro* ACEI activity is generally measured by monitoring the conversion of an appropriate substrate by ACE in the presence and absence of inhibitors. The antihypertensive effects have been assessed by *in vivo* experiments using spontaneously hypertensive rats (SHR) as an animal model to study human essential hypertension [7]. Following a positive response in animal studies human studies may be carried out to ascertain the ACEI potential
