**12. Coreceptor usage in HIV-2**

Studies have shown that the use of coreceptors is much broader in HIV-2 infections relative to HIV-1. In addition to CCR5 and CXCR4 HIV-2 is able to utilise alternative coreceptors such as GPR15, or CXCR6 and to a lesser extent CCR1, CCR2b or CCR3 in aviremic patients whilst CXCR4 is only used in viremic individuals. It still needs to be explored whether this wide use of coreceptors is the underlying reason behind the less virulent phenotype associated with HIV-2, compared to HIV-1.
