**5.1. Natural treatment paradigm**

The natural therapy must help the body's internal corrective actions to reestablish the healthy state. In normal healthy state the body is in homeostasis, which is controlled by numerous negative feedback loops, making the actual state definitely "constant" despite its energetically open status, (see Figure 45.). The disease breaks up the relative equilibrium, and the body tries to reestablish the homeostasis. For this enhanced negative feedback control is enforced (see Figure 46.). Recognizing the disease, we act with our medical knowledge, and in many cases, we work against the natural homeostasis, the constrained action induces new homeostatic negative feedback. The body starts to fight against our constraints together with the disease (see Figure 47.). This controversial situation happens with classical hyperthermia, when the constrained massive temperature change is physiologically down-regulated (or at least the physiology works against it by the systemic [like blood-flow] and local [like HSP] reactions). Oncothermia disclaims the old approach, introducing a new paradigm: with the application of micro-heating, it induces considerably less physiological feedback to work against the action, and with the application of the electric field it uses such effect, for which the body has no physiological answer. With this new paradigm, oncothermia helps the natural feedback mechanisms to reestablish the healthy state (see Figure 48.).

54 Hyperthermia

objectively measured.

oncothermia way.

*4.4.2. Comparison of pancreas efficacy studies I. & II* 

**5. Future – To join or not to join?** 

**5.1. Natural treatment paradigm** 

No serious side effects were observed [403]. Patients tolerated the treatments well during the whole treatment period. Most of the patients were well relaxed, some even fell asleep during the treatment. Patients reported better quality of life, but this information was not

The results well indicate the feasibility and the benefit of the oncothermia showing a valid treatment potential and safe application. Oncothermia is a potential way to escape from the present impasse situation and could treat brain gliomas successfully. Question of Editorial of JAMA "Where to go from here?" [404] could be answered with the help of the

For clear evidence of the results, let us compare the first year survivals and the median survivals obtained in various clinics in comparison to the historical control and the large databases. The weighted average of five clinics of the first year survival percentages and the median survival times are 47.5 % and 12.4 months for oncothermia, while the references

Oncothermia formulated a new paradigm: [72], and made it clear "What is against the acceptance of hyperthermia?" [83]. The problem is the misleading aim of getting uncontrollable temperature as dose and ignoring the physiological reaction of the patients.

The philosophy of oncothermia simply follows the line of Hypocrates: "Nil Nocere" ("Do not harm"). Of course this has to be understood as "be natural as much as possible". Oncothermia supports the natural processes of living organisms, applying the normal physiological and biophysical reactions of the body, using these to fight against the malignancy on standard way. The basic problem of the malignancy is that the immune system and all the protective mechanisms of the organism do not fight against this lesion, do not recognize the danger, they handle it as a normal tissue, supply and try to solve the irregularities, if it was a wound. By the appropriate selective mechanism, oncothermia is able to "discover" these irregularities, showing their differences from the normal tissue and

The natural therapy must help the body's internal corrective actions to reestablish the healthy state. In normal healthy state the body is in homeostasis, which is controlled by numerous negative feedback loops, making the actual state definitely "constant" despite its energetically open status, (see Figure 45.). The disease breaks up the relative equilibrium, and the body tries to reestablish the homeostasis. For this enhanced negative feedback control is enforced (see Figure 46.). Recognizing the disease, we act with our medical knowledge, and in many cases, we work against the natural homeostasis, the constrained

(large databases SEER and EUROCARE) show 15.6 % and 7.3 months, respectively.

activate the standard protective, defense mechanisms in the body to fight.

**Figure 45.** The natural healthy state is stabilized by the negative feedback loops of physiology

**Figure 46.** The disease breaks the homeostasis, so the physiology tries to compensate and correct the damage

Local Hyperthermia in Oncology – To Choose or not to Choose? 57

The lowering of the pH of the tumor is also a positive feedback loop. By the blocking of

The injury current loop also has positive feedback. This is broken by the flow of the

 The neoangiogenesis is also a positive feedback, supporting the tumor by its accelerated nutrition demand. The electric current prefers the new vessels for conduction, blocking

 The growing temperature decreases the impedance (increases the conductance by the mobility of the ions) in the tumor. This positive feedback loop is used till the temperature does not increase too much. The step-up heating uses this effect and

 The growing temperature blocks the blood-flow in the tumor, which traps the heat in the center of the tumor. The heat-trap makes necrosis in the center of the tumor, which is anyway very acidic, and in most cases it is necrotized naturally. In artificial focusing, this necrotized volume remains the main target, however it does not need more energy. The real danger of the tumor is the vividly living outer "shell" which is responsible for metastases and for the volume-occupying rapid growth as well. The oncothermia current flows through this "shell" irrespective of how large the necrotic center is, and makes the oncothermia effective. It is shown, that after oncothermia the proliferation activity is drastically suppressed even in the possible remaining tumor tissue, which of

Hyperthermia is an ancient treatment. It was the very first one in oncology, but it could not find its established place among the "gold standards" of the oncotherapies. The controversial results were originated from the paradigm to constrain the temperature growth in the process. The constrained forces made physiological contra-reactions keep the homeostasis, which unfortunately contains the malignant tissue as well. The actions have to be selective, and have

Oncothermia selects the malignant cells and acts differently from the physiological homeostatic reactions (heat-flow on the membrane supported by the electric field effects). It is natural, it is not against the homeostasis and physiology does not work against the action. The main task is to direct the physiology in the standard way, and act on such normal line. The positive feedback loops (the avalanche effects), which may destroy the normal

to be gentle enough to work together with the natural processes, and not against them.

the high metabolic rate, the pH-loop is eliminated as well.

course was massively targeted by the RF current.

homeostatic equilibrium have to be stopped.

It elongates the survival time of the patients,

It is a personalized therapy,

It has good cost/benefit ratio

It is non- toxic,

Oncothermia follows the update demands of the modern oncology:

It completes the curative actions with increased quality of life

electric current density.

their actions.

**5.2. Epilogue** 

controls this loop.

**Figure 47.** The classical hyperthermia introduces a new constrained effect which induces even more physiological feedback, forcing the body for the "double front" fight

**Figure 48.** Oncothermia acts differently. It helps the natural feedback loops for natural corrections

Oncothermia blocks the physiological positive feedbacks, reestablishes the homeostasis to the level, which the actual conditions allow. The blocks are effective:

 The growth of cancer itself has a positive feedback loop. The rate of proliferation depends on the actual mass of the tumor, so the tumor mass gradually grows. Selective blocking of malignant autonomy could eliminate the positive feedback loop of malignancy.

