**4.2. Suppressing the dissemination of malignant cells**

Oncothermia is different from this point of view as well. It blocks the dissemination, avoids their motility due to the lazy connections with the tumor. Oncothermia makes it by the reestablishing the cellular connections (see Figure 41. [337]), which is also great success to save life. The built up connections can force not only the sticking together, but make bridges between the cells for information exchange to limit the individuality and the competitive behavior of the malignant cells.

**Figure 41.** Oncothermia can reestablish the adherent cell connections (E-cadherin and β-catenin) as well as the gap-junctions (Connexin-43). These could reestablish the cellular communication and can stop the dissemination of tumor cells

This "gluing mechanism" is not only important for the external apoptotic signal, but makes the malignant cells less mobile, their motility is reduced and the dissemination risk is decreased.
