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**Chapter 4** 

© 2013 Lahonian, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2013 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,

**Diffusion of Magnetic Nanoparticles** 

Hyperthermia is one of many techniques used in oncology. It uses the physical methods to heat certain organ or tissue delivering an adequate temperature in an appropriate period of time (thermal dose), to the entire tumor volume for achieving optimal therapeutic results. Thermal dose has been identified as one of the most important factors which, influences the efficacy of hyperthermia [Perez and Sapareto (1984)]. Although there are definite prescriptions for temperature (generally 43 ℃) and time (usually �� ���), variations in the temperature and time of delivery are frequent throughout the treatment sessions [Perez and

The effectiveness of hyperthermia treatment is related to the temperature achieved during the treatment. An ideal hyperthermia treatment should selectively destroy the tumor cells without damaging the surrounding healthy tissue. [Andrä *et al.* (1999), Lagendijk (2000), Moroz *et al.* (2002), Maenosono and Saita (2006), Lin and Liu (2009)]. Therefore, the ability to predict the temperature distribution inside as well as outside the target region as a function

In the past fifteen years, MFH has drawn greater attention due to the potential advantages for cancer hyperthermia therapy. In MFH, a nanofluid containing the MNPs is injected directly into the tumor. An alternating magnetic field is then applied to the target region, and then MNPs generate heat according to Néel relaxation and Brownian rotation losses as localized heat sources [Jordan *et al.* (1999), Jordan *et al.* (2001), Thiesen and Jordan (2008)]. The heat generated increases the temperature of the tumor. In general, the cancerous cells possess a higher chance to die when the temperature is above 43 ℃ whereas healthy cells

and reproduction in any medium, provided the original work is properly cited.

Sapareto (1984), Jordan *et al.* (1999), Jordan *et al.* (2001), Overgaard *et al.* (2009)].

of the exposure time, possesses a high degree of importance.

will be safe at this temperature [Andrä *et al.* (1999), Moroz *et al.* (2002)].

**Within a Biological Tissue During** 

**Magnetic Fluid Hyperthermia** 

Additional information is available at the end of the chapter

Mansour Lahonian

**1. Introduction** 

http://dx.doi.org/10.5772/52305

