**2. Heat dissipation of MNPs**

In MFH, after introducing the MNPs into the tumor (Figure 1), an alternating magnetic field is applied. This causes an increase in the tumor temperature and subsequent tumor regression. The temperature that can be achieved in the tissue strongly depends on the properties of the magnetic material used, the frequency and the strength of the applied magnetic field, duration of application of the magnetic field, and dispersion of the MNPs within the tissue.
