**7. Heat-activated drug delivery**

An exciting new generation of clinical trials is now harnessing drug-containing thermosensitive liposomes, and other nanoparticle drug carriers, that release contained chemotherapy agents upon heating above ~40 °C. Combined with localized heating methods as described above, this allows for targeted chemotherapy delivery to tumors. Thermal ablation or hyperthermia can be combined with heat-activated drug carriers to selectively deposit chemotherapy in the heated area. Initial clinical trial results suggest patient benefits from this combination and thus there is considerable excitement among members of our Society in this approach.
