**5.2. Epilogue**

56 Hyperthermia

**Figure 47.** The classical hyperthermia introduces a new constrained effect which induces even more

**Figure 48.** Oncothermia acts differently. It helps the natural feedback loops for natural corrections

the level, which the actual conditions allow. The blocks are effective:

malignancy.

Oncothermia blocks the physiological positive feedbacks, reestablishes the homeostasis to

 The growth of cancer itself has a positive feedback loop. The rate of proliferation depends on the actual mass of the tumor, so the tumor mass gradually grows. Selective blocking of malignant autonomy could eliminate the positive feedback loop of

physiological feedback, forcing the body for the "double front" fight

Hyperthermia is an ancient treatment. It was the very first one in oncology, but it could not find its established place among the "gold standards" of the oncotherapies. The controversial results were originated from the paradigm to constrain the temperature growth in the process. The constrained forces made physiological contra-reactions keep the homeostasis, which unfortunately contains the malignant tissue as well. The actions have to be selective, and have to be gentle enough to work together with the natural processes, and not against them.

Oncothermia selects the malignant cells and acts differently from the physiological homeostatic reactions (heat-flow on the membrane supported by the electric field effects). It is natural, it is not against the homeostasis and physiology does not work against the action. The main task is to direct the physiology in the standard way, and act on such normal line. The positive feedback loops (the avalanche effects), which may destroy the normal homeostatic equilibrium have to be stopped.

Oncothermia follows the update demands of the modern oncology:


The introduced new paradigm by oncothermia solved the classical challenges:

 Challenge (1): "The biology is with us while the physics is against us" (Overgard J., [405]).

Local Hyperthermia in Oncology – To Choose or not to Choose? 59

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The task for the future is challenging, and we are expecting professionals to repeat our results and come with us to fight in the war against cancer [407].
