**4. Factors that effects on high levels of CRP**

Many doctors will prescribe taking non steroidal anti-inflammatory drugs ((NSAIDs like aspirin, ibuprofen, and naproxen) or statins may reduce CRP levels in blood. Both antiinflammatory drugs and statins may help to reduce the inflammation, thus reducing CRP. However, there are natural treatments that can help reduce inflammation in the blood. Following are some of the natural treatments for lowering C - reactive protein levels and inflammation in the blood:

94 Blood Cell – An Overview of Studies in Hematology

(Safar et al., 1981[51]; Shaw and Xu, 2003)[52][53].

Diseases of the immune system, such as lupus.

**4. Factors that effects on high levels of CRP** 

Pelvic inflammatory disease (PID)

Connective tissue disease

Pneumococcal pneumonia

 Heart attack Infections

 Rheumatic fever Tuberculosis

 Cancer of the lymph nodes (lymphoma). Infection of a bone (osteomyelitis).

test is therefore useful in assessing patients with the following list[54]:

 Swelling and bleeding of the intestines (inflammatory bowel disease). Painful swelling of the tissues that line the joints (rheumatoid arthritis).

Painful swelling of the blood vessels in the head and neck (giant cell arteritis).

minor CRP elevation and future major cardiovascular events has been recognized, leading to the recommendation by the Centers for Disease Control and the American Heart Association that patients at intermediate risk of coronary heart disease might benefit from measurement of CRP. It is yet to be determined if CRP serves as a marker of heart disease or whether it plays apart in causing atherosclerotic disease (hardening the arteries)[41]. CRP has been shown to have a close relationship with vascular diseases. CRP is a powerful independent risk factor for atherosclerosis and atherosclerosis-related diseases (Lusic et al., 2006 [42]; Verma et al., 2006)[43]. Elevated high-sensitivity CRP (hsCRP) has been measured in the blood of patients with essential hypertension (Li et al., 2005) [44] or abdominal aortic aneurysms (Vainas et al., 2003 [45]; Tambyraja et al., 2007 [46]) with enhanced systemic or local arterial strain. Elevated serum hsCRP independently correlates with blood pressure (Sung et al., 2003)[47], arterial stiffness (Kim et al., 2007) [48], and aneurysmal size (Vainas et al., 2003) [49]. Although several investigations have demonstrated that aneurysmal tissues and diseased coronary artery venous bypass grafts (Jabs et al., 2003)[50] produce CRP, little is known about its mechanism. Blood vessels are dynamically subjected to mechanical strain in the forms of stretch and shear stress that result from blood pressure and blood flow. Mechanical strain on the vessel wall can increase from 15 to 30% in hypertensive individuals

CRP testing is not precise enough to diagnose specific diseases but serves more as a general indicator that more testing may be needed if inflammation or infection is found. The CRP

Many doctors will prescribe taking non steroidal anti-inflammatory drugs ((NSAIDs like aspirin, ibuprofen, and naproxen) or statins may reduce CRP levels in blood. Both antiinflammatory drugs and statins may help to reduce the inflammation, thus reducing CRP. However, there are natural treatments that can help reduce inflammation in the blood. Fish Oil Omega 3 Fatty Acids Doctors and nutritionists have recommended Omega 3's for years, and recently fish oil has been the most recommended source for Omega 3 Fatty Acids. Fish oil contains two of the most therapeutic Omega 3 Fatty Acids the DHA and EPA. These two fatty acids are the most readily absorbed by the body (much more so than the ALA found in flax seed oil), and can help reduce inflammation in the blood among other benefits.

Ginger - Ginger root extract has long been used in Asian cooking, and has been used for centuries as a digestive aid and motion sickness cure, and more recently to lower cholesterol. Ginger can also help reduce inflammation, as it relaxes the muscles surrounding blood vessels and facilitates blood flow throughout the body.

MSM - Methyl Sulfonyl Methane, commonly known as MSM, is a naturally occurring sulfur compound found in some vegetables. MSM is found in many arthritis formulas, and has strong anti-inflammatory properties.

These three nutrients may help reduce CRP levels in your blood. All three are important for maintaining heart health as well as general health and wellbeing [55].

There was a study found a significant effect of treatment for 2 months with 1000 mg/day vitamin C on plasma CRP, in non diseased moderately overweight nonsmokers with baseline CRP ≥1.0 mg/L. The magnitude of the effect was similar to that of statins. There was no significant effect of vitamin E. These data represent the largest study to date on the effects of vitamins C and E on CRP and extend our previous findings in overweight active and passive smokers. They indicate that vitamin C should be further investigated for its potential for reducing chronic inflammation and its consequences. And they identify a threshold concentration above which there is a potential for reduction in CRP. Future studies to determine whether vitamin C can reduce some of the inflammation-related adverse consequences of obesity should be considered. Such trials should focus on individuals with elevations (.1.0 mg/L) in CRP, because studies with low-risk persons are less likely to show an effect, resulted in misleading outcomes. If persons with lower CRP levels must be included, separate randomization of those with CRP .1.0 mg/L would justify separate examination of this subgroup, assuming adequate power in this stratum. In addition, if the potential independent effect of vitamin C is to be determined, it would be necessary to exclude persons who are taking other anti-inflammatory drugs (except lowdose aspirin for heart disease prevention) and to exclude users of multiple vitamins (something which has not been done in most large antioxidant trials), because multiple vitamins alone can raise plasma ascorbic acid levels substantially and make the control group insufficiently different from the active treatment group. Finally, it may be prudent to evaluate vitamin C alone, unpaired with vitamin E, as we found a weaker CRP-lowering effect with the combination than with vitamin C alone in our previous trial [56].
