**2. Adipokines physiological role**

The adipose tissue is considered an endocrine organ and shows great dynamism. Since 1940 there is a hypothesis that adipose tissue has signals to communicate with other tissues [11], but only later was shown that this tissue is able to synthesize and secrete a large number of protein factors (which also act as cytokines) collectively called adipokines. These adipokines, in most part, are related, directly or indirectly, in processes involving atherosclerosis, hypertension, insulin resistance (IR) and type 2 diabetes (DM2), dyslipidemia, ie, represent the link between adiposity, metabolic syndrome and cardiovascular diseases [12-15]. Among these is Leptin, Resistin, Adiponectin, and others such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), acylation stimulating protein (ASP) and factors involved in the reninangiotensin system (RAS).
