**4. Conclusion**

Thus, water-soluble molecular complexes of various polysaccharides and glycyrrhizic acid with drugs that normally dissolve poorly in water have been synthesized and tested for binding strength and pharmacological activity in comparison with the constituent drugs.

The suggested mechanochemical synthesis of solid dispersed systems "drug-complexing agent" ensures high strength of the complexes, on condition of low-energy nondestructive treatment of polysaccharide macromolecules.

Arabinogalactan, a water soluble polysaccharide of *Larix sibirica* Ledeb. and *Larix gmelinii*  (Rupr.), when used as a complexing agent, provides the highest solubility among other studied poly- and oligosaccharides. Another advantage of arabinogalactan is its exceptional, almost infinite, raw material source in the Northern Hemisphere (in Russia and Canada), as well as the availability of extraction and purification technologies [62].

The molecules of poorly water soluble drugs can be carried by micelles that form in water solutions of glycyrrhizic acid. Complexing with polysaccharides, in the same way as with GA, increases the solubility of pharmacons and allows reducing significantly (up to ten times) the effective dose avoiding, at the same time, some unwanted side effects.

Thus, a new perspective is opening of obtaining highly effective and safe drugs and new ways of drug delivery.
