**13. Effects of lipid-lowering therapy on change of apoB, apoA-I and the apo-ratio**

The mode of actions of statins and their effects on lipids and apos is reviewed in more detail elsewhere (163-165). The most commonly used drugs today are the statins that can reduce apoB synthesis and increase apoA-I synthesis and turnover. In clinical practice simvastatin and pravastatin are the most commonly used statins since they are now available as generics. They can reduce apoB up to about 20% and increase apoA-I by about 2-5% and a bit more for simvastatin. The most effective apoB-reducing statins are atorvastatin and rosuvastatin which lower the apoB-values by about 40-45% and 45-50%, respectively. Best increase in apoA-I concentrations is obtained by rosuvastatin which can increase the value by about 10-15% depending on baseline values, the lower the higher is the increase (163-165). Commonly for all statins there is a strong dose-response relationship, except for atorvastatin where higher doses commonly result in lowering of HDL-C and apoA-I values. The strongest lowering effects of the apo-ratio is obtained by rosuvastatin which lowers this ratio by about 50 %, followed by atorvastatin about 40-45 %, and simvastatin and pravastatin up to 30 %.
