**5. Conclusion**

Overall of the studies SERMs/aromatase inhibitors raloxifene or exemestane may be better alternatives to tamoxifen or letrozole treatment in terms of effects on cognitive deficits and overall health risk in women treated with chemotherapy. In addition, *ApoE* genotype and cholesterol levels need to be taken into account when examining efficacy of these drugs and in hormone replacement therapies as efficacy is dependent on *ApoE* genotype. Knowing these issues will help doctors to address them early for improving quality of life, reducing services used and saving millions of dollars in unneeded medical expenses. Realistically, the wonder drug that can cure all cancer and has no side effects will not be found. What is needed is to reduce the impact and intensity of cognitive side-effects as much as possible, taking into account an individual's physiology and genetics. The more we know about cognitive status across ages, ethnicity, lipid levels, and genetic status the better we can treat mind and body.
