**1. Introduction**

Adipose tissue as a substantial part of the human body contains about 10 % of body mass. It serves both as a reservoir of the energy storage and the active endocrine tissue producing many proactive substances including adipokines. These molecules have many important metabolic effects [1]. Adiponectin is an adipose tissue-derived adipokine which circulates at relatively high concentrations in blood. It has protective role in the initiation and progression of atherosclerosis through its antiinflammatory and antiatherogenic effects. Adiponectin serum levels are decreased in obesity, type 2 diabetes, and patients with coronary artery disease, etc [2]. The level of circulating adiponectin correlates positively with HDL cholesterol, and negatively with inflammatory markers, markers of insulin resistance, triglyceride-rich lipoprotein particles, and other adipokines. Adiponectin disposes of protective actions on development of various obesity-linked diseases. The antiinflammatory properties may be the major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. In addition, adiponectin displays a direct biological activity through the induction of a classical pathway of complement activation.
