**1. Introduction**

336 Lipoproteins – Role in Health and Diseases

oxidation. Atherosclerosis. 137: 49

[260] Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J (1998) The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its

[261] Fuhrman B, Volkova N, Kaplan M, Presser D, Attias J, Hayek T, et al (2002) Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma

lipid levels, and decreased systolic blood pressure. Nutrition. 18: 268-273.

Cyclosporin A (CsA) is an immunosuppressant drug widely used in organ transplant recipients and patients with auto-immune disorders. Long-term treatment with CsA is associated with hyperlipidemia and an increased risk of atherosclerosis. The mechanisms by which cyclosporin A causes hyperlipidemia are unclear. Cell and animal studies have pointed to various mechanisms that may mediate CsA-induced hyperlipidemia. In this review we will give an overview of CsA-induced hyperlipidemia, with a focus on the data available that might explain the underlying mechanism(s) and describe the available treatment regimes used to treat hyperlipidemia induced by immunosuppressant drugs.
