**7. References**


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66 Lipoproteins – Role in Health and Diseases

**Author details** 

D.S. Mshelia and A.A. Kullima

**Acknowledgement** 

**7. References** 

state of Supraphysiologic hyperlipidaemia, defined as lipid levels greater than 95th percentile for the corresponding gestational age, because of failed adaptation to requirement of pregnancy. Supraphysiologic hyperlipidaemia may serve as a marker for what is cited by Montes[99], et al, a 'prelipaemia' in the same way that GDM is a marker for pre-diabetes.

The characteristics of Supraphysiologic hyperlipidaemia, as observed by Montes[99], et al, are that, the antepartum hyperlipidaemia may return to normal levels postpartum more slowly than normal, the presence of HDL cholesterol concentrations that are persistently low antepartum and postpartum, and the patients do have hyperlipidaemic family members. In contrast, hypercholesterolemia is not greatly exaggerated in pregnancy among these women. Are there future consequences of the pregnancy-induced Supraphysiologic hyperlipidaemia? Long-term follow-up studies of women with genetically wellcharacterized disorders of lipoprotein metabolism are required to determine if an abnormal lipoprotein response in pregnancy can identify prelipaemic subjects and distinguish among the major disorders of lipoprotein metabolism. Identification of the prelipaemia will provide an opportunity to study prospectively the natural progression, potential for atherosclerosis,

I, D.S. Mshelia, greatly appreciate the support given to me by my lovely wife, Aisha A Buba and my children. Similarly, I, A.A. Kullim, sincerely appreciate the support given to me by

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81(8): 1038-1043

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[59] Superko HR and King S 111 (2008). Lipid management to reduce cardiovascular risk: a

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