**Author details**

168 Lipoproteins – Role in Health and Diseases

**Figure 10.** Anexample of Medience interface [19]

hypercholesterolemia and related publications.

their help various data sources involved.

It is therefore possible through a platform like Medience to integrate data sources (BD, Excel files, and text files) and view the results in a tabular form. Now, we can process to the analysis of the results. For this, the definition of demand in terms of mining must be decided: How can we use the data provided. Medience offers the possibility to ask tables on the global schema in SQL way. It also offers the ability to define views on these tables and keep a small part that is particularly interesting. It is possible to use our tool to answer the question like what is the protein associated with the mutated gene responsible for familial

The objective of this work was to develop a system for integrating biological data with an application on familial hypercholesterolemia disease. Such a system should facilitate access to multiple data sources available on the Web, in a transparent and uniform way, giving biologists a single virtual source that summarizes all relevant data sources for the application. This chapter describes the solution adopted to achieve such a system, where the main elements have been identified, and a computer deployment scenario developed. Among different existing integration approaches, we adopted the mediator approach to integrate data sources. In this approach the most important step is the construction of the global schema as the mediator has to process queries at runtime in order to integrate data sources. We first studied the biologists' needs by exploring different scenarios and we identified with

**6.4. Step 4: Data analysis** 

**7. Conclusion** 

Assia Rharbi and Zohra Bakkoury *Equipe : AMIPS Ecole Mohammadia des Ingénieurs, Université Mohammed V, Agdal, Rabat – Morocco* 

Afaf Mikou *Laboratoire GAIA, Spectroscopie Faculté des Sciences Ain Chock – Université Hassan II, Casablanca – Morocco* 

Khadija Amine

*Laboratoire GAIA, Spectroscopie Faculté des Sciences Ain Chock - Université Hassan II, Casablanca – Morocco Laboratoire de Recherche sur les Lipoprotéine et l'Athérosclérose, Unité de Recherche Associée au CNRS-URAC 34-, Faculté des Sciences Ben Msik-Casablanca, Université Hassan II Mohammedia, Morocco* 

#### Anass Kettani

*Laboratoire de Recherche sur les Lipoprotéine et l'Athérosclérose, Unité de Recherche Associée au CNRS-URAC 34-, Faculté des Sciences Ben Msik-Casablanca, Université Hassan II Mohammedia, Morocco* 

Abdelkader Betari *ENSA Oujda, Université Mohammed Premier Oujda, Morocco* 

#### **8. References**


**Hyper- and Dyslipoproteinemias** 

170 Lipoproteins – Role in Health and Diseases

Banques généralistes

Banques spécialisées

Mechanics)

[10] www.rcsb.org/pdb/

[15] http://rasmol.org/

[16] http://jmol.sourceforge.net/

[18] http://www.w3.org/MarkUp/VRML/

Hum Genet.48 (4):199-203, 2003

[4] www.gusdb.org : Genomics Unified Schema (GUS)

[6] http://www.cs.man.ac.uk/~stevensr/tambis/ : TAMBIS

[1] M. El Messal, K. Aït Chihab, R. Chater, JC. Vallvé, F. Bennis, A. Hafidi, J. Ribalta, M. Varret, M. Loutfi, JP. Rabès, A. Kettani, C. Boileau, L. Masana, A. Adlouni. Familial Hypercholesterolemia in Morocco: first report of mutations in the LDL receptor gene. J

[2] http://www.dsi.univ-paris5.fr/bio2/autof2/cha2\_1.htm : Bases de données biologiques /

[3] http://www.dsi.univ-paris5.fr/bio2/autof2/cha2\_2.htm : Bases de données biologiques /

[5] Emilie Guérin, Gwenaëlle Marquet, Anita Burgun, Olivier Loréal et Fouzia Moussouni, GEDAW : un environnement intégré pour l'analyse du Transcriptome, JOBIM 2005

[8] http://www.charmm.org/: CHARMM (Chemistry at HARvard Macromolecular

[12] Assia Rharbi, Zohra Bakkoury, Afaf Mikou, Anass Kettani, Abdelkader Betari, and Omar Boucelma, Intégration des données génomiques pour la maladie d'hypercholestérolémie familiale, Journées Scientifiques en Bio-informatique (JSB'2007) [13] Assia Rharbi, Zohra Bakkoury, Afaf Mikou, Anass Kettani, Abdelkader Betari, and Omar Boucelma, Intégration des données appliquée au domaine biologique, Cinquième

[19] F.-M. Colonna, Thèse : "Intégration de données hétérogènes et distribuées sur le Web et applications à la biologie", Université Paul Cézanne (Aix-Marseille III), Décembre 2008

Conférence sur les Systèmes Intelligents : Théories et Application (SITA'08) [14] http://www.rcsb.org/pdb/file\_formats/pdb/pdbguide2.2/guide2.2\_frame.html

[17] http://fr.wikipedia.org/w/index.php?title=Chime&action=edit&redlink=1

[7] Thomas Hernandez, Subbarao Kambhampati, Integration of Biological Sources:

Current Systems and Challenges Ahead, SIGMOD september 2004

[9] http://www.ks.uiuc.edu/Research/vmd/: VMD (Visual Molecular Dyamic)

[11] http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&itool=toolbar

**8. References** 
