**1. Introduction**

210 Lipid Metabolism

[168] Kang D W, K Y Choi, and S Min do (2011) Phospholipase D meets Wnt signaling: a

[169] Ptaszynska M M, et al. (2008) Positive feedback between vascular endothelial growth

[170] Gaetano C G, et al. (2009) Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma

[171] Cowey S and R W Hardy (2006) The metabolic syndrome: A high-risk state for cancer?

[172] Pothiwala P, S K Jain, and S Yaturu (2009) Metabolic syndrome and cancer. Metab

[173] Braun S, K Bitton-Worms, and D LeRoith (2011) The link between the metabolic

[174] Calle E E, et al. (2003) Overweight, obesity, and mortality from cancer in a

[175] Emily Jane Gallagher R N, Shoshana Yakar , Derek LeRoith (2010) The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms. Principles of Diabetes

prospectively studied cohort of U.S. adults. N Engl J Med. 348: 1625-38.

factor-A and autotaxin in ovarian cancer cells. Mol Cancer Res. 6: 352-63.

new target for cancer therapy. Cancer Res. 71: 293-7.

cells. Mol Carcinog. 48: 801-9.

Syndr Relat Disord. 7: 279-88.

syndrome and cancer. Int J Biol Sci. 7: 1003-15.

Am J Pathol. 169: 1505-22.

Mellitus. 579-99.

Mediation of nutrition and environmental stressors through hormonal and physiological responses alters growth performance and lipid metabolism in nonruminants, resulting in substantial impacts on carcass lipid quality. Understanding and managing the factors that control carcass fat quality is a challenge for the swine industry yet provides opportunities to improve final carcass quality and profitability of pork production. Three major contributors to lipid quality in swine are regulation of *de novo* lipogenesis, dietary lipid composition, and environmental stressors. This chapter will evaluate these contributors and their effects on lipid deposition and quality, as well as nutritional and managerial interventions.
