**Acknowledgement**

M. Kondrashova wish to keep alive the memory of the teachers in physiology and biochemistry Professors Iliya Arshavsky and Sergei Severin, whose influence helped her to find the own way in the area of these interdependent branches of biology.

The more than half a century correspondence with Britton Chance encouraged persistent attempts to fill the gap between isolated mitochondria and the organism.

The authors are indebted to Rodrigue Rossignol for mutual understanding and support of our line of investigations.

The authors are grateful to Dr. Polina Schwartsburd for the systematic valuable discussions on physiological regulation.

We are thankful to Dr. Fedor Kondrashov for creative editing the manuscript and Svetlana Sidorova for the help in translation.

This work was supported by the Federal target program "Investigations and elaborations of priority directions of scientific-technical complex of Russia for 2007-2012 (project no. 16.512.11.2117).

<sup>\*</sup> Corresponding Author
