**1. Introduction**

40 Dehydrogenases

[36] Kumar AP, Quake AL, Chang MK, Zhou T, Lim KS, Singh R, Hewitt RE, Salto-Tellez M, Pervaiz S, Clément MV (2009) Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor

cells in vitro and in vivo. Cancer Res. 69:8636-8644.

The problem of finding effective chemotherapies for advanced cancer remains largely unsolved. We review here the role of a specific class of central metabolic dehydrogenases whose regulatory properties are remodeled significantly in cancer cells. These remodeled properties may provide an attractive set of targets for the development of new chemotherapeutic drugs. The design features of the first agents to be developed attacking these new targets [1,2] may illustrate ways to exploit this potentially valuable therapeutic opportunity.
