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214 Injury and Skeletal Biomechanics

vulnerable to overuse injuries.

techniques used in tissue engineering.

*National University of Colombia, Colombia* 

*National University of Colombia, Colombia* 

Diego A. Garzón-Alvarado and Juan Carlos Vanegas-Acosta

**Author details** 

*Colombia*

Nancy S. Landínez-Parra

**Acknowledgement** 

to the financing the chapter.

**7. References** 

151, 513-538

If this pressure is maintained for prolonged periods dehydration of the tissue may result and cause changes in normal behavior, making it temporarily or permanently more sensitive to injury. These findings support the conclusion that a load consistently maintained for long periods of time or an excessive load that exceeds the characteristics of the tissue once it has reached the maximum possible displacement, can make one more

The data reported are the beginning of broader work in the study of cartilaginous tissues which can incorporate the cellular component differentially and cartilage's own biochemistry in the model. The results obtained motivate the efforts that currently seek to simulate the production and destruction of the matrix in the presence of mechanical loads, to simulate the restructuring of the same after an injury, to apply mathematical models in the study of cartilage growth and to study their behavior in vitro and in vivo. These lines of research aim to provide a solid foundation for the development of AC experiments *in vivo* and *in vitro* that expands the range of applications of numerical simulation techniques and

*Group of Mathematical Modeling and Numerical Methods GNUM-UN, Faculty of Engineering,* 

*Human Corporal Movement Department, Faculty of Medicine, National University of Colombia,* 

*Group of Mathematical Modeling and Numerical Methods GNUM-UN, Faculty of Engineering,* 

The authors wish to thank the Research Division of Bogota (DIB) of the National University of Colombia in the Call for Research for supporting this work under the project "Mathematical Modeling and Simulation of Processes in Mechanical and Biomedical Engineering" and Colciencias 2011 throughout the project "Model for the definition of term of the Layout of a manufacturing cell through set theory and optimization" who contributed

Almeida, E.S. & Spilker, R.L. (1998). Finite element formulations for hyperelasticbiphasic soft tissues transversely isotropic. *Computer methods in applied mechanics and engineering.*


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