**5. Summary**

The advances in ultrasound equipment and easy access to quantitative β-hCG have made the diagnosis of early ectopic pregnancies possible. The efforts to improve the management of ectopic pregnancy have also stimulated many investigators to design new approaches to treat early ectopic pregnancy. This enables successful application of conservative therapies such as local treatment of chemotherapeutic agents such as etoposide or methotrexate. Not like methotrexate, etoposide is not yet considered as a standard treatment for ectopic pregnancy while there are still no criteria established. As compared to local methotrexate treatment, local etoposide treatment has the advantages of better efficacy to treat patients with higher β-hCG level. With the aid of laparoscopic injection, local treatment of etoposide is considered as a precise localization and the minimally invasive option to the management of ectopic pregnancy.
