**Acknowledgement**

This paper is dedicated to Prof. Oei Ban Liang (1930-2010), the founder of the Inter-University Centre for Biotechnology, Bandung Institute of Technology, where most of the works presented in this chapter were carried out.

The work has been supported by Indonesian Ministry of Research and Technology (RUT 1993-1996 to S.S), Indonesian Ministry of National Education (HB 2000-2003 to W.T.I), Royal Netherlands Academy of Arts and Science (KNAW SPIN mobility program 2004 to S.S), Indonesian Toray Science Foundation (STRG 2006 to K.H.), and Institut Teknologi Bandung (RU-ITB 2007-present to D.N.). We thank Prof. J.J. Beintema (Rijks*universiteit* Groningen) for valuable advice and discussion.
