**3.4 Micromeritic properties**

Pure CAR could not pass through the funnel during the angle of repose experiment which could be due to the irregular shape and high fineness of the powder, which posed hurdles in the uniform flow from the funnel. It exhibited poor flowability and packability as indicated by Hausner ratio (1.52) and Carr's Index (34.37%). All agglomerates showed excellent flowability and packability (Angle of repose: 23-280; Carr's Index: 15-18%; Hausner ratio: 1.13-1.17) when compared to pure CAR. The improved flowability of agglomerates may be due to good sphericity and larger size of agglomerates. During the tapping process, smaller agglomerates might have infiltrated into the voids between larger particles, which could result improved packability (lower CI). The results of micromeritic properties are shown in Table 3.


aMean ± SD, n = 3; bSignificantly different compared to pure CAR (p<0.05).

Table 3. Micromeritics, Drug Content, Particle size, aqueous solubility data of carvedilol and its spherical crystals
