**1. Introduction**

58 Advances in Crystallization Processes

Yokota, M., Doki, N., & Shimizu, K. (2006). Chiral separation of a racemic compound

*International Edition*, Vol. 44, 3226-3229

*Growth & Design*, Vol. 6, No. 7, 1588-1590

the precipitation of the least stable β form of Glycine. *Angewandte Chemie* 

induced by transformation of racemic crystal structures: DL-Glutamic acid. *Crystal* 

Organic crystals have been utilized by organic chemists to identify materials by comparing melting point and mixed melting with known compounds, and to obtain pure materials by recrystallization. Furthermore, many attractive aspects of the crystals have been discovered since the latter half of the 1960's. For example, when organic molecules aggregate and form a crystal, a new property such as the electric conductivity or nonlinear optics characteristic develops by forming a peculiar arrangement style, and these crystals are used as electronic and optical materials. In addition, chemistry using the key information recorded in the molecule in the crystal has been developed. Molecular motion, which was cluttered with a variety of conformations in solution, is considerably controlled in the crystal, and molecules are arranged in a specific conformation depending on the closest-packing and molecular interactions in many cases. Therefore, a different molecular conformation will often be afforded in the crystal and in solution. In some cases, information for chirality recorded in the crystal is particularly interesting.1) Conglomerate crystals (racemic mixture) afforded from racemic compounds are also chiral crystals, which are used for preferential crystallization for optical resolution of racemate.2) On the other hand, compounds with unstable axial chirality, even in achiral in solution, may provide an axial chirality in a crystal where the molecular arrangement and molecular conformation are controlled. Using the chiral properties of the crystal, asymmetric synthesis without an external chiral source from achiral substrates has been studied by many research groups. This approach is also broadly recognized as an absolute asymmetric synthesis.

Since the 1970's, the combination of chiral crystallization and the solid-state photoreaction has provided many successful examples of absolute asymmetric synthesis.3) In these reactions, achiral materials adopted chiral arrangement only by spontaneous crystallization, and optically active products are obtained from the topochemically controlled reaction with high enantiomeric excesses (Figure 1).4) This method incurs a problem in the crystallization of achiral molecules in chiral space groups, albeit rare and unpredictable. However, in recent years, crystal engineering and the solid-state reaction to a variety of new systems has progressed to such an extent that it can now be regarded as an important branch of organic chemistry. Furthermore, some unique ideas involving solution chemistry utilizing the chiral crytals have also been developed. The achievement of an asymmetric synthesis starting from an achiral reagent and in the absence of any external chiral agent has long been an

Asymmetric Reaction Using Molecular Chirality Controlled by Spontaneous Crystallization 61

chirality in crystals as a source of chiral memory in solution (Figure 2).10) The provisional molecular chirality derived from chiral crystals can be effectively transferred to optically active products with various asymmetric reactions in fluid media. Two requirements must be met for asymmetric synthesis to become possible: chiral crystallization of the starting

If we can effectively use the chirality of the molecules expressed by spontaneous crystallization, asymmetric synthesis using chiral crystals, which has been restricted to the topochemical solid-state photoreaction, becomes a general synthetic method playing the part of organic synthesis.11) In this review, a general method of chiral crystallization and a new advanced asymmetric synthesis using the chiral crystals in a non-topochemical process

Fig. 2. Non-topochemical Asymmetric synthesis using chiral memory derived from the

chiral conformation in the crystal.

materials and slow racemization at a controlled temperature.

will be described.

intriguing challenge to chemists and is also central to the problem of the origin of optical activity on Earth.

We have designed many molecules suitable for intramolecular photochemical processes, and have reported the asymmetric photochemical reaction in the solid-state. Please refer to the literature because many reviews are provided about this reaction example.5)

Fig. 1. Absolute asymmetric synthesis using chiral crystals

However, this asymmetric synthesis has yet to be recognized as the peculiar example, and there are many issues to be resolved that play a part in synthetic organic chemistry. The greatest problem is the small ratio of substrates forming a chiral crystal, and its inability to adapt to all crystalline organic compounds. Another problem is only applicable to this technique for topochemical reaction. If the crystalline state is broken according to the progress of the reaction, molecular chirality in the crystal would disappear in an instant. Exceptionally, an asymmetric amplification reaction using a chiral crystal surface dialkylzinc developed by Soai yielded product of high optical purity.

Soai *et al*. reported the catalytic asymmetric automultiplication in the addition of the dialkylzinc reagents to pyrimidine aldehydes without decrease in the optical purity of the product. The 1,2-addition in the presence of a small amount of optically active material resulted in enhancement of the *ee* value in the product formation.6) The asymmetric reaction was widely spread to the use of chiral crystals as a chiral trigger. The reaction promoted on the surface of the crystal of quartz gave optically active carbonyl addition product in 97% *ee*. Furthermore, the reaction with chiral crystals of NaClO3, benzoylglycine, and cocrystals resulted in the formation of product with high *ee* value.

Håkansson *et al*. reported that two six-coordinate Grignard reagents crystallized as conglomerates and racemized rapidly in solution. Enantiopure Grignard reagents were reacted with butanal to give alcohol in up to 22% *ee*.7)

As the first example of asymmetric synthesis using chiral crystals involving solid-gas reaction,3a) some other interesting examples of solid-gas reaction using chiral crystals were reported. Reaction of chiral crystals of chalcone derivative with bromine in connection with rearrangement gave optically active dibromide in 8% *ee*.8)

Gerdil *et al*. reported two examples involving the solid-gas reactions of inclusion complexes of tri-*o*-thymonide with alkene or epoxycyclopentanone. The complex crystallized in a chiral fashion, and the reaction with singlet oxygen or hydrogen chloride gave products up to 22% *ee*.9)

The optical purity of the product was not satisfactory even in the reduced conversion rate of the reaction. To solve this problem, we explored a new methodology using molecular

intriguing challenge to chemists and is also central to the problem of the origin of optical

We have designed many molecules suitable for intramolecular photochemical processes, and have reported the asymmetric photochemical reaction in the solid-state. Please refer to

However, this asymmetric synthesis has yet to be recognized as the peculiar example, and there are many issues to be resolved that play a part in synthetic organic chemistry. The greatest problem is the small ratio of substrates forming a chiral crystal, and its inability to adapt to all crystalline organic compounds. Another problem is only applicable to this technique for topochemical reaction. If the crystalline state is broken according to the progress of the reaction, molecular chirality in the crystal would disappear in an instant. Exceptionally, an asymmetric amplification reaction using a chiral crystal surface

Soai *et al*. reported the catalytic asymmetric automultiplication in the addition of the dialkylzinc reagents to pyrimidine aldehydes without decrease in the optical purity of the product. The 1,2-addition in the presence of a small amount of optically active material resulted in enhancement of the *ee* value in the product formation.6) The asymmetric reaction was widely spread to the use of chiral crystals as a chiral trigger. The reaction promoted on the surface of the crystal of quartz gave optically active carbonyl addition product in 97% *ee*. Furthermore, the reaction with chiral crystals of NaClO3, benzoylglycine, and cocrystals

Håkansson *et al*. reported that two six-coordinate Grignard reagents crystallized as conglomerates and racemized rapidly in solution. Enantiopure Grignard reagents were

As the first example of asymmetric synthesis using chiral crystals involving solid-gas reaction,3a) some other interesting examples of solid-gas reaction using chiral crystals were reported. Reaction of chiral crystals of chalcone derivative with bromine in connection with

Gerdil *et al*. reported two examples involving the solid-gas reactions of inclusion complexes of tri-*o*-thymonide with alkene or epoxycyclopentanone. The complex crystallized in a chiral fashion, and the reaction with singlet oxygen or hydrogen chloride gave products up to

The optical purity of the product was not satisfactory even in the reduced conversion rate of the reaction. To solve this problem, we explored a new methodology using molecular

the literature because many reviews are provided about this reaction example.5)

Fig. 1. Absolute asymmetric synthesis using chiral crystals

resulted in the formation of product with high *ee* value.

reacted with butanal to give alcohol in up to 22% *ee*.7)

rearrangement gave optically active dibromide in 8% *ee*.8)

22% *ee*.9)

dialkylzinc developed by Soai yielded product of high optical purity.

activity on Earth.

chirality in crystals as a source of chiral memory in solution (Figure 2).10) The provisional molecular chirality derived from chiral crystals can be effectively transferred to optically active products with various asymmetric reactions in fluid media. Two requirements must be met for asymmetric synthesis to become possible: chiral crystallization of the starting materials and slow racemization at a controlled temperature.

If we can effectively use the chirality of the molecules expressed by spontaneous crystallization, asymmetric synthesis using chiral crystals, which has been restricted to the topochemical solid-state photoreaction, becomes a general synthetic method playing the part of organic synthesis.11) In this review, a general method of chiral crystallization and a new advanced asymmetric synthesis using the chiral crystals in a non-topochemical process will be described.

Fig. 2. Non-topochemical Asymmetric synthesis using chiral memory derived from the chiral conformation in the crystal.

Asymmetric Reaction Using Molecular Chirality Controlled by Spontaneous Crystallization 63

the molecules with the aromatic amide scaffold; this is because they can be synthesized many derivatives with variety substituents, and show considerable stability for the subsequent reaction. Molecules **1-4,** as shown in Figure 4, were designed to consider the development of subsequent asymmetric reactions. Imide **2** has an axial chirality based on the C-N bond; on the contrary, in compounds other than **2**, there is C-C bond axial chirality between the aromatic ring and amide groups. The racemization is inhibited to some extent by the steric repulsion between the aromatic ring and substituent on the amide nitrogen atoms of the planar structure. However, depending on the substituents on the aromatic ring and nitrogen atom, the rotational barrier of the N-C(=O) bond, except in special cases, is 20 ~ 24 kcal mol-1, and the bond can rotate slowly even at room temperature.14) In these substrates, when N-C(=O) bond rotation occurs, the racemization spontaneously proceeds depending on the Ar-(C=O) bond rotation; therefore, the maximum free energy of activation for racemization is also controllable. By changing the size and electronic property of the

substituents, we can finely tune the energy of racemization of the aromatic amide.

93% yield and with 80% *ee*.16)

N

R R

Ar

O

O

Ph

**2-benzoylbenzamides** 

N N Me

**1 2**

R1

R2

O

N

O

O Me O

Fig. 4. Achiral molecules with chiral memory effect

Ph

**5 6**

**4. Asymmetric reactions using chiral memory derived from chiral crystals 4.1 Asymmetric nucleophilic addition to carbonyl group using chiral crystals of** 

When 2-benzoyl benzamides **1a-d** with various sizes of substituents on the nitrogen atom were synthesized and the crystal structure was analyzed by X-ray crystallographic analysis,

Azumaya *et al*. also reported an example of retention of the molecular chirality when the chiral crystal of 1,2-bis(N-benzoyl-N-methylamino)benzene **5** was dissolved in cold CDCl3.15) The BIPHOS ligand **6** crystallizes as a conglomerate, and a single crystal in CH2Cl2 at -78°C reacts with [PdCl2(CH3CN)2] to give the enantiomerically pure complex [PdCl2(biphos)]. Tissot *et al*. reported an example of catalytic asymmetric synthesis where the enantiomerically pure complex was used in the catalytic asymmetric allylic substitution of 1,3-diphenylprop-2-enyl acetate with the anion of dimethyl malonate to give product in

> P P Ph Ph

Me Me Me Me

O N

OR ( )n

**3 4**

O

O

R1

N

R2

<sup>O</sup> R2
