**2.2.1 Drug content study**

The drug content study of agglomerates was determined by dissolving 100 mg of crystals in 3 ml methanol and diluting further with distilled water (100 ml) followed by measuring the absorbance of appropriately diluted solution spectrophotometrically (PharmaSpec UV-1700, UV-Vis spectrophotometer, Shimadzu) at 286 nm.
