**5. Antifungal treatment**

At the time of diagnosis and inclusion in this study, 122 case patients (12.3%) were receiving a systemic antifungal agent and were considered breakthrough infections (fluconazole, 78 patients, amphotericin B, 31 patients, itraconazole and voriconazole, 3 patient each; and echinocandins, 5 patients). Although the reason for this high rate of breakthrough infections is not clear, it is possible that other factors besides the antifungal resistance have got a role in the explanation of this phenomenon. A deep analysis of these 122 cases showed that either the antifungal therapy duration or the election of the antifungal drug was inadequate. A total of 536 case patients (54.5%) received antifungal therapy, started at a median of 3 days from the *Candida* isolation or onset of candidemia.
