**4. Conclusion**

The PID are congenital and inherited diseases that affect the immune system, which occurrence in population varies by type of study and study group. Recent studies indicate that these values in the general population are underestimated and are one of the biggest problems and lack of knowledge, both worldwide and Latin America. Many factors compromise its knowledge, such as lack of education centers, professional structure, and laboratory records. The incidence of PID in Latin America is similar to that observed in different parts of the world, with predominantly antibody defects. In Latin America, adds to these, the lack of government support and private initiative. To redress this problem was created LAGID, which hosts Latin American countries concerned with knowledge of incidence, diagnosis, treatment and discovery of new PID. For this, congresses are held, online records and establishing laboratory training, diagnosis and treatment of PID, based on the model established in Europe.
