of female

**7. References** 

**Note: Cross-generational reduction of females with pathogenic genes in the** 

Allen, N.C., Bagades, S., McQueen, M.B., Ioannidis, J.P.A., Kavvoura, F.K., Khoury, M.J., Tanzi, R.E. & Bertram, L. (2008). Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Schizophrenia: The SZGene Database. *Nat Genet*, Vol. 40, No. 7, (July 2008), pp. 827-834, ISSN 1061-4036

http://www.schizophreniaforum.org/res/szgene/default.asp


Impact of Epidemiology on Molecular Genetics of Schizophrenia 133

El-Saadi, O., Pedersen, C.B., McNeil, T.F., Saha, S., Welham, J., O'Callaghan, E., Cantor-

*Schizophr Res*, Vol. 67, No. 2-3, (April 2004), pp. 227-236, ISSN 0920-9964 Erlenmeyer-Kimling, L. (1968). Mortality rates in the offspring of schizophrenic parents and

Esposito, L.A., Melov, S., Panov, A., Cottrell, B.A. & Wallace, D.C. (1999). Mitochondrial

Fãnanás, L. & Bertranpetit, J. (1995). Reproductive rates in families of schizophrenic patients

Finkel, T. (2003). Oxidant signals and oxidant stress. *Curr Opin Cell Biol*, Vol. 15, No.2 , (Apr

Folgero, T., Storbakk, N., Torbergsen, T. & Oian, P. (1996). Mutations in mitochondrial

Furui, T., Kurauchi, O., Tanaka, M., Mizutani, .S, Ozawa, T. & Tomoda, Y. (1994). Decrease

Goldstein, J.M., Faraone, S.V. & Chen, W.J., Tolomiczencko, G.S. & Tsuang, M.T. (1990). Sex

Goldstein, J.M. & Lewine, R.R.J. (2000). Overview of sex differences in schizophrenia: where

Gottesman, I.I. & Bertelsen, A. (1989). Confirming unexpressed genotypes for schizophrenia.

Gupta, P., Narang, M., Banerjee, B.D. & Basu, S. (2004). Oxidative stress in term small for

Harrison, G., Cooper, J.E. & Gancarczyk, R. (1991). Changes in the administrative incidence of

Haukka, J., Suvisaari, J., & Lonnqvist, J. (2003). Fertility of patients with schizophrenia, their

He, L., Perkins, G.A., Poblenz, A.T., Harris, J.B., Hung, M., Ellisman, M.H. & Fox, D.A.

*Am J Psychiatry*, Vol. 160, No. 3, (Mar 2003), pp. 460-463, ISSN 0002-953X Hayashi, M. (1950). A study of schizophrenia. (in Japanese) *Psychiatr Neurol Japonica*, Vol. 51,

*BMC Pediatrics*, Vol. 4, No. 4, (July 2004), pp. 14-20, ISSN 1471-2431

96, No. 9, (Apr 1999), pp. 4820-4825, ISSN 0027-8424

800, ISSN 0028-0836

ISSN 1600-0447

ISSN 0029-7844

978-0521786171, Cambridge

ISBN 978-0716721475, New York, NY

No. 3, (Mar 1950), pp.193-245, ISSN 0033-2658

2003), pp. 247-254, ISSN 0955-0674

(May 1996), pp. 1626-1630, ISSN 0002-9378

No. 6, (Jun 1990), pp. 819-826, ISSN 0007-1250

Graae, E., Chant, D., Mortensen, P.B. & McGrath, J. (2004). Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia.

a physiological advantage hypothesis. *Nature*, Vol. 5169, 220, (Nov 1968), pp. 798-

disease in mouse results in increased oxidative stress. *Proc Natl Acad Sci USA*, Vol.

in a case-control study. *Acta Psychiatr Scand*, Vol. 91, No. 3, (Mar 1995), pp. 202-204,

transfer ribonucleic acid genes in preeclampsia. *Am J Obstet Gynecol*, Vol. 174, No. 5,

in cytochrome c oxidase and cytochrome oxidase subunit I messenger RNA levels in preeclamptic pregnancies. *Obstet Gynecol*, Vol. 84, No. 2, (Aug 1994), 283-288,

differences in the familial transmission of schizophrenia. *Br J Psychiatry*, Vol. 156,

have we been and where do we go from? In: *Women and schizophrenia*, Castle, D.L., McGrath, J. & Kulkarni, J. eds., pp. 111-143, Cambridge University Press, ISBN

Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. *Arch Gen Psychiatry*, Vol. 46, No. 10, (Oct 1989), pp. 867-872, ISSN 0003-990X Gottesman, I.I. (1991). *Schizophrenia Genesis; The Origin of Madness.* Freeman & Company,

gestational age neonates born to undernourished mothers: a case controlled study.

schizophrenia. *Br J Psychiatry*, Vol. 159, No. 6, (Dec 1991), pp. 811-816, ISSN 0007-1250

siblings, and the general population: a cohort study from 1950 to 1959 in Finland.

(2003). Bcl-xL overexpression blocks bax-mediated mitochoncrial contact site


Brüne, M. (2004). Schizophrenia - an evolutionary enigma? *Neurosci Biobehav Rev*, Vol. 28,

Bundy, H., Stahl, D. & McCabe, J.H. (2011). A systemic review and meta-analysis of the

Byrne, M., Agerbo, E., Ewald, H., Eaton, W.W. & Mortensen, P.B. (2003). Parental age risk of

Cannon, T.D., Kaprio, J., Lönnqvist, .J, Huttunen, M. & Koskenvuo, M. (1998). The genetic

study. *Arch Gen Psychiatry*, Vol. 55, No. 1, (Jan 1998), pp. 67-74, ISSN 0003-990X Cannon, M., Jones, P.B. & Murray, R.M. (2002).Obstetric complications and schizophrenia:

Cardno, A.G., Marshall, E.J., Coid, B., Macdonald, A.M., Ribchester, T.R., Davies, N.J.,

Chang, C.M., Yu, C.C., Lu, H.T., Chou, Y.F. & Huang, R.F. (2007). Folate deprivation

rat liver. *Br J Nutr*, Vol. 97, No. 5, (May 2007), pp. 855-863, ISSN 0007-1145 Chen, J.Q., Delannoy, M., Cooke, C. & Yager, J.D. (2004). Mitochondrial localization of

Crepsi, B., Summers, K., Dorus, S. (2007). Adaptive evolution of genes underlying

Crow, T.J. (1995). A Darwinian approach to the origin of psychosis. *Brit J Psychiatry*, Vol.

Dalman, C., Allebeck, P., Gunnell, D., Harrison, G., Kristensson, K., Lewis, G., Lofving, S.,

Dalman, C., Allebeck, P., Cullberg, J., Grunewald, C. & Köster, M. (1999). Obstetric

view point. *PLoS One*, Vol. 4, No.11, (Nov 2009), e7799, ISSN 1932-6203 Edlund, C., Holmberg, K., Dallnen, G., Norrby, E. & Kristensson, K. (1994). Ubiquinone-10

*Scand*, Vol. 123, No. 2, (Feb 2011), pp. 98-106, ISSN 1600-0447

fertility of patients with schizophrenia and their unaffected relatives. *Acta Psychiatr* 

schizophrenia. A case-control study. *Arch Gen Psychiatry*, Vol. 60, No. 7, (Jul 2003),

epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling

historical and meta-analytic review. *Am J Psychiatry*, Vol. 159, No. 7, (July 2002), pp.

Venturi, P., Jones, L.A., Lewis, S.W., Sham, P.C., Gottesman, I.I., Farmer, A.E., McGuffin, P., Reveley, A.M. & Murray, R.M. (1999). Heritability estimates for psychotic disorders. Maudsley twin psychosis series. *Arch Gen Psychiatry*, Vol. 56,

promotes mitochondrial oxidative decay : DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarisation and superoxide overproduction in

ERalpha and ERbeta in human MCF7 cells. *Am J Physiol Endocrinol Metab*, Vol. 286,

schizophrenia. *Proc R Soc B* 2007, Vol. 274, No. 1627, (Nov 2007), pp. 2801-2810,

Rasmussen, F., Wicks, S. & Karlsson, H. (2008). Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects. *Am J Psychiatry*, Vol. 165, No. 1, (Jan 2008), pp. 59-65,

complications and the risk of schizophrenia. A longitudinal study of a national birth cohort. *Arch Gen Psychiatry*, Vo. 56, No. 3, (Mar 1999), pp. 234-240, ISSN 0003-990X Demirhan, O., Tastemir, D. & Sertdemir, Y. (2006). Chromosomal fragile sites in schizophrenic patients. *Genetika*, Vol. 42, No. 7, (July 2006), pp. 985-92, ISSN 0016-6758 Doi, N., Hoshi, Y., Itokawa, M., Usui, C., Yoshikawa, T., & Tachikawa, H. (2009). Persistence

criteria for susceptibility genes for schizophrenia – a discussion from an evolutionary

protects neurons from virus-induced degenerations. *J Neurochem*, Vol. 63, No. 2,

No. 1, (Mar 2004), pp. 41-53, ISSN 0149-7634

No.2 , (Feb 1999), pp. 162-168, ISSN 0003-990X

No. 6, (Jun 2004), E1011-E1022, ISSN 0193-1849

167, No. 1, (July 1995), pp. 12-25, ISSN 0007-1250

(Aug 1994), pp. 634-639, ISSN 1471-4159

pp. 673-678, ISSN 0003-990X

1080-1092, ISSN 0002-953X

ISSN 1471-2954

ISSN 0002-953X


Impact of Epidemiology on Molecular Genetics of Schizophrenia 135

Marchbanks, R.M., Mulcrone, J. & Whatley, S.A. (1995) Aspects of oxidative metabolism in

McGrath, J.J., Hearle, J., Jenner, L., Plant, K., Drummond, A. & Barkla, J.M. (1999). The

McGrath, J., Saha, S., Chant, D. & Welham, J. (2008). Schizophrenia: A concise overview of

McGue, M. & Gottesman, I.I. (1991). The genetic epidemiology of schizophrenia and the

Modrzewska, K. (1980). The offspring of schizophrenic parents in a North Swedish isolate.

Monje, P. & Boland, R. (2001). Subcellular distribution of native estrogen receptor alpha and

Murphy, K.C., Jones, L.A. & Owen, M.J. (1999). High rates of schizophrenia in adults with

Nachman, M.W. & Crowell, S.L. (2000). Estimate of the mutation rate per nucleotide in humans. *Genetics*, Vol. 156, No. 3, (Sept 2000), pp. 297-304, , ISSN 0016-6731 Nanko, S. & Moridaira, J. (1993). Reproductive rates in schizophrenic outpatients. *Acta Psychiatr Scand*, Vol. 87, No. 6, (Jun 1993), pp. 400-404, ISSN 1600-0447 Need, A.C., Ge, D., Weale, M.E., Maia, J., Feng, S., Heinzen, E.L., Shianna, K.V., Yoon, W.,

Schizophrenia. *PLoS Genet* Vol. 5, No. 2, (Feb 2009), e1000373, ISSN 1553-7404 Nimgaonkar, V.L. (1998). Reduced fertility in schizophrenia: here to stay? *Acta Psychiatr* 

Nishikawa, Y., Kawase, O., Vielemeyer, O., Suzuki, H., Joiner, K.A., Xuan, X. & Nagasawa,

Ohashi, J & Tokunaga, K. (2002). The expected power of genome-wide linkage

Ødegård, Ø. (1980). Fertility of psychiatric first admissions in Norway, 1936-1975. *Acta Psychiatr Scand*, Vol. 62, No. 3, (Sep 1980), pp. 212-220, ISSN 1600-0447 Oken, R.J. & Schulzer, M. (1999). At issue: schizophrenia and rheumatoid arthritis: the

H. (2007). Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors. *Parasite Immunol*, Vol.

disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant. *Ann Hum Genet*, Vol. 66, No. 4, (July 2002), pp.

negative association revised. *Schizophr Bull*, Vol. 25, No.4 , (Oct 1999), pp. 625-638,

*Scand*, Vol. 98, No. 5, (Nov 1998), pp. 348-353, ISSN 1600-0447

29, No. 7, (July 2007), pp.375-385, ISSN 0141-9838

*Clin Genet*, Vol. 17, No. 3. (Mar 1980), pp. 191-201, ISSN 1399-0004

0007-1250

6, (Jun 1999), pp. 441-446, ISSN 1600-0447

2008), pp. 67-76, ISSN 0193-936X

1991), pp. 174-181, ISSN 0940-1334

pp. 467-479, ISSN 1097-4644

940-945, ISSN 0003-990X

297-306, ISSN 0003-4800

ISSN 0586-7614

schizophrenia. *Brit J Psychiatry*, (1995), Vol. 167, No. 3, (Sep 1995), pp.293-298, ISSN

fertility and fecundity of patients with psychoses. *Acta Psychiatr Scand*, Vol. 99, No.

incidence, prevalence, and mortality. *Epidemiologic Reviews*, Vol. 30, No. 1, (Nov

design of linkage studies. *Eur Arch Psychiatry Clin Neurosci*, Vol. 240, No. 3, (Feb

beta isoforms in rabbit uterus and ovary. *J Cell Biochem*, Vol. 82, No. 3, (Sep 2001),

velo-cardio-facial syndrome. *Arch Gen Psychiatry*, Vol. 56, No. 10, (Oct 1999), pp.

Kasperaviciūte, D., Gennarelli, M., Strittmatter, W.J., Bonvicini, C., Rossi, G., Jayathilake, K., Cola, P.A., McEvoy, J.P., Keefe, R.S., Fisher, E.M., St Jean, P.L., Giegling, .I, Hartmann, A.M., Möller, H.J., Ruppert, A., Fraser, G., Crombie, C., Middleton, L.T., St Clair, D., Roses, A.D., Muglia, P., Francks, C., Rujescu, D., Meltzer, H.Y. & Goldstein, D.B. (2009). A Genome-Wide Investigation of SNPs and CNVs in

formation and apoptosis in rod photoreceptors of lead-exposed mice. *Proc Natl Acd Sci USA*, Vol. 100, No. 3, (Feb 2003), pp. 1022-1027, ISSN 0027-8424


Hitchon, C.A. & El-Gabalawy, H.S. (2004). Oxidation in rheumatoid arthritis. *Arthritis Res* 

Hussain, S.P., Hofseth, L.J. & Harris, C.C. (2003). Radical causes of cancer. *Nat Rev Cancer*,

Huxley, J., Mayr, E., Osmond, H. & Hoffer, A. (1964). Schizophrenia as a genetic morphism.

Jablensky, A.V. (1995). Schizophrenia: the Epidemiological Horizon. In: *Schizophrenia* Hirsch,

Keller, M.C. & Miller, G. (2006). Resolving the paradox of common, harmful, heritable

Kendler, K.S. & Dichl, S.R. (1993). The genetics of schizophrenia: a current, genetic-

Kinney, D.K., Richards, R., Lowing, P.A., LeBranc, D., Morris, E., Zimbalist, M.E., & Harlan, P.

Kruman, I.I., Culmsee, C., Chan, S.L., Kruman, Y., Guo, Z., Penix, L. & Mattson, M.P. (2006).

Kulkarni, J. & Fink, G. (2000). Hormones and psychosis. In: *Women and schizophrenia*, Castle,

Larson, C.A. & Nyman, G.E. (1973). Differential fertility in schizophrenia. *Acta Psychiatr* 

Limosin, F., Rouillon, F., Payan, C., Cohen, J-M. & Strub, N. (2003). Prenatal exposure to

Li, X., Sundquist, J. & Sundquist, K. (2007). Age-specific familial risks of psychotic disorders

Lo, W.S., Xu, Z., Yu, Z., Pun, F.W., Ng, S.K., Chen, J., Tong, K.L., Zhao, C., Xu, X., Tsang,

Macintyre, D.J., Blackwood, D.H.R., Porteous, D.J., Pickard, B.S. & Muir, W.J. (2003).

Malaspina, D., Harlap, S., Fennig, S., Heiman, D., Nahon, D., Feldman, D. & Susser, E.S.

S.R. & Weinberger, D.R., eds., pp. 206-252, Blackwell Science, ISBN 0-632-03276-6,

mental disorders: Which evolutionary genetic models work best? *Behav Brain Sci*,

epidemiologic perspective. *Schizophr Bulletin*, Vol. 19, No. 2, (Apr 1993), pp. 261-285

(2001). Creativity in offspring of schizophrenic and control parents: an adoption study. *Creativity Research Journal*, Vol. 13, No. 1, (Jan 2001), pp.17-25, ISSN 1532-6934 Kirov, G., O'Donovan, M.C., Owen, M.J. (2005). Finding schizophrenia genes. *J Clin Invest*,

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. *J Neurosci*, Vol. 20, No. 18, (Sep 2006), pp.

D.L., McGrath, J. & Kulkarni, J. eds., pp. 51-66, Cambridge University Press, ISBN

influenza as a risk factor for adult schizophrenia. *Acta Psychiatr Scand*, Vol. 107, No.

and schizophrenia: a nation-wide epidemiological study from Sweden. *Schizophr* 

S.Y., Harano, M., Stöber, G., Nimgaonkar, V.L., & Xue, H. (2007). Positive selection within the schizophrenia-associated GABAA receptor β2 gene. *PLoS One*, Vol. 2, No.

Chromosomal abnormalities and mental illness. *Mol Psychiatry*, Vol. 8, No. 3, (Mar

(2001). Advancing paternal age and the risk of schizophrenia. *Arch Gen Psychiatry*,

*Sci USA*, Vol. 100, No. 3, (Feb 2003), pp. 1022-1027, ISSN 0027-8424

*Nature*, Vol. 204, No. 4955, (Oct 1964), pp. 220-221, ISSN 0028-0836

*Ther*,Vol. 6, No. 6, (Oct 2004), pp. 265-278, ISSN 1473-6362

Vol. 3, No. 4, (Apr 2003), pp. 276-285, ISSN 1474-175X

Vol. 29, No. 4, (Aug 2006), pp. 385-404, ISSN 0140-525X

Vol. 115, No. 6, (Jun 2005), pp. 1440-1448, ISSN 0021-9738

*Scand*, Vol. 49, No. 3, (Jun 1973), pp. 272-280, ISSN 1600-0447

*Res*, Vol. 97, No. 1-3, (Dec 2007), pp. 43-50, ISSN 0920-9964

Vol. 58, No. 4, (Apr 2001), pp. 361-367, ISSN 0003-990X

London

ISSN 0586-7614

6920-6026, ISSN 1529-2401

978-0521786171, Cambridge

5, (May 2003), pp. 331-335, ISSN 1600-0447

5, (May 2007), e462, ISSN 1932-6203

2003), pp. 275-287, ISSN 1359-4184

formation and apoptosis in rod photoreceptors of lead-exposed mice. *Proc Natl Acd* 


Impact of Epidemiology on Molecular Genetics of Schizophrenia 137

Samper, E., Nicholls, D.G. & Melov, S. (2003). Mitochondrial oxidative stress causes

Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H.,

Shanklin, D.R., Sibai, B.M. (1990). Ultrastructural aspects of preeclampsia. II. Mitochondrial

Shimizu, A., Kurachi, M., Yamaguchi, N., Torii, H. & Isaki K. (1987). Morbidity risk of

Sigurđardóttir, S., Helgason, A., Gulcher, J.R., Stefansson, K. & Donnely, P. (2000). The

Sipos, A., Rasmussen, F., Harrison, G., Tynelius, P., Lewis, G., Leon, D.A. & Gunnell, D.

Smith, C.L., Bolton, A. & Nguyen, G. (2010). Genomic and epigenomic instability, fragile

Sobel, D. E. (1961). Infant mortality and malformations in children of schizophrenic women.

Speir, E., Yu, Z.X., Ferrans, V.J., Huang, E.S. & Epstein, S.E. (1998). Aspirin attenuates

Stabeneau, J.R., Pullin, W., Moshe, R.L.R., Froman, C., Friedhoff, A.J., & Turner, W. (1969).

*Arch Gen Psychiatry*, Vol. 20, No. 2, (Feb 1969), pp. 145-158, ISSN 0003-990X Stirone, C., Duckles, S.P., Krause, D.N. & Procaccio, V. (2005). Estrogen increases

Strehlow, K., Rotter, S., Wassmann, S., Adam, O., Grohé, C., Laufs, K., Böhm, M. &

estrogen. *Circ Res*, Vol. 93, No. 2, (July 2003), pp. 170-173, ISSN 0009-7330 Susser, E., Neugebauer, R., Hoek, H.W., Brown, A.S., Lin, S., Labovitz, D. & Gorman, J.M.

Svensson, A.C., Lichtenstein, P., Sandin, S. & Hultman, C.M. (2007). Fertility of first-degree

*Psychiatr Q*, Vol. 35, No. 1, (Mar 1961), pp. 60-65, ISSN 0033-2720

*Pharmacol*, Vol. 68, No. 4, (Oct 2005), pp.959-965, ISSN 0026-895X

Vol. 53, No. 1, (Jan 1996), pp. 25-31, ISSN 0003-990X

*Res*, Vol. 91, No. 1-3, (Mar 2007), pp. 238-245, ISSN 0920-9964

*Neurol*, Vol. 41,No. 1, (Mar 1987), pp. 65-70, ISSN 0912-2036

(Oct 2003), pp. 277-285, ISSN 1474-9718

(May2000), pp. 1599-1609, ISSN 0002-9297

6; 329(7474):1070. Epub 2004 Oct 22, ISSN 1468-5833

41553-41558, ISSN 0021-9258

447-469, ISSN 1389-2029

216, ISSN 0009-7330

9378

chromosomal instability of mouse embryonic fibroblasts. *Aging Cell*, Vol. 2, No. 5,

Hartman, P.S. & Ishii, N. (2001). A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in *Caenorhabditis elegans*. *J Biol Chem*, Vol. 276, No. 45, (Nov 2001), pp.

changes. *Am J Obstet Gynecol*, Vol. 163, No. 3, (Sep 1990), pp.943-953, ISSN 0002-

schizophrenia to parents and siblings of schizophrenic patients. *Jpn J Psychiatry* 

mutation rate in the human mtDNA control region. *Am J Hum Genet*, Vol. 66, No. 5,

(2004). Paternal age and schizophrenia; a population based cohort study. *BMJ*, Nov

sites, schizophrenia and autism. *Current Genomics*, Vol. 11, No. 6, (Sep 2010), pp.

cytomegalovirus infectivity and gene expression mediated by cyclooxigenase-2 in coronary artery smooth muscle cells. *Circ Res*, Vol. 83, No. 2, (July 1998), pp. 210-

Study of monozygotic twins discordant for schizophrenia. Some biologic variables.

mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. *Mol* 

Nickenig, G. (2003). Modulation of antioxidant enzyme expression and function by

(1996). Schizophrenia after prenatal famine. Further evidence. *Arch Gen Psychiatry*,

relatives of patients with schizophrenia: A three generation perspective. *Schizophr* 


Opler, M.G.A. & Susser, E.S. (2005). Fetal environment and schizophrenia. *Environment Health Perspectives*, Vol. 113, No. 9, (Sep 2005), pp. 1239-1242, ISSN 0091-6765 Osby, U., Hammer, N., Brandt, L., Wicks, S., Thinsz, Z., Ekbom A, Sparén P. (2001). Time

Pajović, S.B., Saićić, Z.S., Spasić, M.B. & Petrović, V.M. (2003).The effect of ovarian hormones

Poncet, D., Pauleau, A.L., Szabadkai, G., Vozza, A., Scholz, S.R., Le Bras, M., Brière, J.J., Jalil,

Prabakaran, S., Swatton, J.E., Ryan, M.M., Huffaker, S.J., Huang, J.T-J., Griffin, J.L., Wayland,

Pulver, A.E., Nestadt, G., Goldberg, R., Shprintzen, R.J., Lamacz, M., Wolyniec, P.S.,

Rapoport, J.L., Addington, A.M. & Fragnau, S. (2005). The neurodevelopmental model of

Remans, P.H., van Oosterhout, M., Smeets, T.J., Sanders, M., Frederiks, W.M., Reedquist,

Risch, N., Reich, E.W., Wishnick, M.M. & McCarthy, J.G. (1987). Spontaneous mutation and

Rubinstein, G. (1997). Schizophrenia, rheumatoid arthritis and natural resistance genes. *Schizophr Res*, Vol. 25, No. 3, (Jun 1997), pp. 177-181, ISSN 0920-9964

(Mar2003), pp. 189-194, ISSN 0826-8404

9964

996, ISSN 0021-9525

684-697, ISSN 1359-4184

pp. 9747-9752, ISSN 0027-8424

1975), pp. 200-211, ISSN 0003-990X

ISSN 1359-4184

ISSN 0002-9297

trends in first admissions for schizophrenia and paranoid psychosis in Stockholm County, Sweden. *Schizophr Res*, Vol. 47, No. 2-3, (Mar 2001), pp. 247-254, ISSN 0920-

on antioxidant enzyme activities in the brain of male rats. *Physiol Res*, Vol. 52, No. 2,

A., Le Moigne, R., Brenner, C., Hahn, G., Wittig, I., Schägger, H., Lemaire, C., Bianchi, K., Souquère, S., Pierron, G., Rustin, P,. Goldmacher, V.S., Rizzuto, R., Palmieri, F. & Kroemer G. (2006). Cytopathic effects of cytomegalovirus-encoded apoptosis inhibitory protein vMIA. *J Cell Biol*, Vol. 174, No. 7, (Sep 2006), pp. 985-

M., Freeman, T., Dudbridge, F., Lilley, K.S., Karp, N.A., Hester, S., Tkachev, D., Mimmack, L., Yolken, R.H., Webster, M.J., Torrey, E.F., & Bahn, S. (2004). Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. *Molecular Psychiatry*, Vol. 9, No. 7, (July 2004), pp.

Morrow, B., Karayiorgou, M., Antonarakis, S.E., Housman, D. et al. (1994). Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. *J Nerv Ment Dis*, Vol. 182, No. 8, (Aug 1994), pp. 476-478, ISSN 0022-3018 Ragu, S., Faye, G., Iraqui, I., Masurel-Heneman, A., Kolodner, R.D. & Huang, M-E. (2007).

Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death. *Proc Natl Acad Sci USA*, Vol. 104, No. 23, (Jun 2007),

schizophrenia: update 2005. *Mol Psychiatry*, Vol. 10, No. 5, (May 2005), pp. 434-449,

K.A., Tak, P.P., Breedveld, F.C. & van Laar, J.M. (2005). Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. *Arthritis & Rheumatism*, Vol. 52, No. 7, (July 2005), pp. 2003-2009, ISSN 0004-3591 Rieder, R.O., Rosenthal, D., Wender, P. & Blumenthal, H. (1975). The offspring of

schizophrenics, I: fetal and neonatal deaths. *Arch Gen Psychiatry*, Vol. 32, No. 2, (Feb

parental age in humans. *Am J Hum Genet*, Vol. 41, No. 2, (Aug 1987), pp.218-248,


**8** 

Kuschel Annett

*Germany* 

*Humboldt Universität zu Berlin* 

**The Epidemiology of Child Psychopathology:** 

Epidemiological information is needed for developing public policies to improve children's mental health. In particular, epidemiological research could provide answers to questions such as 1) How many children in the community have mental health problems; 2) What is the distribution of mental health problems across age, sex, levels of socio-economic status, and neighbourhood disadvantage; 3) What is the information about mental health problems from different informants (parents, teachers, and the child); and 4) What is the developmental course of mental health problems in childhood (Costello & Angold, 2006)? Answers to such questions may assist policy-makers and clinicians in designing strategies

After briefly explaining epidemiological concepts and strategies, a selective review of epidemiological research relevant to child mental health policies is given. The purpose of the second part of this chapter is to report on results of two studies. The studies were performed in order to assess the prevalence of emotional and behavioural problems from different informants, to investigate factors which may be associated with prevalence, and to determine the prevalence and incidence rates of ADHD and ODD from preschool to primary school. Of additional concern was the developmental course of externalizing behaviour problems. Finally, the implication of the epidemiological outcomes for future

The epidemiology of childhood psychopathology includes the following aims (Costello &





of psychological symptoms in different population groups and regions,

**1. Introduction**

Angold, 1995):

disorders,

for improving mental health in children.

research and mental health services are discussed.

**2. Aims of epidemiological research** 

in different population groups,

interference from mental disorders,

**Basic Principles and Research Data** 

