*6.1.1.2.1 Benzyl penicillin (crystallized penicillin G)*

The antibacterial spectrum is limited. It cannot be administered by oral route as it is decomposed in gastric acid and is not well-absorbed by digestive tract (Rang et al, 1998; Dökmeci 2000).

Newborn: IV 15-30 min. 6 dose/day every 4 hours established optimal treatment. Newborn: <2000g: 50.000 U/kg/day (every 12 hours) In Meningitis: 100.000 U/kg/day (every 12 hours) Newborn: >2000g: 75.000 U/kg/day (every 12 hours) In Meningitis: 150.000 U/kg/day (every 12 hours) Infant (I), child (C): 100.000-250.000 U/kg/day (every 4-6 hours) In Serious Infections: 200-400.000 U/kg/day (every 4-6 hours) Higher doses are required in B group streptococcal meningitis (Apak, 1996). *Side effects* are as follows: allergy, shock, anaphylaxis, serum disease, rash, gastrointestinal system (GIS) (Eroğlu, 2002).
