**6.1.6 Macrolides**

310 Complementary Pediatrics

*Incompatible Drugs:* Amphotericin B, Ampicillin, Furosemide, Heparin (>1 U/ml), Imipenem/Cilastatin, Indomethacin, Methicillin, Mezlocillin, Nafcillin, Oxacillin, Penicillin

It is an antibiotic and anti-tuberculostatic drug. It affects some gram negative and positive microorganisms (Kavakl et al, 1998). It is used with Isoniazid and other tuberculosis drugs in tuberculosis meningitis and progressive tuberculosis. In tuberculosis meningitis it is administered by IM route every 12 hours 20-40 mg/kg/day. The maximum dose is 1 g/day. The length of treatment period is usually 2-3 months. Higher doses and/or more prolonged

*Side effects:* Myocarditis, Ataxia, nuisance, vomiting, ototoxicity, nephrotoxicity and

It is more active against P. Aeruginosa than gentamycin. Newborn; IV (30-60 min.) , IM; <7 days <34 weeks <1500g; 3 mg/kg every 24 hours, >1500g; 2.5 mg/kg every 18 hours, >34 weeks >1500g; 2.5 mg/kg every 12 hours, >after 7 days; 5 mg/kg every 12 hours, for older

Treatment of infections caused by aerobic gram-negative bacilli (Young & Mangum, 2010). It is antimicrobial effective and indicated for the treatment of sepsis caused by susceptible E. *coli, Klebsiella, Enterobacter, Pseudomonas, H. influenza, Salmonella, Shigella, Staphylococci* and of respiratory tract and surgical infections. And it is used in the treatment of complicated urinary system infections, sepsis, skin and skin joint infections, lower respiratory infections

*Uses:* Serious life-threatening infections with bacteria sensitive to Netromycin (sepsis,

The dose to be used in the first week ≤29 gestational weeks 5 mg/kg/dose every 48 hours

After the first week 4 mg/kg is administered as first dose. After 12-24 hours following the end of infusion the dose interval is calculated on the basis of serum concentration (Kanmaz,

30-33 weeks 4.5 mg/kg/dose every 48 hours

34-37 weeks 4 mg/kg/dose every 36 hours

≥38 weeks 4 mg/kg/dose every 24 hours

*Dose:* The dose to be used in the first week ≤29 gestational weeks 5 mg/kg/dose every 48

people; 5-7.5 mg/kg/day IM, IV every 6-8 hours (Eroğlu, 2002; Küçüködük, 1994).

G, Propofol, Cefepime, Ticarcillin/Clavulanate (Kanmaz, 2010).

therapy may result to destruction in 8th cranial nerve (Eroğlu, 2002).

hypersensitivity can be seen (Kavakl et al, 1998).

and intra-abdominal infections (Köksal & Mangum, 2010).

endocarditis) (Young & Mangum, 2010).

**6.1.5.3 Streptomycin sulfate** 

**6.1.5.4 tobramycin** 

**6.1.5.5 Netilmicin** 

2010).
