**6.3.2 Fluconazole**

314 Complementary Pediatrics

disseminated or CNS infections for 21 days (Young & Mangum, 2010).As this drug's intestinal absorption is not that good it should be taken by oral route at high doses. The drug reaches its peak after 1.5-2 hours following being administered by oral route. Almost

*Adverse Effects:* The most common side effects are nausea, vomiting, diarrhea and headache. Other reported side effects include agitation, confusion, rash, anemia, and muscle pain. Hypersensitivity reactions, seizures, agitation, confusion, anemia, hepatitis, and muscle pain

*The things to be considered by nurse applying the drug:* In application by IV route a vial of 500 mg is diluted with 10 ml sterile water. The vial is shaken until the drug is fully dissolved. The desired dose is taken into syringe. In order to decrease concentration a single dose should be administered every 1 hour with infusion solution and if possible with infusion pump. Fast application may result in phlebitis and kidney destruction. The infusion area should be changed in order to avoid thrombophlebitis. The prepared solution should be

As the drug gets discharged from urinary system the child should be provided with adequate hydration pre-application and during application. The nephrotoxicity risk

Nurse should attentively observe the observable side effects of the drug and should notify doctor if any is observed. If necessary, drug use should be ceased at once (Kavakl et al, 1998).

It is an antiviral drug used for the prevention of hearing loss in infants with symptomatic

Children; first line treatment, 10 mg/kg/day IV (1 hour, slow) every 8-12 hours, 14-21 days; Maintenance, 5-6 mg/kg/day IV every 12-24 hours for 5 days in a week (Dökmeci, 2001). The dose should be halved in case of a serious neutropenia (<500/mm3) (Kanmaz, 2010).

*Incompatible Drugs:* Enalaprilat, Fluconazole, Linezolid, Propofol, Remifentanil, Aztreonam,

These composites produced by body cells against viral infections can be synthesized via recombinant DNA technology in our day. The activities of these substances in the treatment

It destroys the cell membrane permeability. It is used in progressive and fatal infections as a

have also been reported (Apak, 1996; Kavakl et al, 1998; Young & Mangum, 2010).

30-90% of it is discharged by urinary system (Kavakl et al, 1998).

decreases after 2 hours following infusion application.

congenital CMV infection (Dökmeci, 2001; Kanmaz, 2010).

Cefepime, Piperacillin-Tazobactam (Kanmaz, 2010).

of virus infections are a matter of research (Biçer, 2008).

result of toxicity (Apak, 1996; Dökmeci, 2001; Eroğlu, 2002).

*Side Effects:* Granulocytopenia, anemia, thrombocytopenia (Kanmaz, 2010).

used within 12 hours.

**6.2.2 Gansklovir** 

**6.2.3 Interferons** 

**6.3 Antifungal drugs** 

**6.3.1 Amphotericin B liposome** 

It is active against oropharynx, esophagus, urinary and systemic candidiasis. It is orally well- absorbed. It interacts with Warfarin, Phenytoin, Cyclosporine and Rifampin (Eroğlu, 2002).
