**6.2.3 Interferons**

These composites produced by body cells against viral infections can be synthesized via recombinant DNA technology in our day. The activities of these substances in the treatment of virus infections are a matter of research (Biçer, 2008).

#### **6.3 Antifungal drugs**

#### **6.3.1 Amphotericin B liposome**

It destroys the cell membrane permeability. It is used in progressive and fatal infections as a result of toxicity (Apak, 1996; Dökmeci, 2001; Eroğlu, 2002).

*Uses:* Treatment of systemic fungal infections resistant to conventional amphotericin B therapy or in patients with renal or hepatic dysfunction (Young & Mangum, 2010).Dose: 5 to 7 mg/kg dose Q24 hours IV infusion by syringe pump over 2 hours (Young & Mangum, 2010).

It is administered by IV route every 2-6 hours in a 5% dextrose solution. It is started with 0.25 mg/kg/day and increased by 0.25 mg/kg/day in 1-2 days and can be advanced up to 1-1.5 mg/kg/day (Apak, 1996; Dökmeci, 2001; Eroğlu, 2002).

*Side Effects:* Anemia, thrombocytopenia, hypokalemia, nausea/vomiting, and fever/chills (Young & Mangum, 2010).
