**6.4.23 Hydroxyzine hydrochloride**

Uses: Sedative/hypnotic. Anesthesia induction. Treatment of refractory seizures.

Dose: IV: 0.05 to 0.15 mg/kg over at least 5 minutes. Repeat as required, usually Q2 to 4 hours. May also be given IM. Dosage requirements are decreased by incurrent use of narcotics.

Adverse Effects: Pediatric patients: desaturation 4.6%, apnea 2.8%, hypotension 2.7%, paradoxical reactions 2.0%, hiccough 1.2%, seizure like activity 1.1% and nystagmus 1.1%. The majority of airway-related events occurred in patients receiving other CNS depressing medications and in patients where midazolam was not used as a single sedating agent (Young & Mangum, 2010).
