**4.1 Brief summary of results**

In this study, per-treatment of patients with acute anterior STEMI undergoing primary coronary angioplasty prevented severe dysfunction of the coronary microcirculation as evidenced by absence of early systolic flow reversal in subjects treated with epitifibatide; however, less severe dysfunction of the microcirculation was not different between the groups since diastolic deceleration times by Doppler, and myocardial blush grades were similar. Moreover, diastolic maximal blood velocities early after PCI were higher in patients treated with eptifibatide but similar later on. Eptfibatide treatment was associated with a tendency of larger diastolic blood flow through the LAD but not later. All these changes with eptifibatide treatment did not affect left ventricular systolic function which was similar in both treatment groups, early after PCI and pre-discharge.
