**Meet the editor**

Dr. Amit Nagal is a Bioinformatics scientist in the area of rational drug design and Next- generation sequencing data analysis. He is currently working in Ocimum Biosolution, India and has several years of experience in this field. So far he had published several papers in peer reviewed journals and has presented on many international symposiums. Dr. Nagal has done his thesis

on computational and molecular aspects of lens regeneration under the influence of retinoid, explaining how retinoid and their derivatives interact with Retinoid X receptor (Rxr alpha) and in line with that he developed lens regeneration tools and a database. He also worked on development of Target and lead based modern lead designing pipeline where he used a novel QSAR ranking method with help of a support vector machine algorithm to classify scaffold and their biological activity. The main aim of this project is to develop a unique platform in the area of computer aided molecule design. Currently he is working on Next-generation sequencing data analysis and he is a member of ISCB and HUGO organization.

Contents

**Preface IX** 

Amit Nagal

**Part 3 Bachcet's Disease 25** 

Chapter 4 **Anti-Inflammatory Actions of the** 

**Part 1 Urinary Trypsin Inhibitor 1** 

Chapter 1 **Urinary Trypsin Inhibitor, an Alternative Therapeutic Option for Inflammatory Disorders 3**  Ken-ichiro Inoue and Hirohisa Takano

**Part 2 Design of hn-SPLA2 Inhibitors: A Structure Based** 

**Phospholipase A2 (hnps-PLA2) Inhibitors:** 

**A Structure Based Molecule Design Approach 17** 

Chapter 3 **Th17 Trafficking Cells in Behcet's Disease Skin Lesions 27**  Hamzaoui Kamel, Bouali Eya and Houman Habib

**Part 4 Activate Protein C Role in Inflammatory Disease 43** 

Véronique Freund-Michel, Bernard Muller and Nelly Frossard

Susan Costantini, Ankush Sharma and Giovanni Colonna

**Anticoagulant, Activated Protein C 45**  Christopher John Jackson and Meilang Xue

**Part 5 Role of TrkA Receptor in Inflammation 73** 

Chapter 5 **Expression and Role of the TrkA Receptor in Pulmonary Inflammatory Diseases 75** 

**Part 6 The Value of Cytokinome Profile 101** 

Chapter 6 **The Value of the Cytokinome Profile 103** 

**Molecule Design Approach 15** 

Chapter 2 **Design of Human Non-Pancreatic Secretary** 

### Contents

#### **Preface XI**

	- **Part 2 Design of hn-SPLA2 Inhibitors: A Structure Based Molecule Design Approach 15**

#### **Part 3 Bachcet's Disease 25**

	- **Part 4 Activate Protein C Role in Inflammatory Disease 43**
	- **Part 5 Role of TrkA Receptor in Inflammation 73**
	- **Part 6 The Value of Cytokinome Profile 101**

#### **Part 7 Pancreatic Cancer 129**

	- **Part 8 Role of Polyunsaturated Fatty Acids in Inflammatory Disease 157**
	- **Part 9 Noninvasive Inflammatory Biomarkers 179**
	- **Part 10 Role of AC0T7 201**
	- **Part 11 Inflammatory Bowel Disease 219**

### Preface

"Inflammatory Diseases – A Modern Perspective" represents an extended and thoroughly revised collection of papers on inflammation. This book explores a wide range of topics relevant to inflammation and inflammatory diseases while its main objective is to help in understanding the molecular mechanism and a concrete review of inflammation. One of the interesting things about this book is its diversity in topics which include pharmacology, medicine, rational drug design, microbiology and biochemistry. Each topic focuses on inflammation and its related disease thus giving a unique platform which integrates all the useful information regarding inflammation.

#### About the Contents

Chapter 1 contains an introduction to Urinary trypsin inhibitor (UTI), a serine protease inhibitor which is found to be a good therapeutic option for endotoxin-related inflammatory disorders such as DIC, acute lung injury in targeted mice model.

Chapter 2 concerns structure based molecule design approaches and comparative docking studies of various hnps-PLA2 indole inhibitor derivatives. In this study they proved that molecule 13h could be a novel anti-inflammatory drug.

Chapter 3 formally supports a model wherein Th1 andIL-17+ T cells mechanistically interact and collaboratively contribute to BD skin pathogenesis. This is found to be a beneficial for further study in Behcet's disease skin lesions

Chapter 4 contains a review of the most Activate Protein C role in inflammatory disease

Chapter 5 is devoted to the formal theory of role and expression TrkA receptor in the pulmonary hypertension. This chapter well explains the importance of TrkA receptor.

Chapter 6 concerns review of cytokines, their major role in chronic inflammatory diseases and cancers and it also elucidates challenge and significance of the cytokinome profile.

Chapter 7 examines Periodontal Inflammation as Risk Factor for Pancreatic Diseases. It also explores and investigates pancreatic tissue for the potential presence of periodontopathogenic microorganisms.

#### X Preface

Chapter 8 is entirely devoted to Polyunsaturated fatty acids. It well explains that they play critical roles in physiologic and pathophysiologic processes involving the immune system and have the ability to alter cellular responses as free fatty acids, most interest is on the properties of the array of metabolic products which they generate. These form a regulatory network which either down or up-regulates the inflammatory reaction.

Chapter 9 concerns the importance of asthma especially scientific knowledge which can help to address how and why this condition occurs and may contribute to a better understanding of the classification of each asthma patient.

Chapter 10 is discussion of the functional and structural characterization of AC0T7 in macrophages and their role in inflammation.

Chapter 11 contains interesting observations of dietary n-3 PUFA and n-3 PUFA-rich food such as salmon which plays crucial role to reduce inflammatory bowel disease.

> **Amit Nagal, PhD**  Bioinformatics Analyst Ocimum Biosolution, Hyderabad, India

X Preface

Chapter 8 is entirely devoted to Polyunsaturated fatty acids. It well explains that they play critical roles in physiologic and pathophysiologic processes involving the immune system and have the ability to alter cellular responses as free fatty acids, most interest is on the properties of the array of metabolic products which they generate. These form a regulatory network which either down or up-regulates the inflammatory reaction.

Chapter 9 concerns the importance of asthma especially scientific knowledge which can help to address how and why this condition occurs and may contribute to a better

Chapter 10 is discussion of the functional and structural characterization of AC0T7 in

Chapter 11 contains interesting observations of dietary n-3 PUFA and n-3 PUFA-rich food such as salmon which plays crucial role to reduce inflammatory bowel disease.

Bioinformatics Analyst Ocimum Biosolution, Hyderabad,

**Amit Nagal, PhD** 

India

understanding of the classification of each asthma patient.

macrophages and their role in inflammation.

**Part 1** 

**Urinary Trypsin Inhibitor** 
