**Acknowledgement**

This work was supported in part by Faculty Development Research Fund (FRDF) from the University of Auckland awarded to V. Shim and Federal Ministry of Education and Research (BMBF) grant awarded to J. Böhme. The authors would like to thank Mr. Sharif Malak for his work in orthogonal cutting of PU-foams.

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**Author details** 

V. Shim and I. Anderson

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**Chapter 10** 

© 2012 Butnaru et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2012 Butnaru et al., licensee InTech. This is a paper distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**Biocompatibility and Biological** 

**Performance of the Improved Polyurethane** 

Polyurethanes (PUs) are one of the most "pluripotent" synthetic polymer classes used in medical applications. Due to their structural versatility, they have been widely discussed as materials appropriate for biomedical applications (Abd El-Rehim & El-Amaouty, 2004; Guelcher et. al., 2007; Guelcher, 2008; Kavlock et. al, 2007; J.S. Lee et. al., 2001; Lelah & Cooper, 1987; Siepe et. al., 2007). Up to now, new PUs have been synthesized that possess good mechanical properties. Most of them are considered biocompatible on account of *in* 

However, it is well known that structural and mechanical adaptability of PUs is not always accompanied by cell and tissue biocompatibility. Therefore, numerous data in the literature are focused on biocompatibilization or functionalization of PUs (Yao, 2008; Sartori, 2008, Huang & Xu, 2010). Some promising methods for the improvement of biological response of PUs are conjugation, blending or coating with natural polymers. Thus, polysaccharides as chitosan, cellulose and their derivatives (Raschip, 2009; Zia, 2009; Zuo, 2009), proteins and glycoproteins as collagen, fibrin, fibronectin (R. Chen et. al., 2010; Sartori et. al., 2008), proteoglycans and glycosaminoglycans (Gong et. al., 2010) and other molecules (Hwang & Meyerhoff, 2008; Hsu et. al., 2004; Makala et. al., 2006; Song et. al., 2005; Verma & Marsden, 2005) are employed successfully for PUs modification. Owing its specific properties, hydroxypropylcellulose (HPC) is already used as binder, thickener, lubricating material (artificial tears) and emulsion stabilizer in pharmaceutical and food industry. Moreover, HPC may provide interactions through its hydroxyl radicals, being an excellent compound for copolymerization in scaffolds for tissue engineering and in drug delivery systems (Berthier et. al., 2011; D. Chen & Sun, 2000; Gutowska et. al., 2001; Raschip et. al., 2009;

**Membranes for Medical Applications** 

Cristina Daniela Dimitriu, Laura Knieling and Valeria Harabagiu

Maria Butnaru, Ovidiu Bredetean, Doina Macocinschi,

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/34653

*vitro* cytotoxicity evaluation.

**1. Introduction** 


**Chapter 10** 
