**2.2.1 Detection of N-terminal sequence with Edman degradation method**

The Edman degradation method used for sequencing can obtain a precise peptide sequence, therefore making it a major method for protein identification. Yet its sequencing speed is slow and expansive. With technical breakthroughs in microsequencing and speed, Edman degradation method will exert a major role in proteome researches. The C-terminal Maxam-Gilbert method, similar to Edman, has been studied for years and produced automated analyzers, but its reaction efficiency is low and usually requires more samples.
