**2.2.6 Algorithm {6} Molina et al.**

Three consecutive measurements. The first is below cut-off and the next two measurements are both over double the cut-off value (Molina et al., 1995).

This algorithm Molina et al. {6} is comparable with algorithm Chan et al. {4} - a confirmation of crossing cut-off with an extra sample - but at algorithm Molina et al.{6}, there is a doubling of the cut-off (to 190 U/L).

This very restrictive criterion results in 0% FP results – even also near cut-off. This algorithm has the lowest number of FP, i.e. 0%, in comparison to all the other algorithms. And, again, strict restrictions inhibit the ability to detect early tumour progression – algorithm Molina et al. {6} has the longest detection time shared with algorithm Söletormos et al.B {5} and algorithm Nicolini et al {7}.
