**4. Discussion**

118 Biomarker

Results (Comparisons between patients and HC; p-values)

Results

p-values)

Glutamate: ns

Lactate-tibialis: ns Pyruvate-tibialis: ns Glutamate-tibialis: ns Hypoxanthinetibialis: ns Urate-tibialis: ns Aspartate-tibialis: ns

(Comparisons between patients and HC;

PGE2:TE>HC;P< 0.001

Glutamate: JK>HC;

P=0.01 PGE2: ns

Lactate Lactate: CAT>HC; P=0.05

Table 8. Studies of tendons with chronic pain. The results of the different substances are

Comments (Compensated for RR (Y/N) or low flow rate\* (NA or Y/N)

Compensated for

Comments (Compensated for RR (Y/N) or low

Compensated for RR: N Low flow: Y

Compensated for RR: N Low flow: Y

Compensated for RR: N Low flow: Y

flow\* (NA or Y/N))

RR: N Low flow: Y

Substances investigated Flow rate

Lactate Pyruvate Glutamate Hypoxanthine

Urate Aspartate 0.3µl/min

\*Low flow rate associated with 100% relative recovery was defined as 0.3µl/min.

Table 7. Studies of mitochondrial myopathy. The results of the different substances are

Substances investigated

Glutamate PGE2

Glutamate PGE2

Study Condition

W

Study Condition

Axelson et al (Axelson et al., 2002)

Alfredson et al

Alfredson et al

Alfredson et al (Alfredson, 2005)

(Alfredson et al., 2001)

(Alfredson et al., 2000)

 Number of Subjects, % women(W) Muscles

Mitochondrial Myopathy (MM; n=4); 50% W HC (n=11), 36%

Tibialis anterior

 Number of Subjects, % women(W) Tendon

Tennis Elbow (TE; n=4), 25% W HC (n=4), 50%W

Extensor carpi radialis brevis tendon

Jumpers' knee (JK; n=5), 20%W HC (n=5), 20%W

Patellar tendon

HC (n=5), 0%W Achilles tendon

baseline data. Healthy controls are abbreviated as HC.

Chronic Achilles tendinosis (CAT; n=4), 0%W

\*Low flow was defined as 0.3µl/min.

baseline data. Healthy controls are abbreviated as HC.
