**2.1.3 Tumour biomarker increase**

The estimated values for the rate of increase (λ) in biomarkers after relapse in women with breast cancer are available (Söletormos et al., 2000a). The increase is assumed to be exponential (eλt) and the λ-values for the 5%, 50%, and 95% percentiles are 0.0132, 0.0346, and 0.0907, respectively (Söletormos et al., 2000a).
