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**8** 

*Spain* 

**Hydrodynamics Influence on** 

*Department of Chemical Engineering and Food Technology,* 

A. Montes, A. Tenorio, M. D. Gordillo, C. Pereyra and E. J. Martinez de la Ossa

*Faculty of Science, UCA* 

**Particles Formation Using SAS Process** 

Particle size and particle size distribution play an important role in many fields such cosmetic, food, textile, explosives, sensor, catalysis and pharmaceutics among others. Many properties of industrial powdered products can be adjusted by changing the particle size and particle size distribution of the powder. The conventional methods to produce microparticles have several drawbacks: wide size distribution, high thermal and mechanical stress, environmental pollution, large quantities of residual organic solvent and multistage

The application of supercritical fluids (SCF) as an alternative to the conventional precipitation processes has been an active field of research and innovation during the past two decades (Jung & Perrut, 2001; Martín& Cocero, 2008; Shariati &Peters, 2003).Through its impact on health care and prevention of diseases, the design of pharmaceutical preparations in nanoparticulate form has emerged as a new strategy for drug delivery. In this way, the technology of supercritical fluids allows developing micronized drugs and polymer-drug composites for controlled release applications; this also meets the pharmaceutical requirements for the absence of residual solvent, correct technological and biopharmaceutical properties and high quality (Benedetti et al., 1997; Elvassore et al., 2001; Falk& Randolph, 1998; Moneghini et al., 2001; Reverchon& Della Porta, 1999; Reverchon, 2002; Subramaniam et al., 1997; Yeo et al., 1993; Winters et al.,1996), as well as giving enhanced therapeutic action compared with traditional formulations (Giunchedi et al., 1998;

The revised literature demonstrates that there are two principal ways of micronizing and encapsulating drugs with polymers: using supercritical fluid as solvent, the RESS technique (Rapid Expansion of Supercritical Solutions); or using it as antisolvent, the SAS technique (Supercritical AntiSolvent); the choice of one or other depends on the high or low solubility,

Although the experimental parameters influences on the powder characteristic as particle size and morphologies is now qualitatively well known, the prediction of the powder characteristics is not feasible yet. This fact it is due to different physical phenomena involved in the SAS process. In most cases, the knowledge of the fluid phase equilibrium is

respectively, of the polymer and drug in the supercritical fluid.

**1. Introduction** 

processes are some of them.

Okada& Toguchi, 1995).

